Effects of Long-Acting Methylphenidate Formulations and Atomoxetine on Cardiac Functions in Children with Attention Deficit And Hyperactivity Disorder

Ajda Mutlu Mıhçıoğlu; Tayfun Kara

Makale detayları

Effects of Long-Acting Methylphenidate Formulations and Atomoxetine on Cardiac Functions in Children with Attention Deficit And Hyperactivity Disorder

Yazarlar:

Ajda Mutlu Mıhçıoğlu | Tayfun Kara

Yayıncı:

Kocaeli University

Ana Başlıklar:

Çocuk Sağlığı ve Hastalıkları

Dergi:

Acta Medica Nicomedia Vol.6 Issue 1, pp.98-106

Belge Tipi:

Makale

Yayın Tarihi:

2/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001284609

pISSN:

2717-8994

Anahtar kelimeler:

Özet:

 Objectives: Methylphenidate MPH and Atomoxetine ATX are most commonly prescribed for the treatment of Attention Deficit And Hyperactivity Disorder ADHD. Despite their widespread use, there are concerns about their cardiovascular safety. In this study, we aimed to investigate the effects of ADHD medications on cardiac functions. Methods: Forty-six children with ADHD disorder using osmotic-release oral system methylphenidate OROS-MPH, 46 using extended-release methylphenidate ER-MPH, and 46 using ATX for at least six months were included in the patient groups. 46 children with normal cardiac findings were included as the control group. All participants were evaluated using a sociodemographic information form, physical examination, 12-channel electrocardiography ECG, transthoracic 2D echocardiography, Doppler echocardiography, and tissue Doppler imaging TDI. Results: Statistically significant differences were observed in terms of A wave velocity p0,002, EA p0,001, and E septal p0,002 between the groups. Children using ATX had higher A wave velocity than OROS-MPH users and controls p0.001, p0.007, respectively and lower EA than OROS-MPH users and controls p0.001, for both. Children using ER-MPH and ATX had lower E septal values compared to the control group p0.001, p0.002, respectively. Heart rate is higher in ATX users than in the control group p0,002. Systolic blood pressure was lower in the ER-MPH and ATX group compared to the control group p0.001, for both. Conclusion: ATX medication exhibited impaired myocardial relaxation findings more than long acting-MPH medications. ER-MPH medication stated negative findings in diastolic cardiac functions more than OROS-MPH. As a result ADHD medications can produce negative effects on cardiac functions.

 Objectives: Methylphenidate MPH and Atomoxetine ATX are most commonly prescribed for the treatment of Attention Deficit And Hyperactivity Disorder ADHD. Despite their widespread use, there are concerns about their cardiovascular safety. In this study, we aimed to investigate the effects of ADHD medications on cardiac functions. Methods: Forty-six children with ADHD disorder using osmotic-release oral system methylphenidate OROS-MPH, 46 using extended-release methylphenidate ER-MPH, and 46 using ATX for at least six months were included in the patient groups. 46 children with normal cardiac findings were included as the control group. All participants were evaluated using a sociodemographic information form, physical examination, 12-channel electrocardiography ECG, transthoracic 2D echocardiography, Doppler echocardiography, and tissue Doppler imaging TDI. Results: Statistically significant differences were observed in terms of A wave velocity p0,002, EA p0,001, and E septal p0,002 between the groups. Children using ATX had higher A wave velocity than OROS-MPH users and controls p0.001, p0.007, respectively and lower EA than OROS-MPH users and controls p0.001, for both. Children using ER-MPH and ATX had lower E septal values compared to the control group p0.001, p0.002, respectively. Heart rate is higher in ATX users than in the control group p0,002. Systolic blood pressure was lower in the ER-MPH and ATX group compared to the control group p0.001, for both. Conclusion: ATX medication exhibited impaired myocardial relaxation findings more than long acting-MPH medications. ER-MPH medication stated negative findings in diastolic cardiac functions more than OROS-MPH. As a result ADHD medications can produce negative effects on cardiac functions.

 Objectives: Methylphenidate MPH and Atomoxetine ATX are most commonly prescribed for the treatment of Attention Deficit And Hyperactivity Disorder ADHD. Despite their widespread use, there are concerns about their cardiovascular safety. In this study, we aimed to investigate the effects of ADHD medications on cardiac functions. Methods: Forty-six children with ADHD disorder using osmotic-release oral system methylphenidate OROS-MPH, 46 using extended-release methylphenidate ER-MPH, and 46 using ATX for at least six months were included in the patient groups. 46 children with normal cardiac findings were included as the control group. All participants were evaluated using a sociodemographic information form, physical examination, 12-channel electrocardiography ECG, transthoracic 2D echocardiography, Doppler echocardiography, and tissue Doppler imaging TDI. Results: Statistically significant differences were observed in terms of A wave velocity p0,002, EA p0,001, and E septal p0,002 between the groups. Children using ATX had higher A wave velocity than OROS-MPH users and controls p0.001, p0.007, respectively and lower EA than OROS-MPH users and controls p0.001, for both. Children using ER-MPH and ATX had lower E septal values compared to the control group p0.001, p0.002, respectively. Heart rate is higher in ATX users than in the control group p0,002. Systolic blood pressure was lower in the ER-MPH and ATX group compared to the control group p0.001, for both. Conclusion: ATX medication exhibited impaired myocardial relaxation findings more than long acting-MPH medications. ER-MPH medication stated negative findings in diastolic cardiac functions more than OROS-MPH. As a result ADHD medications can produce negative effects on cardiac functions.

 Amaç: Dikkat Eksikliği ve Hiperaktivite Bozukluğunun DEHB tedavisinde metilfenidat MPH ve atomoksetin ATX en yaygın olarak reçete edilen ilaçlardır. Yaygın kullanılmalarına rağmen, kardiyovasküler güvenilirlikleri hakkında endişeler vardır. Bu çalışmada DEHB ilaçlarının kardiyak fonksiyonlar üzerine etkilerini araştırmayı amaçladık. Yöntem: Hasta gruplarına 46 ozmotik-salınımlı oral sistem metilfenidat OROS-MPH kullanan hasta, 46 geç-salınımlı metilfenidat ER-MPH kullanan hasta ve en az altı aydır ATX kullanan 46 DEHB tanılı çocuk dahil edildi. Normal kardiyak bulguları olan 46 çocuk kontrol grubu olarak alındı. Tüm katılımcılar sosyodemografik bilgi formu, fizik muayene, 12 kanallı elektrokardiyografi EKG, transtorasik 2D ekokardiyografi, Doppler ekokardiyografi ve doku Doppler görüntüleme TDI kullanılarak değerlendirildi. Bulgular: Gruplar arasında A dalga hızı, EA ve E septal parametrelerinde istatistiksel olarak anlamlı fark izlendi p0,002, p0,001, p0,002, sırasıyla. ATX kullanan çocuklarda, OROS-MPH kullananlara ve kontrollere göre daha yüksek A dalga hızı p0,001, p0,007, sırasıyla ve OROS-MPH kullananlara ve kontrollere göre daha düşük EA p0,001, her ikisi için saptandı. ER-MPH ve ATX kullanan çocukların E septal değerleri kontrol grubuna göre daha düşüktü p0,001, p0,002, sırasıyla. Kalp hızı ATX kullananlarda kontrol grubuna göre daha yüksekti p0,002. ER-MPH ve ATX grubunda sistolik kan basıncı kontrol grubuna göre daha düşüktü p 0,001. Sonuç: ATX tedavisi, uzun etkili MPH ilaçlarından daha fazla miyokardiyal relaksasyonda bozulmaya sebep olmuştur. ER-MPH tedavisi, kardiyak diyastolik fonksiyonlar üzerinde OROS-MPHye göre daha fazla negatif etki yaratmıştır. Sonuç olarak, DEHB ilaçları kardiyak fonksiyonlar üzerinde olumsuz etkiler yaratabilir.

Makale detayları

Effects of Long-Acting Methylphenidate Formulations and Atomoxetine on Cardiac Functions in Children with Attention Deficit And Hyperactivity Disorder

Yazarlar:

Ajda Mutlu Mıhçıoğlu | Tayfun Kara

Yayıncı:

Kocaeli University

Ana Başlıklar:

Çocuk Sağlığı ve Hastalıkları

Dergi:

Acta Medica Nicomedia Vol.6 Issue 1, pp.98-106

Belge Tipi:

Makale

Yayın Tarihi:

2/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001284609

pISSN:

2717-8994

methyphenidate

atomoxetine

tissue Doppler imaging

attention deficit and hyperactivity disorder

metilfenidat

atomoksetin

doku Doppler görüntüleme

dikkat eksikliği ve hiperaktivite bozukluğu

Sayı

Makale detayları

Yazarlar: Ajda Mutlu Mıhçıoğlu | Tayfun Kara

Yayıncı: Kocaeli University

Ana Başlıklar: Çocuk Sağlığı ve Hastalıkları

Dergi: Acta Medica Nicomedia Vol.6 Issue 1, pp.98-106

Belge Tipi: Makale

Yayın Tarihi: 2/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001284609

pISSN: 2717-8994

Sayı

Yazarlar:

Ajda Mutlu Mıhçıoğlu | Tayfun Kara

Yayıncı:

Kocaeli University

Ana Başlıklar:

Çocuk Sağlığı ve Hastalıkları

Dergi:

Acta Medica Nicomedia Vol.6 Issue 1, pp.98-106

Belge Tipi:

Makale

Yayın Tarihi:

2/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001284609

pISSN:

2717-8994