Age and Gender Associated Changes in Cystatin C and b 2 -Microglobulin

Zuhal PARILDAR

Makale detayları

Age and Gender Associated Changes in Cystatin C and b 2 -Microglobulin

Yazarlar:

Zuhal PARILDAR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2002 Vol.32 Issue 4, pp.317-321

Belge Tipi:

Makale

Yayın Tarihi:

3/2002

Belge Dili:

Türkçe

Document ID (Org No.):

2000756948

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Assessment of renal function in clinical medicine is of great importance. Various studies report that cystatin C (cysC) and b 2 -microglobulin are valuable markers of renal function. In this study, serum cysC and b 2 -microglobulin were measured in parallel with serum creatinine in a healthy population, and the characteristics of the relationship of cysC and b 2 -microglobulin to age and gender were compared.  Serum creatinine, cysC and b2-microglobulin were measured in 119 (86 female; 33 male, 6 to 69 years old) healthy subjects. They were divided into five different age groups: group 1 (6-15 years, n = 10), group 2 (16-30 years, n = 34), group 3 (31-45 years, n = 34), group 4 (46-60 years, n = 29) and group 5 (>61 years, n = 12).  Serum creatinine did not differ among groups and was not correlated with age. Creatinine values were significantly different (p = 0.004) between males and females. CysC values differed neither by gender nor by age in the groups. However, cysC exhibited a positive correlation with age (r = 0.212, p = 0.021). b 2 -microglobulin levels showed a significant difference between groups (p = 0.036). There was a positive correlation between serum b 2 -microglobulin and age (r = 0.188, p = 0.041).  In conclusion, serum cysC and b 2 -microglobulin levels in healthy individuals increase with ageing, consistent with the decrease in GFR.

 

Assessment of renal function in clinical medicine is of great importance. Various studies report that cystatin C (cysC) and b 2 -microglobulin are valuable markers of renal function. In this study, serum cysC and b 2 -microglobulin were measured in parallel with serum creatinine in a healthy population, and the characteristics of the relationship of cysC and b 2 -microglobulin to age and gender were compared.  Serum creatinine, cysC and b2-microglobulin were measured in 119 (86 female; 33 male, 6 to 69 years old) healthy subjects. They were divided into five different age groups: group 1 (6-15 years, n = 10), group 2 (16-30 years, n = 34), group 3 (31-45 years, n = 34), group 4 (46-60 years, n = 29) and group 5 (>61 years, n = 12).  Serum creatinine did not differ among groups and was not correlated with age. Creatinine values were significantly different (p = 0.004) between males and females. CysC values differed neither by gender nor by age in the groups. However, cysC exhibited a positive correlation with age (r = 0.212, p = 0.021). b 2 -microglobulin levels showed a significant difference between groups (p = 0.036). There was a positive correlation between serum b 2 -microglobulin and age (r = 0.188, p = 0.041).  In conclusion, serum cysC and b 2 -microglobulin levels in healthy individuals increase with ageing, consistent with the decrease in GFR.

Makale detayları

Age and Gender Associated Changes in Cystatin C and b 2 -Microglobulin

Yazarlar:

Zuhal PARILDAR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2002 Vol.32 Issue 4, pp.317-321

Belge Tipi:

Makale

Yayın Tarihi:

3/2002

Belge Dili:

Türkçe

Document ID (Org No.):

2000756948

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Cystatin C

b 2 -microglobulin

glomerular filtration rate

ageing

Sayı

Makale detayları

Age and Gender Associated Changes in Cystatin C and b 2 -Microglobulin

Yazarlar: Zuhal PARILDAR

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2002 Vol.32 Issue 4, pp.317-321

Belge Tipi: Makale

Yayın Tarihi: 3/2002

Belge Dili: Türkçe

Document ID (Org No.): 2000756948

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Cystatin C

b 2 -microglobulin

glomerular filtration rate

ageing

Sayı

Yazarlar:

Zuhal PARILDAR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2002 Vol.32 Issue 4, pp.317-321

Belge Tipi:

Makale

Yayın Tarihi:

3/2002

Belge Dili:

Türkçe

Document ID (Org No.):

2000756948

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144