Evaluation of Retinal Layers by Optical Coherence Tomography in Patients with Acromegaly

Berna Evranos Öğmen

Makale detayları

Evaluation of Retinal Layers by Optical Coherence Tomography in Patients with Acromegaly

Yazarlar:

Berna Evranos Öğmen

Yayıncı:

Ankara University

Ana Başlıklar:

Ophthalmology | Endocrinology

Dergi:

Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.78 Issue 1, pp.8-12

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001349817

pISSN:

0365-8104

Anahtar kelimeler:

Özet:

 Objectives: Acromegaly, a rare endocrine disorder caused primarily by growth hormone GH secreting pituitary adenomas, leads to elevated levels of growth GH and insulin-like growth factor 1 IGF-1, resulting in systemic complications and ocular manifestations. These include increased corneal thickness, elevated intraocular pressure, retinal changes, and visual field defects. Spectral-domain optical coherence tomography SDOCT enables high-resolution, non-invasive assessment of individual retinal layers. This technique provides a thickness map of the following seven different retinal layers via automatic segmentation: retinal nerve fibre layer RNFL, ganglion cell layer GCL, inner plexiform layer IPL, inner nuclear layer INL, outer plexiform layer OPL, outer nuclear layer ONL, retinal pigment epithelium RPE. This study employed SD-OCT to evaluate the thickness of seven distinct retinal layers in patients with acromegaly, addressing a gap in the current literature. Materials and Methods: This cross-sectional comparative study included patients with acromegaly and age- and gender-matched healthy controls. Data collected included demographics, treatment modalities, disease activity status remission vs. non-remission, and IGF-1 levels. A single-blinded ophthalmologist performed OCT. The thickness of seven distinct retinal layers was compared between acromegaly patients and controls. Results: The study included 23 acromegaly patients and 18 healthy controls, with 46 and 36 eyes evaluated, respectively. The acromegaly group exhibited significantly reduced median thicknesses in the RNFL, GCL, IPL, and RPE layers compared to controls p0.05, while INL, OPL, and ONL showed no differences. Subgroup analysis revealed that INL thickness was significantly greater in non-remission patients than in those in remission p0.022. Conclusion: Retinal layer thinning, particularly in the RNFL, GCL, IPL, and RPE, was observed in acromegaly patients compared to healthy controls. Interestingly, patients with active disease had thicker retinal layers than those in remission, suggesting a role for IGF-1 in these changes. As the first comprehensive evaluation of all seven retinal layers in acromegaly, this study highlights the need for further research to clarify these findings and the impact of IGF-1 on retinal structure.

 Objectives: Acromegaly, a rare endocrine disorder caused primarily by growth hormone GH secreting pituitary adenomas, leads to elevated levels of growth GH and insulin-like growth factor 1 IGF-1, resulting in systemic complications and ocular manifestations. These include increased corneal thickness, elevated intraocular pressure, retinal changes, and visual field defects. Spectral-domain optical coherence tomography SDOCT enables high-resolution, non-invasive assessment of individual retinal layers. This technique provides a thickness map of the following seven different retinal layers via automatic segmentation: retinal nerve fibre layer RNFL, ganglion cell layer GCL, inner plexiform layer IPL, inner nuclear layer INL, outer plexiform layer OPL, outer nuclear layer ONL, retinal pigment epithelium RPE. This study employed SD-OCT to evaluate the thickness of seven distinct retinal layers in patients with acromegaly, addressing a gap in the current literature. Materials and Methods: This cross-sectional comparative study included patients with acromegaly and age- and gender-matched healthy controls. Data collected included demographics, treatment modalities, disease activity status remission vs. non-remission, and IGF-1 levels. A single-blinded ophthalmologist performed OCT. The thickness of seven distinct retinal layers was compared between acromegaly patients and controls. Results: The study included 23 acromegaly patients and 18 healthy controls, with 46 and 36 eyes evaluated, respectively. The acromegaly group exhibited significantly reduced median thicknesses in the RNFL, GCL, IPL, and RPE layers compared to controls p0.05, while INL, OPL, and ONL showed no differences. Subgroup analysis revealed that INL thickness was significantly greater in non-remission patients than in those in remission p0.022. Conclusion: Retinal layer thinning, particularly in the RNFL, GCL, IPL, and RPE, was observed in acromegaly patients compared to healthy controls. Interestingly, patients with active disease had thicker retinal layers than those in remission, suggesting a role for IGF-1 in these changes. As the first comprehensive evaluation of all seven retinal layers in acromegaly, this study highlights the need for further research to clarify these findings and the impact of IGF-1 on retinal structure.

 Objectives: Acromegaly, a rare endocrine disorder caused primarily by growth hormone GH secreting pituitary adenomas, leads to elevated levels of growth GH and insulin-like growth factor 1 IGF-1, resulting in systemic complications and ocular manifestations. These include increased corneal thickness, elevated intraocular pressure, retinal changes, and visual field defects. Spectral-domain optical coherence tomography SDOCT enables high-resolution, non-invasive assessment of individual retinal layers. This technique provides a thickness map of the following seven different retinal layers via automatic segmentation: retinal nerve fibre layer RNFL, ganglion cell layer GCL, inner plexiform layer IPL, inner nuclear layer INL, outer plexiform layer OPL, outer nuclear layer ONL, retinal pigment epithelium RPE. This study employed SD-OCT to evaluate the thickness of seven distinct retinal layers in patients with acromegaly, addressing a gap in the current literature. Materials and Methods: This cross-sectional comparative study included patients with acromegaly and age- and gender-matched healthy controls. Data collected included demographics, treatment modalities, disease activity status remission vs. non-remission, and IGF-1 levels. A single-blinded ophthalmologist performed OCT. The thickness of seven distinct retinal layers was compared between acromegaly patients and controls. Results: The study included 23 acromegaly patients and 18 healthy controls, with 46 and 36 eyes evaluated, respectively. The acromegaly group exhibited significantly reduced median thicknesses in the RNFL, GCL, IPL, and RPE layers compared to controls p0.05, while INL, OPL, and ONL showed no differences. Subgroup analysis revealed that INL thickness was significantly greater in non-remission patients than in those in remission p0.022. Conclusion: Retinal layer thinning, particularly in the RNFL, GCL, IPL, and RPE, was observed in acromegaly patients compared to healthy controls. Interestingly, patients with active disease had thicker retinal layers than those in remission, suggesting a role for IGF-1 in these changes. As the first comprehensive evaluation of all seven retinal layers in acromegaly, this study highlights the need for further research to clarify these findings and the impact of IGF-1 on retinal structure.

 Amaç: Akromegali, öncelikli olarak büyüme hormonu BH salgılayan hipofiz adenomu kaynaklı nadir bir endokrin hastalıktır ve BH ile insülin benzeri büyüme faktörü 1 IGF-1 seviyelerinin yükselmesine bağlı olarak sistemik komplikasyonlara ve oküler bulgulara yol açar. Bu bulgular arasında kornea kalınlığında artış, intraoküler basınç artışı, retinal değişiklikler ve görme alanı defektleri yer alır. Spektral-domain optik koherens tomografi SD-OCT, retina tabakalarının yüksek çözünürlüklü, non-invaziv değerlendirmesine olanak tanır. Bu teknikle, otomatik segmentasyon aracılığıyla yedi farklı retina tabakasının kalınlık ölçümü yapılabilir: retinal sinir lifi tabakası RNFL, ganglion hücre tabakası GCL, iç pleksiform tabaka IPL, iç nükleer tabaka INL, dış pleksiform tabaka OPL, dış nükleer tabaka ONL ve retinal pigment epiteli RPE. Bu çalışmada, akromegali hastalarında literatürdeki bir boşluğu doldurmak amacıyla, SD-OCT kullanarak, yedi farklı retinal tabakanın kalınlığını değerlendirmek amaçlandı. Gereç ve Yöntem: Bu kesitsel karşılaştırmalı çalışmaya, akromegali hastaları ile yaş ve cinsiyet açısından eşleştirilmiş sağlıklı kontrol bireyler dahil edilmiştir. Demografik özellikler, tedavi yöntemleri, hastalık aktivite durumu remisyonda veya değil ve IGF-1 seviyeleri kaydedildi. Tüm OCT ölçümleri, tek bir oftalmolog tarafından yapılmıştır. Akromegali hastaları ile kontrol grubu arasında yedi farklı retinal katmanın kalınlıkları karşılaştırılmıştır. Bulgular: Çalışmaya 23 akromegali hastası ve 18 sağlıklı kontrol dahil edilmiş; sırasıyla 46 ve 36 göz değerlendirilmiştir. Akromegali grubunda RNFL, GCL, IPL ve RPE katmanlarının medyan kalınlıkları kontrol grubuna kıyasla anlamlı olarak düşük bulunmuştur p0,05. INL, OPL ve ONL arasında fark gözlenmemiştir. Akromegali hastaları, remisyonda veya remisyonsuz olarak 2 gruba ayrıldığında, INL kalınlığı, remisyonsuz hastalarda anlamlı derecede daha yüksek bulunmuştur p0,022. Sonuç: Akromegali hastalarında RNFL, GCL, IPL ve RPE katmanlarının kontrol grubuna göre inceldiği, ancak aktif hastalık grubunda bu katmanların remisyondaki hastalara kıyasla daha kalın olduğu gözlenmiştir. Bu durum, IGF-1in retinal değişikliklerdeki rolüne işaret etmektedir. Akromegali hastalarında retinal tabakaların ayrıntılı olarak değerlendirildiği ilk çalışma olan bu araştırma ile IGF-1in retinal yapı üzerindeki etkisini açıklığa kavuşturmak için ek geniş kapsamlı araştırmalara ihtiyaç vardır.

Makale detayları

Evaluation of Retinal Layers by Optical Coherence Tomography in Patients with Acromegaly

Yazarlar:

Berna Evranos Öğmen

Yayıncı:

Ankara University

Ana Başlıklar:

Ophthalmology | Endocrinology

Dergi:

Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.78 Issue 1, pp.8-12

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001349817

pISSN:

0365-8104

Acromegaly

optical coherence tomography

retinal layers

retinal nerve fiber layer

ganglion cell layerAkromegali

optik koherens tomografi

retinal tabakalar

retinal sinir lif tabakası

gangliyon hücre tabakası

Sayı

Makale detayları

Yazarlar: Berna Evranos Öğmen

Yayıncı: Ankara University

Ana Başlıklar: Ophthalmology | Endocrinology

Dergi: Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.78 Issue 1, pp.8-12

Belge Tipi: Makale

Yayın Tarihi: 3/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001349817

pISSN: 0365-8104

Sayı

Yazarlar:

Berna Evranos Öğmen

Yayıncı:

Ankara University

Ana Başlıklar:

Ophthalmology | Endocrinology

Dergi:

Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.78 Issue 1, pp.8-12

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001349817

pISSN:

0365-8104