Synthesis and Characterization of Natural Polymer Based Hydrogels

Ömer Faruk Güder; Betül Taşdelen; Uğur Akyol

Makale detayları

Synthesis and Characterization of Natural Polymer Based Hydrogels

Yazarlar:

Ömer Faruk Güder | Betül Taşdelen | Uğur Akyol

Yayıncı:

Tekirdag Namik Kemal University

Ana Başlıklar:

Biyomateryaller

Dergi:

European Journal of Engineering and Applied Sciences Vol.6 Issue 2, pp.111-119

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001303860

pISSN:

2651-3412

Anahtar kelimeler:

Özet:

 Soft tissue expanders, which have many uses in biomedical applications, are also encountered in surgical applications. Soft tissue expanders play an important role in ensuring osseointegration of dental implants. In this study, natural polymers chitosan CS, hyaluronic acid HA and gelatin GEL were used. Synthesis of CS, CS-HA, CS-GEL, GEL-HA and CS-HA-GEL hydrogels has been performed. Gamma radiation was used in hydrogel synthesis with HAP. They were characterized by Fourier Transform Infrared Spectroscopy FTIR and Scanning Electron Microscopy SEM. Dynamic swelling tests were performed in distilled water. Swelling behavior and swelling kinetics of hydrogels were determined. The effect of cross-linker concentration and different cross-linkers glutaraldehyde GA and hydroxyapatite HAP on swelling behavior was evaluated. Fickian mechanism has been observed in the diffusion of hydrogels. The results show that the hydrophilic CS-HA-1 hydrogel with the highest mass swelling and the most suitable swelling profile can be used as a soft tissue expander in biomedical applications.

 Soft tissue expanders, which have many uses in biomedical applications, are also encountered in surgical applications. Soft tissue expanders play an important role in ensuring osseointegration of dental implants. In this study, natural polymers chitosan CS, hyaluronic acid HA and gelatin GEL were used. Synthesis of CS, CS-HA, CS-GEL, GEL-HA and CS-HA-GEL hydrogels has been performed. Gamma radiation was used in hydrogel synthesis with HAP. They were characterized by Fourier Transform Infrared Spectroscopy FTIR and Scanning Electron Microscopy SEM. Dynamic swelling tests were performed in distilled water. Swelling behavior and swelling kinetics of hydrogels were determined. The effect of cross-linker concentration and different cross-linkers glutaraldehyde GA and hydroxyapatite HAP on swelling behavior was evaluated. Fickian mechanism has been observed in the diffusion of hydrogels. The results show that the hydrophilic CS-HA-1 hydrogel with the highest mass swelling and the most suitable swelling profile can be used as a soft tissue expander in biomedical applications.

 Soft tissue expanders, which have many uses in biomedical applications, are also encountered in surgical applications. Soft tissue expanders play an important role in ensuring osseointegration of dental implants. In this study, natural polymers chitosan CS, hyaluronic acid HA and gelatin GEL were used. Synthesis of CS, CS-HA, CS-GEL, GEL-HA and CS-HA-GEL hydrogels has been performed. Gamma radiation was used in hydrogel synthesis with HAP. They were characterized by Fourier Transform Infrared Spectroscopy FTIR and Scanning Electron Microscopy SEM. Dynamic swelling tests were performed in distilled water. Swelling behavior and swelling kinetics of hydrogels were determined. The effect of cross-linker concentration and different cross-linkers glutaraldehyde GA and hydroxyapatite HAP on swelling behavior was evaluated. Fickian mechanism has been observed in the diffusion of hydrogels. The results show that the hydrophilic CS-HA-1 hydrogel with the highest mass swelling and the most suitable swelling profile can be used as a soft tissue expander in biomedical applications.

 Biyomedikal uygulamalarda pek çok kullanımı bulunan yumuşak doku genişleticiler cerrahi uygulamalarda karşımıza çıkmaktadır. Dental implantların osseointegrasyonunun sağlanmasında yumuşak doku genişleticiler önemli bir rol oynamaktadır. Bu çalışmada, kitosan CS, hyaluronik asit HA ve jelatin GEL doğal polimerleri kullanılmıştır. CS, CS-HA, CS-GEL, GEL-HA ve CS-HA-GEL hidrojellerinin sentezi gerçekleştirilmiştir. HAP ile hidrojel sentezinde gama radyasyon kullanılmıştır. Fourier Dönüşümlü Kızılötesi Spektroskopisi FTIR ve Taramalı Elektron Mikroskobu SEM ile karakterizasyonları yapılmıştır. Dinamik şişme testleri distile suda gerçekleştirilmiştir. Hidrojellerin şişme davranışları ve şişme kinetikleri belirlenmiştir. Çapraz bağlayıcı konsantrasyonunun ve farklı çapraz bağlayıcıların glutaraldehit GA ve hidroksiapatit HAP şişme davranışına etkisi değerlendirilmiştir. Hidrojellerin difüzyonunda Fickian mekanizması görülmüştür. Sonuçlar, en yüksek kütlece şişmeye ve en uygun şişme profiline sahip hidrofilik yapılı CS-HA-1 hidrojelinin biyomedikal uygulamalarda yumuşak doku genişletici olarak kullanılabileceği göstermektedir..

Makale detayları

Synthesis and Characterization of Natural Polymer Based Hydrogels

Yazarlar:

Ömer Faruk Güder | Betül Taşdelen | Uğur Akyol

Yayıncı:

Tekirdag Namik Kemal University

Ana Başlıklar:

Biyomateryaller

Dergi:

European Journal of Engineering and Applied Sciences Vol.6 Issue 2, pp.111-119

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001303860

pISSN:

2651-3412

Hydrogel

Natural polymers

Soft tissue expansion

Tissue expanderDoğal polimerler

Doku genişletici

Hidrojel

Yumuşak doku genişlemesi

Sayı

Makale detayları

Yazarlar: Ömer Faruk Güder | Betül Taşdelen | Uğur Akyol

Yayıncı: Tekirdag Namik Kemal University

Ana Başlıklar: Biyomateryaller

Dergi: European Journal of Engineering and Applied Sciences Vol.6 Issue 2, pp.111-119

Belge Tipi: Makale

Yayın Tarihi: 12/2023

Belge Dili: Türkçe

Document ID (Org No.): 2001303860

pISSN: 2651-3412

Sayı

Yazarlar:

Ömer Faruk Güder | Betül Taşdelen | Uğur Akyol

Yayıncı:

Tekirdag Namik Kemal University

Ana Başlıklar:

Biyomateryaller

Dergi:

European Journal of Engineering and Applied Sciences Vol.6 Issue 2, pp.111-119

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001303860

pISSN:

2651-3412