In vitro antibacterial activity of eravacycline against multidrug-resistant Acinetobacter baumannii isolates

Merve Ataman; Emel Mataracı Kara; Berna Özbek Çelik

Makale detayları

In vitro antibacterial activity of eravacycline against multidrug-resistant Acinetobacter baumannii isolates

Yazarlar:

Merve Ataman | Emel Mataracı Kara | Berna Özbek Çelik

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Microbiology

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 5, pp.549-553

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346220

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 The antibacterial effectiveness of eravacycline was compared with various antibiotics used in Acinetobacter therapy against multidrug-resistant MDR Acinetobacter baumannii strains. Antibacterial susceptibility studiea was achieved by the broth microdilution method against 52 nonduplicate, A. baumanniii strains to eravacycline, tobramycin, levofloxacin, cefepime, meropenem, and colistin. Eravacycline presented greater action than the comparators of the other group, cefepime, colistin, levofloxacin, and tobramycin. While the MIC5090 values of eravacycline were 816 mgL and those for tobramycin, levofloxacin, cefepime, meropenem, and colistin were found 256256, 64256, 256256, 128256, and 0.5256 mgL, respectively. As a result, the present study showed that eravacycline was a potent effective antibiotic against MDR A. baumannii. Eravacycline could be an effective new alternative for use in particular, for the treatment of this problematic organism.a.

 The antibacterial effectiveness of eravacycline was compared with various antibiotics used in Acinetobacter therapy against multidrug-resistant MDR Acinetobacter baumannii strains. Antibacterial susceptibility studiea was achieved by the broth microdilution method against 52 nonduplicate, A. baumanniii strains to eravacycline, tobramycin, levofloxacin, cefepime, meropenem, and colistin. Eravacycline presented greater action than the comparators of the other group, cefepime, colistin, levofloxacin, and tobramycin. While the MIC5090 values of eravacycline were 816 mgL and those for tobramycin, levofloxacin, cefepime, meropenem, and colistin were found 256256, 64256, 256256, 128256, and 0.5256 mgL, respectively. As a result, the present study showed that eravacycline was a potent effective antibiotic against MDR A. baumannii. Eravacycline could be an effective new alternative for use in particular, for the treatment of this problematic organism.a.

 The antibacterial effectiveness of eravacycline was compared with various antibiotics used in Acinetobacter therapy against multidrug-resistant MDR Acinetobacter baumannii strains. Antibacterial susceptibility studiea was achieved by the broth microdilution method against 52 nonduplicate, A. baumanniii strains to eravacycline, tobramycin, levofloxacin, cefepime, meropenem, and colistin. Eravacycline presented greater action than the comparators of the other group, cefepime, colistin, levofloxacin, and tobramycin. While the MIC5090 values of eravacycline were 816 mgL and those for tobramycin, levofloxacin, cefepime, meropenem, and colistin were found 256256, 64256, 256256, 128256, and 0.5256 mgL, respectively. As a result, the present study showed that eravacycline was a potent effective antibiotic against MDR A. baumannii. Eravacycline could be an effective new alternative for use in particular, for the treatment of this problematic organism.a.

 The antibacterial effectiveness of eravacycline was compared with various antibiotics used in Acinetobacter therapy against multidrug-resistant MDR Acinetobacter baumannii strains. Antibacterial susceptibility studiea was achieved by the broth microdilution method against 52 nonduplicate, A. baumanniii strains to eravacycline, tobramycin, levofloxacin, cefepime, meropenem, and colistin. Eravacycline presented greater action than the comparators of the other group, cefepime, colistin, levofloxacin, and tobramycin. While the MIC5090 values of eravacycline were 816 mgL and those for tobramycin, levofloxacin, cefepime, meropenem, and colistin were found 256256, 64256, 256256, 128256, and 0.5256 mgL, respectively. As a result, the present study showed that eravacycline was a potent effective antibiotic against MDR A. baumannii. Eravacycline could be an effective new alternative for use in particular, for the treatment of this problematic organism.a.

Makale detayları

In vitro antibacterial activity of eravacycline against multidrug-resistant Acinetobacter baumannii isolates

Yazarlar:

Merve Ataman | Emel Mataracı Kara | Berna Özbek Çelik

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Microbiology

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 5, pp.549-553

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346220

pISSN:

2630-6344

Non-fermentative

tetracycline

antibacterial agent

resistant bacteria

MIC

Sayı

Makale detayları

In vitro antibacterial activity of eravacycline against multidrug-resistant Acinetobacter baumannii isolates

Yazarlar: Merve Ataman | Emel Mataracı Kara | Berna Özbek Çelik

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Microbiology

Dergi: Journal of Research in Pharmacy Vol.25 Issue 5, pp.549-553

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346220

pISSN: 2630-6344

Non-fermentative

tetracycline

antibacterial agent

resistant bacteria

MIC

Sayı

Yazarlar:

Merve Ataman | Emel Mataracı Kara | Berna Özbek Çelik

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Microbiology

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 5, pp.549-553

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346220

pISSN:

2630-6344