Impact of glycemic status on left ventricular systolic function in patients with acute coronary syndrome

Alaaeldin Abdelhady AMİN; Waleed Abdelsalam AMMAR; Azza Abdelmoniem FARRAG

doi:https://doi.org/10.5455/umj.20150924034203

Makale detayları

Impact of glycemic status on left ventricular systolic function in patients with acute coronary syndrome

Yazarlar:

Alaaeldin Abdelhady AMİN | Waleed Abdelsalam AMMAR | Azza Abdelmoniem FARRAG

Yayıncı:

Kemal Türker ULUTAŞ

Dergi:

The Ulutas Medical Journal 2015 Vol.1 Issue 3, pp.58-63

Belge Tipi:

Makale

Yayın Tarihi:

6/2015

Belge Dili:

İngilizce

Document ID (Org No.):

2000802985

Sıklık:

Üç Aylık

eISSN:

2149-388X

pISSN:

2149-0430

DOI:

https://doi.org/10.5455/umj.20150924034203

Özet:

 

Background: Diabetes mellitus  DM  and left ventricular systolic dysfunction  LVSD  commonly coexist; increasing morbidity and mortality among patients. The aim of this study is to detect the correlation between the glycemic status of patients presenting by acute coronary syndrome  ACS  and left ventricular global and regional systolic function.    Method: The study included 510 patients presenting by ACS and referred for coronary angiography. In addition to routine laboratory tests, Glycated hemoglobin  HbA1C  level, as a marker of chronic glycemic status, was measured. Every patient was subjected to transthoracic echocardiographic study with accurate evaluation of left ventricular systolic function by both m-mode and biplane Simpson's method, in addition to calculation of regional wall motion score index  RWMSI . The whole study population was divided into two groups; diabetic and non-diabetic based on cutoff point of HbA1C value 6.5%. The non-diabetic group was subdivided into two groups; high risk and low risk based on cutoff point of HbA1C value 5.7%   Results: Sixty four percent of the studied population had DM. The mean HbA1C level was 7.6 ± 2.2%. The mean left ventricular ejection fraction  LVEF  was 54 ± 11 and mean RWMSI was 1.3 ± 0.3. There was significant negative correlation between the HbA1C level and the LVEF  r = -0.101, p < 0.022 . There was significant positive correlation between HbA1C level and RWMSI  r = 0.109, p < 0.014 . The non-diabetic high risk group had lower LVEF and higher RWMSI than the low risk group  p < 0.041 and p < 0.002 respectively .     Conclusion: Chronic hyperglycemia in patients with uncontrolled DM may be a risk factor for developing LVSD in patients presenting by ACS. Glycated hemoglobin level may predict LVSD in patients with ACS. Non-diabetic patients who are at higher risk of developing DM have higher incidence of LVSD.

Makale detayları

Impact of glycemic status on left ventricular systolic function in patients with acute coronary syndrome

Yazarlar: Alaaeldin Abdelhady AMİN | Waleed Abdelsalam AMMAR | Azza Abdelmoniem FARRAG

Yayıncı: Kemal Türker ULUTAŞ

Dergi: The Ulutas Medical Journal 2015 Vol.1 Issue 3, pp.58-63

Belge Tipi: Makale

Yayın Tarihi: 6/2015

Belge Dili: İngilizce

Document ID (Org No.): 2000802985

Sıklık: Üç Aylık

eISSN: 2149-388X

pISSN: 2149-0430

DOI: https://doi.org/10.5455/umj.20150924034203

Sayı

Yazarlar:

Alaaeldin Abdelhady AMİN | Waleed Abdelsalam AMMAR | Azza Abdelmoniem FARRAG

Yayıncı:

Kemal Türker ULUTAŞ

Dergi:

The Ulutas Medical Journal 2015 Vol.1 Issue 3, pp.58-63

Belge Tipi:

Makale

Yayın Tarihi:

6/2015

Belge Dili:

İngilizce

Document ID (Org No.):

2000802985

Sıklık:

Üç Aylık

eISSN:

2149-388X

pISSN:

2149-0430

DOI:

https://doi.org/10.5455/umj.20150924034203