RESULTS OF ORAL STEROID TREATMENT IN PATIENTS DIAGNOSED WITH IDIOPATHIC GRANULOMATOUS MASTITIS

Zehra Unal Ozdemir

Makale detayları

RESULTS OF ORAL STEROID TREATMENT IN PATIENTS DIAGNOSED WITH IDIOPATHIC GRANULOMATOUS MASTITIS

Yazarlar:

Zehra Unal Ozdemir

Yayıncı:

Izmir Katip Celebi University

Ana Başlıklar:

Hastalık Denetimi

Dergi:

Güncel Tıbbi Araştırmaları Dergisi Vol.3 Issue 3, pp.17-24

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001308443

pISSN:

2791-7061

Anahtar kelimeler:

Özet:

 Introduction: Idiopathic granulomatous mastitis IGM is a benign, chronic disease characterized by granulomatous inflammation in the breast tissue. There is still no standard treatment model for the disease. Treatment methods range from medical treatments to wide excisions. This study aimed to retrospectively analyze high-dose steroid use and its results in patients diagnosed with IGM. Materials and methods: In this retrospective study, 48 patients diagnosed with granulomatous mastitis were evaluated, and it was determined that 46 of these patients were diagnosed with IGM. Histopathological diagnosis was made by core biopsy. The patients age, gender, pathological diagnosis, culture results, presence of abscess, treatment dose, treatment duration, treatment responses, and recurrence were evaluated. Results: 48 patients diagnosed with granulomatous mastitis were evaluated. Two of these patients were excluded from the study because infectious agents were detected. 46 patients were included in the study. All patients were women. The average age of the patients was 36.32 years and the follow-up period was 28.52 months. The average PPD test results of the patients was found to be 5.58 mm. Patients were started on 0.8 mgkgday methylprednisolone tablets. After 3 weeks, the treatment was reduced by 0.1 mgkgday per week and completed after 10 weeks. Relapse was observed in 3 patients 6.52. No surgical procedure was performed on the patients. Abscess formation was observed in 9 patients while receiving steroid treatment. Samples were taken from these patients by aspiration and sent for culture. Coagulase - staphylococcus grew in 3 patients 6.52. Conclusion: It was concluded that high-dose steroid treatment is effective in IGM cases, and good results can be achieved with low recurrence rates and minimal deformity without the need for surgical intervention.

 Introduction: Idiopathic granulomatous mastitis IGM is a benign, chronic disease characterized by granulomatous inflammation in the breast tissue. There is still no standard treatment model for the disease. Treatment methods range from medical treatments to wide excisions. This study aimed to retrospectively analyze high-dose steroid use and its results in patients diagnosed with IGM. Materials and methods: In this retrospective study, 48 patients diagnosed with granulomatous mastitis were evaluated, and it was determined that 46 of these patients were diagnosed with IGM. Histopathological diagnosis was made by core biopsy. The patients age, gender, pathological diagnosis, culture results, presence of abscess, treatment dose, treatment duration, treatment responses, and recurrence were evaluated. Results: 48 patients diagnosed with granulomatous mastitis were evaluated. Two of these patients were excluded from the study because infectious agents were detected. 46 patients were included in the study. All patients were women. The average age of the patients was 36.32 years and the follow-up period was 28.52 months. The average PPD test results of the patients was found to be 5.58 mm. Patients were started on 0.8 mgkgday methylprednisolone tablets. After 3 weeks, the treatment was reduced by 0.1 mgkgday per week and completed after 10 weeks. Relapse was observed in 3 patients 6.52. No surgical procedure was performed on the patients. Abscess formation was observed in 9 patients while receiving steroid treatment. Samples were taken from these patients by aspiration and sent for culture. Coagulase - staphylococcus grew in 3 patients 6.52. Conclusion: It was concluded that high-dose steroid treatment is effective in IGM cases, and good results can be achieved with low recurrence rates and minimal deformity without the need for surgical intervention.

 Introduction: Idiopathic granulomatous mastitis IGM is a benign, chronic disease characterized by granulomatous inflammation in the breast tissue. There is still no standard treatment model for the disease. Treatment methods range from medical treatments to wide excisions. This study aimed to retrospectively analyze high-dose steroid use and its results in patients diagnosed with IGM. Materials and methods: In this retrospective study, 48 patients diagnosed with granulomatous mastitis were evaluated, and it was determined that 46 of these patients were diagnosed with IGM. Histopathological diagnosis was made by core biopsy. The patients age, gender, pathological diagnosis, culture results, presence of abscess, treatment dose, treatment duration, treatment responses, and recurrence were evaluated. Results: 48 patients diagnosed with granulomatous mastitis were evaluated. Two of these patients were excluded from the study because infectious agents were detected. 46 patients were included in the study. All patients were women. The average age of the patients was 36.32 years and the follow-up period was 28.52 months. The average PPD test results of the patients was found to be 5.58 mm. Patients were started on 0.8 mgkgday methylprednisolone tablets. After 3 weeks, the treatment was reduced by 0.1 mgkgday per week and completed after 10 weeks. Relapse was observed in 3 patients 6.52. No surgical procedure was performed on the patients. Abscess formation was observed in 9 patients while receiving steroid treatment. Samples were taken from these patients by aspiration and sent for culture. Coagulase - staphylococcus grew in 3 patients 6.52. Conclusion: It was concluded that high-dose steroid treatment is effective in IGM cases, and good results can be achieved with low recurrence rates and minimal deformity without the need for surgical intervention.

 Giriş: İdiopatik granülomatöz IGM mastit meme dokusunda granülomatöz bir inflamasyon ile karakterize benign, kronik bir hastalıktır. Hastalığın halen standart bir tedavi modeli bulunmamaktadır. Medikal tedavilerden geniş eksizyonlara kadar uzanan tedavi yöntemlerine rastlanılmaktadır. Bu çalışmada IGM tanılı hastalarda yüksek doz steroid kullanımı ve sonuçlarının retrospektif analizi amaçlanmıştır. Gereç ve yöntem: Bu retrospektif çalışmada 48 granülomatöz mastit tanılı hasta değerlendirildi, bu hastaların 46 tanesinin IGM tanısı aldığı belirlendi. Hastalara histopatolojik tanı core biyopsi ile konuldu. Hastaların yaşı, cinsiyeti, patolojik tanıları, kültür sonuçları, abse varlığı, tedavi dozu, tedavi süresi, tedavi cevapları ve nüks durumları değerlendirildi. Bulgular: Granülomatöz mastit tanısı alan 48 hasta değerlendirildi. Bu hastalardan ikisisinde enfeksiyon ajanları tespit edildiği için çalışma dışı bırakıldı. 46 hasta çalışmaya dahil edildi. Hastaların tamamı kadın idi. Hastaların yaş ortalaması 36,32 yıl, takip süresi 28,52 ay olarak bulundu. Hastaların PPD test sonuçlarının ortalaması 5,58 mm olarak bulundu. Hastalara 0,8 mgkggün metilprednizolon tablet başlandı. 3 hafta sonra haftada 0,1 mgkggün azaltılarak 10 hafta sonra tedavi tamamlandı. 3 hastada 6,52 nüks görüldü. Hastalara herhangi bir cerrahi işlem yapılmadı. Steroid tedavisi alırken 9 hastada apse formasyonu görüldü. Bu hastalardan aspirasyon ile örnek alınıp kültüre gönderildi. 3 hastada 6,52 koagülaz - stafilokok üredi. Sonuç: IGM olgularında yüksek doz steroid tedavisinin etkin, cerrahi müdahaleye gerek kalmadan düşük nüks oranları ve minimal deformite ile iyi sonuçlar ortaya koyabileceği sonucuna varılmıştır.

Makale detayları

RESULTS OF ORAL STEROID TREATMENT IN PATIENTS DIAGNOSED WITH IDIOPATHIC GRANULOMATOUS MASTITIS

Yazarlar:

Zehra Unal Ozdemir

Yayıncı:

Izmir Katip Celebi University

Ana Başlıklar:

Hastalık Denetimi

Dergi:

Güncel Tıbbi Araştırmaları Dergisi Vol.3 Issue 3, pp.17-24

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001308443

pISSN:

2791-7061

Idiopathic granulomatous mastitis

steroid

treatment

recurrenceİdiopatik granülomatöz mastit

steroid

tedavi

nüks

Sayı

Makale detayları

Yazarlar: Zehra Unal Ozdemir

Yayıncı: Izmir Katip Celebi University

Ana Başlıklar: Hastalık Denetimi

Dergi: Güncel Tıbbi Araştırmaları Dergisi Vol.3 Issue 3, pp.17-24

Belge Tipi: Makale

Yayın Tarihi: 12/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001308443

pISSN: 2791-7061

Sayı

Yazarlar:

Zehra Unal Ozdemir

Yayıncı:

Izmir Katip Celebi University

Ana Başlıklar:

Hastalık Denetimi

Dergi:

Güncel Tıbbi Araştırmaları Dergisi Vol.3 Issue 3, pp.17-24

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001308443

pISSN:

2791-7061