Optimization of Parameters for The Design and Evaluation of Fenofibrate Loaded Floating Microspheres by Taguchi Method

Mahesh Agasa Ramu

Makale detayları

Optimization of Parameters for The Design and Evaluation of Fenofibrate Loaded Floating Microspheres by Taguchi Method

Yazarlar:

Mahesh Agasa Ramu

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 1, pp.130-144

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001345947

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Fenofibrate is an anti-hyperlipidemic agent with poor water solubility and poor bioavailability of 30. The goal of this study was to develop and optimise floating microspheres of Fenofibrate utilising an emulsion solvent diffusion method in order to improve absorption and oral bioavailability of the medicine for a better approach in treating hyperlipidemic conditions using ethyl cellulose as a polymer. At the preliminary stage four formulations were prepared by changing the polymer ratio and keeping the stirring speed, stirring time and solvent composition constant. Based on the results obtained batch 2 was considered as an ideal batch. The data from this batch was used at the middle level of a Taguchi orthogonal array design to optimise the formulation, and the effect of independent variables such as A Polymer concentration, B Stirring speed, C Stirring time, and D Ethanol concentration on dependent variables such as particle size, percentage yield, drug loading, buoyancy, and drug release was investigated. All the microspheres showed good buoyancy for 24 h in simulated gastric fluid and controlled release of drug for 12 hours. The optimized formulation was spherical in shape as confirmed by photographs from scanning electron microscopy. The in vitro release data were fitted into various kinetic models and the possible release mechanism was found to follow Korsmeyer-Peppas model. The results suggest that Fenofibrate floating microspheres provides modified drug release for treating hyperlipidemia and can be used successfully for development of sustain release formulation.

 Fenofibrate is an anti-hyperlipidemic agent with poor water solubility and poor bioavailability of 30. The goal of this study was to develop and optimise floating microspheres of Fenofibrate utilising an emulsion solvent diffusion method in order to improve absorption and oral bioavailability of the medicine for a better approach in treating hyperlipidemic conditions using ethyl cellulose as a polymer. At the preliminary stage four formulations were prepared by changing the polymer ratio and keeping the stirring speed, stirring time and solvent composition constant. Based on the results obtained batch 2 was considered as an ideal batch. The data from this batch was used at the middle level of a Taguchi orthogonal array design to optimise the formulation, and the effect of independent variables such as A Polymer concentration, B Stirring speed, C Stirring time, and D Ethanol concentration on dependent variables such as particle size, percentage yield, drug loading, buoyancy, and drug release was investigated. All the microspheres showed good buoyancy for 24 h in simulated gastric fluid and controlled release of drug for 12 hours. The optimized formulation was spherical in shape as confirmed by photographs from scanning electron microscopy. The in vitro release data were fitted into various kinetic models and the possible release mechanism was found to follow Korsmeyer-Peppas model. The results suggest that Fenofibrate floating microspheres provides modified drug release for treating hyperlipidemia and can be used successfully for development of sustain release formulation.

 Fenofibrate is an anti-hyperlipidemic agent with poor water solubility and poor bioavailability of 30. The goal of this study was to develop and optimise floating microspheres of Fenofibrate utilising an emulsion solvent diffusion method in order to improve absorption and oral bioavailability of the medicine for a better approach in treating hyperlipidemic conditions using ethyl cellulose as a polymer. At the preliminary stage four formulations were prepared by changing the polymer ratio and keeping the stirring speed, stirring time and solvent composition constant. Based on the results obtained batch 2 was considered as an ideal batch. The data from this batch was used at the middle level of a Taguchi orthogonal array design to optimise the formulation, and the effect of independent variables such as A Polymer concentration, B Stirring speed, C Stirring time, and D Ethanol concentration on dependent variables such as particle size, percentage yield, drug loading, buoyancy, and drug release was investigated. All the microspheres showed good buoyancy for 24 h in simulated gastric fluid and controlled release of drug for 12 hours. The optimized formulation was spherical in shape as confirmed by photographs from scanning electron microscopy. The in vitro release data were fitted into various kinetic models and the possible release mechanism was found to follow Korsmeyer-Peppas model. The results suggest that Fenofibrate floating microspheres provides modified drug release for treating hyperlipidemia and can be used successfully for development of sustain release formulation.

 Fenofibrate is an anti-hyperlipidemic agent with poor water solubility and poor bioavailability of 30. The goal of this study was to develop and optimise floating microspheres of Fenofibrate utilising an emulsion solvent diffusion method in order to improve absorption and oral bioavailability of the medicine for a better approach in treating hyperlipidemic conditions using ethyl cellulose as a polymer. At the preliminary stage four formulations were prepared by changing the polymer ratio and keeping the stirring speed, stirring time and solvent composition constant. Based on the results obtained batch 2 was considered as an ideal batch. The data from this batch was used at the middle level of a Taguchi orthogonal array design to optimise the formulation, and the effect of independent variables such as A Polymer concentration, B Stirring speed, C Stirring time, and D Ethanol concentration on dependent variables such as particle size, percentage yield, drug loading, buoyancy, and drug release was investigated. All the microspheres showed good buoyancy for 24 h in simulated gastric fluid and controlled release of drug for 12 hours. The optimized formulation was spherical in shape as confirmed by photographs from scanning electron microscopy. The in vitro release data were fitted into various kinetic models and the possible release mechanism was found to follow Korsmeyer-Peppas model. The results suggest that Fenofibrate floating microspheres provides modified drug release for treating hyperlipidemia and can be used successfully for development of sustain release formulation.

Makale detayları

Optimization of Parameters for The Design and Evaluation of Fenofibrate Loaded Floating Microspheres by Taguchi Method

Yazarlar:

Mahesh Agasa Ramu

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 1, pp.130-144

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001345947

pISSN:

2630-6344

Fenofibrate

Ethyl Cellulose

Eudragit RL100

Anti-hyperlipidemic

Taguchi design

Sayı

Makale detayları

Optimization of Parameters for The Design and Evaluation of Fenofibrate Loaded Floating Microspheres by Taguchi Method

Yazarlar: Mahesh Agasa Ramu

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.27 Issue 1, pp.130-144

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001345947

pISSN: 2630-6344

Fenofibrate

Ethyl Cellulose

Eudragit RL100

Anti-hyperlipidemic

Taguchi design

Sayı

Yazarlar:

Mahesh Agasa Ramu

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 1, pp.130-144

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001345947

pISSN:

2630-6344