Evaluation of Inflammatory Markers in Patients with Hidraadenitis Suppurativa: A Single Center Case-Control Study

Özge Kaya; Havva Yasemin Çinpolat

Makale detayları

Evaluation of Inflammatory Markers in Patients with Hidraadenitis Suppurativa: A Single Center Case-Control Study

Yazarlar:

Özge Kaya | Havva Yasemin Çinpolat

Yayıncı:

Zonguldak Bulent Ecevit University

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Batı Karadeniz Tıp Dergisi Vol.7 Issue 2, pp.128-136

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001297874

pISSN:

2822-4302

Anahtar kelimeler:

Özet:

 Aim: In this study, it is aimed to evaluate monocyte: HDL ratio MHR, neutrophil: lymphocyte ratio NLR, monocyte: lymphocyte ratio MLR, which are new inflammatory markers, in HS. Material and Methods: Patients followed up with the diagnosis of HS between January 2012 and February 2023 and age-sex-matched healthy control group will be evaluated retrospectively in terms of sociodemographic findings age, gender, and laboratory findings high-density lipoprotein HDL,neutrophil count, monocyte count, erythrocyte sedimentation rate ESR, C-reactive protein CRP, MHR, NLR, MLR. The obtained data will be compared between the patient and control group. In addition, patients will be compared in terms of Hurley stage and the presence of metabolic syndrome. Results: 53 HS patients female: male ratio0.6:1, age mean33.3211.37 and 50 healthy controls female: male ratio0.47:1, age mean36.7411.95 were included in the study. While the mean HDL value was statistically lower in the patient group; ESR, neutrophil and monocyte counts, MHR, and NLR values were higher p0.05. When the patients were compared in terms of Hurley staging; neutrophil count, CRP, ESR, MHR, NLR ve MLR values, increased as the stage progressed, but this increase was statistically significant only at ESR p0.022. The number of anatomical localization involvement was positively correlated with the neutrophil count, monocyte count, ESR, MHR, NLR, MLR, and Hurley stage. Disease duration was correlated with MHR. Metabolic syndrome was present in 11 20.8  patients. While the MLR value was found to be lower in patients with metabolic syndrome, no statistical difference was found in other parameters. Conclusion: New inflammatory parameters such as MHR, NLR, and MLR can be used in daily practice in terms of reflecting the inflammatory burden in HS patients.

 Aim: In this study, it is aimed to evaluate monocyte: HDL ratio MHR, neutrophil: lymphocyte ratio NLR, monocyte: lymphocyte ratio MLR, which are new inflammatory markers, in HS. Material and Methods: Patients followed up with the diagnosis of HS between January 2012 and February 2023 and age-sex-matched healthy control group will be evaluated retrospectively in terms of sociodemographic findings age, gender, and laboratory findings high-density lipoprotein HDL,neutrophil count, monocyte count, erythrocyte sedimentation rate ESR, C-reactive protein CRP, MHR, NLR, MLR. The obtained data will be compared between the patient and control group. In addition, patients will be compared in terms of Hurley stage and the presence of metabolic syndrome. Results: 53 HS patients female: male ratio0.6:1, age mean33.3211.37 and 50 healthy controls female: male ratio0.47:1, age mean36.7411.95 were included in the study. While the mean HDL value was statistically lower in the patient group; ESR, neutrophil and monocyte counts, MHR, and NLR values were higher p0.05. When the patients were compared in terms of Hurley staging; neutrophil count, CRP, ESR, MHR, NLR ve MLR values, increased as the stage progressed, but this increase was statistically significant only at ESR p0.022. The number of anatomical localization involvement was positively correlated with the neutrophil count, monocyte count, ESR, MHR, NLR, MLR, and Hurley stage. Disease duration was correlated with MHR. Metabolic syndrome was present in 11 20.8  patients. While the MLR value was found to be lower in patients with metabolic syndrome, no statistical difference was found in other parameters. Conclusion: New inflammatory parameters such as MHR, NLR, and MLR can be used in daily practice in terms of reflecting the inflammatory burden in HS patients.

 Aim: In this study, it is aimed to evaluate monocyte: HDL ratio MHR, neutrophil: lymphocyte ratio NLR, monocyte: lymphocyte ratio MLR, which are new inflammatory markers, in HS. Material and Methods: Patients followed up with the diagnosis of HS between January 2012 and February 2023 and age-sex-matched healthy control group will be evaluated retrospectively in terms of sociodemographic findings age, gender, and laboratory findings high-density lipoprotein HDL,neutrophil count, monocyte count, erythrocyte sedimentation rate ESR, C-reactive protein CRP, MHR, NLR, MLR. The obtained data will be compared between the patient and control group. In addition, patients will be compared in terms of Hurley stage and the presence of metabolic syndrome. Results: 53 HS patients female: male ratio0.6:1, age mean33.3211.37 and 50 healthy controls female: male ratio0.47:1, age mean36.7411.95 were included in the study. While the mean HDL value was statistically lower in the patient group; ESR, neutrophil and monocyte counts, MHR, and NLR values were higher p0.05. When the patients were compared in terms of Hurley staging; neutrophil count, CRP, ESR, MHR, NLR ve MLR values, increased as the stage progressed, but this increase was statistically significant only at ESR p0.022. The number of anatomical localization involvement was positively correlated with the neutrophil count, monocyte count, ESR, MHR, NLR, MLR, and Hurley stage. Disease duration was correlated with MHR. Metabolic syndrome was present in 11 20.8  patients. While the MLR value was found to be lower in patients with metabolic syndrome, no statistical difference was found in other parameters. Conclusion: New inflammatory parameters such as MHR, NLR, and MLR can be used in daily practice in terms of reflecting the inflammatory burden in HS patients.

 Amaç: Hidradenitis suppurativa HS, kronik inflamatuar bir deri hastalığıdır. Bu çalışmada hidradenitis suppurativada yeni inflamatuar belirteçlerden olan monosit:HDL oranı monosit:HDL ratioMHR, nötrofil:lenfosit oranı nötrofil:lenfosit ratioNLR, monosit:lenfosit oranının monosit:lenfosit ratioMLR değerlendirilmesi amaçlanmaktadır. Gereç ve Yöntemler: Ocak 2012- Şubat 2023 tarihleri arasında HS tanısıyla takip edilen ve yaş-cinsiyet açısından eşleşmiş sağlıklı kontrol grubu sosyodemografik bulgular yaş, cinsiyet ve laboratuvar bulguları yüksek yoğunluklu lipoprotein high density lipoproteinHDL, nötrofil sayısı, monosit sayısı, eritrosit sedimantasyon hızı ESH, C-reaktif protein CRP, MHR, NLR, MLR açısından retrospektif olarak değerlendirildi. Elde edilen veriler hasta ve kontrol grubu arasında, ayrıca hasta grubunda hastalık şiddeti açısından Hurley evre 1, 2 ve 3 ve metabolik sendrom varlığına göre karşılaştırıldı. Ayrıca hasta grubunda inflamatuar belirteçlerle korele olan bulgular değerlendirildi. Bulgular: Çalışmaya 53 HS hastası kadın:erkek oranı0,6:1, yaş ort33.3211.37  ve 50 sağlıklı kontrol kadın:erkek oranı0,47:1, yaş ort36.7411.95 dahil edildi. Hasta grubunda ortalama HDL değeri istatistiksel olarak daha düşük saptanırken; ESH, nötrofil ve monosit sayıları, MHR ve NLR değerleri daha yüksekti p0.05. Hastalar Hurley evrelemesi açısından karşılaştırıldığında; CRP, ESH nötrofil ve monosit sayıları, MHR, NLR ve MLR değerleri evre ilerledikçe artmaktaydı, ancak bu artış sadece ESHnda istatistiksel olarak anlamlıydı p0.022. Anatomik lokalizasyon tutulum sayısı; nötrofil sayısı, monosit sayısı, ESH, MHR, NLR, MLR ve Hurley evresiyle pozitif koreleydi. Hastalık süresi ise MHR ile korelasyon göstermekteydi. Hastaların 11inde 20,8 metabolik sendrom mevcuttu. Metabolik sendromu olan hastalarda MLR değeri daha düşük saptanırken, diğer parametrelerde istatistiksel olarak anlamlı fark saptanmadı. Sonuç: HSte MHR, NLR ve MLR gibi maliyeti düşük ve kullanımı kolay olan yeni inflamatuar belirteçler inflamatuar yükü yansıtması açısından günlük pratikte kullanılabilecek parametrelerdir.

Makale detayları

Evaluation of Inflammatory Markers in Patients with Hidraadenitis Suppurativa: A Single Center Case-Control Study

Yazarlar:

Özge Kaya | Havva Yasemin Çinpolat

Yayıncı:

Zonguldak Bulent Ecevit University

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Batı Karadeniz Tıp Dergisi Vol.7 Issue 2, pp.128-136

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001297874

pISSN:

2822-4302

Hidradenitis suppurative

inflammation

metabolic syndrome

monocyte: HDL ratio

monocyte: lymphocyte ratio

neutrophil: lymphocyte ratioHidradenitis suppurativa

inflamasyon

metabolik sendrom

monosit:HDL oranı

monosit:lenfosit oranı

nötrofil:lenfosit oranı

Sayı

Makale detayları

Yazarlar: Özge Kaya | Havva Yasemin Çinpolat

Yayıncı: Zonguldak Bulent Ecevit University

Ana Başlıklar: Sağlık Kurumları Yönetimi

Dergi: Batı Karadeniz Tıp Dergisi Vol.7 Issue 2, pp.128-136

Belge Tipi: Makale

Yayın Tarihi: 8/2023

Belge Dili: Türkçe

Document ID (Org No.): 2001297874

pISSN: 2822-4302

Sayı

Yazarlar:

Özge Kaya | Havva Yasemin Çinpolat

Yayıncı:

Zonguldak Bulent Ecevit University

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Batı Karadeniz Tıp Dergisi Vol.7 Issue 2, pp.128-136

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001297874

pISSN:

2822-4302