Evaluation of interleukin-23 receptor (IL-23R) gene polymorphisms and serum IL-23 levels in patients with psoriasis

Başak FİLİZ; Mehmet YILDIRIM; Kuyaş Hekimler ÖZTÜRK; Fevziye Burcu ŞİRİN; Seda ÇELİK; İjlal ERTURAN; Selma KORKMAZ; Hikmet ORHAN

Makale detayları

Evaluation of interleukin-23 receptor (IL-23R) gene polymorphisms and serum IL-23 levels in patients with psoriasis

Yazarlar:

Başak FİLİZ | Mehmet YILDIRIM | Kuyaş Hekimler ÖZTÜRK | Fevziye Burcu ŞİRİN | Seda ÇELİK | İjlal ERTURAN | Selma KORKMAZ | Hikmet ORHAN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 5, pp.1386-1394

Belge Tipi:

Makale

Yayın Tarihi:

9/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000749863

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: IL-23R gene polymorphisms and the association of these polymorphisms with serum IL-23 levels were investigated in patients with psoriasis in the current study. Materials  and  methods:  Sixty-seven  patients  with  psoriasis  who  were  admitted  to  our  dermatology  outpatient  clinic  and  67  healthy  controls were included in the study. Polymorphisms of the IL-23R gene were determined by KASP-PCR method, and serum IL-23 levels were determined by ELISA method.Results:  The  distribution  of  IL-23R  gene  polymorphisms  rs2201841,  rs11209026,  rs7530511,  rs1343152,  and  rs11465804  was  not  significantly  different  in  the  patient  and  control  groups.  The  AA  genotype  of  the  rs2201841  locus  in  males  and  the  GA  genotype  in  females, as well as the AA genotype of the rs1343152 locus in males and the CA genotype in females, were statistically significant in patients with psoriasis. The mean serum IL-23 level was significantly lower in the patient group (42.62 ± 5.96) compared to the control groups (75.76 ± 13.24). Conclusion: IL-23R gene polymorphisms including rs2201841, rs11209026, rs7530511, rs11465804, and rs1343152 were not found to be significantly related to psoriasis. Different genetic polymorphisms may play a role in the development of psoriasis in female and male populations. Ethnic differences between different populations may have led to differences in the distribution of polymorphisms in the current study with compared to other published studies. Additionally, many different genes, polymorphisms, and environmental factors that have an effect on the development of psoriasis may affect the disease process.

Makale detayları

Evaluation of interleukin-23 receptor (IL-23R) gene polymorphisms and serum IL-23 levels in patients with psoriasis

Yazarlar: Başak FİLİZ | Mehmet YILDIRIM | Kuyaş Hekimler ÖZTÜRK | Fevziye Burcu ŞİRİN | Seda ÇELİK | İjlal ERTURAN | Selma KORKMAZ | Hikmet ORHAN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2019 Vol.49 Issue 5, pp.1386-1394

Belge Tipi: Makale

Yayın Tarihi: 9/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000749863

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Başak FİLİZ | Mehmet YILDIRIM | Kuyaş Hekimler ÖZTÜRK | Fevziye Burcu ŞİRİN | Seda ÇELİK | İjlal ERTURAN | Selma KORKMAZ | Hikmet ORHAN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 5, pp.1386-1394

Belge Tipi:

Makale

Yayın Tarihi:

9/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000749863

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144