Effects of Ozone Threapy as an Adjunct to Non-Surgical Periodontal Treatment on Clinical Periodontal Parameters and Inflammatory Markers in Periodontitis Patients

Sema Nur Sevinç Gül; Alparslan Dilsiz; Mehmet Ali Gül

Makale detayları

Effects of Ozone Threapy as an Adjunct to Non-Surgical Periodontal Treatment on Clinical Periodontal Parameters and Inflammatory Markers in Periodontitis Patients

Yazarlar:

Sema Nur Sevinç Gül | Alparslan Dilsiz | Mehmet Ali Gül

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Dentistry (Other)

Dergi:

Meandros Medical And Dental Journal Vol.24 Issue 2, pp.119-124

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001348384

pISSN:

2149-9063

Anahtar kelimeler:

Özet:

 Objective: Ozone therapy OT is known to eliminate pathogens in the periodontal pocket and accelerate wound healing. This study aimed to investigate the clinical and biochemical efficacy of OT as adjunctive scaling and root planning SRP in the treatment of periodontitis. Materials and Methods: Fifty systemically healthy individuals with periodontitis were included in this study. Gingival crevicular fluid GCF samples were taken from the patients before and 8 weeks after starting the treatment, and gingival index GI, plaque index PI, bleeding on probing BOP, pocket depth PD, and clinical attachment level CAL were obtained from all subjects. Non-surgical periodontal treatment was applied to the test and control groups, and gaseous ozone treatment was applied in addition to the test group. TNF-α, IL-1β, IL-6, IL-10, and MMP-9 values in GCF samples before and after treatment were determined by the ELISA method and evaluated statistically. Results: Both groups presented significantly decreased clinical periodontal parameters at 8-week from baseline p0.05. Clinical periodontal parameters were found to be significantly lower in the test group than In the control group, there was a decrease in TNF-α levels after non-surgical periodontal treatment p0.05. Both groups demonstrated significantly decreased IL-1β, IL-6, IL-10, and MMP-9 levels at 8-week p0.05. The test group showed a significant decrease in MMP-9 levels compared with the control group at 8-week p0.05. Conclusion: As a result of the close relationship observed between clinical periodontal measurements and biochemical parameters, it was observed that clinical periodontal healing affects biochemical parameters, and in addition to non-surgical periodontal treatment, ozone treatment improves clinical periodontal measurements and affects biochemical parameters by reducing the GCF volume.

 Objective: Ozone therapy OT is known to eliminate pathogens in the periodontal pocket and accelerate wound healing. This study aimed to investigate the clinical and biochemical efficacy of OT as adjunctive scaling and root planning SRP in the treatment of periodontitis. Materials and Methods: Fifty systemically healthy individuals with periodontitis were included in this study. Gingival crevicular fluid GCF samples were taken from the patients before and 8 weeks after starting the treatment, and gingival index GI, plaque index PI, bleeding on probing BOP, pocket depth PD, and clinical attachment level CAL were obtained from all subjects. Non-surgical periodontal treatment was applied to the test and control groups, and gaseous ozone treatment was applied in addition to the test group. TNF-α, IL-1β, IL-6, IL-10, and MMP-9 values in GCF samples before and after treatment were determined by the ELISA method and evaluated statistically. Results: Both groups presented significantly decreased clinical periodontal parameters at 8-week from baseline p0.05. Clinical periodontal parameters were found to be significantly lower in the test group than In the control group, there was a decrease in TNF-α levels after non-surgical periodontal treatment p0.05. Both groups demonstrated significantly decreased IL-1β, IL-6, IL-10, and MMP-9 levels at 8-week p0.05. The test group showed a significant decrease in MMP-9 levels compared with the control group at 8-week p0.05. Conclusion: As a result of the close relationship observed between clinical periodontal measurements and biochemical parameters, it was observed that clinical periodontal healing affects biochemical parameters, and in addition to non-surgical periodontal treatment, ozone treatment improves clinical periodontal measurements and affects biochemical parameters by reducing the GCF volume.

 Objective: Ozone therapy OT is known to eliminate pathogens in the periodontal pocket and accelerate wound healing. This study aimed to investigate the clinical and biochemical efficacy of OT as adjunctive scaling and root planning SRP in the treatment of periodontitis. Materials and Methods: Fifty systemically healthy individuals with periodontitis were included in this study. Gingival crevicular fluid GCF samples were taken from the patients before and 8 weeks after starting the treatment, and gingival index GI, plaque index PI, bleeding on probing BOP, pocket depth PD, and clinical attachment level CAL were obtained from all subjects. Non-surgical periodontal treatment was applied to the test and control groups, and gaseous ozone treatment was applied in addition to the test group. TNF-α, IL-1β, IL-6, IL-10, and MMP-9 values in GCF samples before and after treatment were determined by the ELISA method and evaluated statistically. Results: Both groups presented significantly decreased clinical periodontal parameters at 8-week from baseline p0.05. Clinical periodontal parameters were found to be significantly lower in the test group than In the control group, there was a decrease in TNF-α levels after non-surgical periodontal treatment p0.05. Both groups demonstrated significantly decreased IL-1β, IL-6, IL-10, and MMP-9 levels at 8-week p0.05. The test group showed a significant decrease in MMP-9 levels compared with the control group at 8-week p0.05. Conclusion: As a result of the close relationship observed between clinical periodontal measurements and biochemical parameters, it was observed that clinical periodontal healing affects biochemical parameters, and in addition to non-surgical periodontal treatment, ozone treatment improves clinical periodontal measurements and affects biochemical parameters by reducing the GCF volume.

 Objective: Ozone therapy OT is known to eliminate pathogens in the periodontal pocket and accelerate wound healing. This study aimed to investigate the clinical and biochemical efficacy of OT as adjunctive scaling and root planning SRP in the treatment of periodontitis. Materials and Methods: Fifty systemically healthy individuals with periodontitis were included in this study. Gingival crevicular fluid GCF samples were taken from the patients before and 8 weeks after starting the treatment, and gingival index GI, plaque index PI, bleeding on probing BOP, pocket depth PD, and clinical attachment level CAL were obtained from all subjects. Non-surgical periodontal treatment was applied to the test and control groups, and gaseous ozone treatment was applied in addition to the test group. TNF-α, IL-1β, IL-6, IL-10, and MMP-9 values in GCF samples before and after treatment were determined by the ELISA method and evaluated statistically. Results: Both groups presented significantly decreased clinical periodontal parameters at 8-week from baseline p0.05. Clinical periodontal parameters were found to be significantly lower in the test group than In the control group, there was a decrease in TNF-α levels after non-surgical periodontal treatment p0.05. Both groups demonstrated significantly decreased IL-1β, IL-6, IL-10, and MMP-9 levels at 8-week p0.05. The test group showed a significant decrease in MMP-9 levels compared with the control group at 8-week p0.05. Conclusion: As a result of the close relationship observed between clinical periodontal measurements and biochemical parameters, it was observed that clinical periodontal healing affects biochemical parameters, and in addition to non-surgical periodontal treatment, ozone treatment improves clinical periodontal measurements and affects biochemical parameters by reducing the GCF volume.

Makale detayları

Effects of Ozone Threapy as an Adjunct to Non-Surgical Periodontal Treatment on Clinical Periodontal Parameters and Inflammatory Markers in Periodontitis Patients

Yazarlar:

Sema Nur Sevinç Gül | Alparslan Dilsiz | Mehmet Ali Gül

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Dentistry (Other)

Dergi:

Meandros Medical And Dental Journal Vol.24 Issue 2, pp.119-124

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001348384

pISSN:

2149-9063

Periodontitis

cytokines

inflammation

matrix metalloproteinases

ozone

periodontal debridement

Sayı

Makale detayları

Effects of Ozone Threapy as an Adjunct to Non-Surgical Periodontal Treatment on Clinical Periodontal Parameters and Inflammatory Markers in Periodontitis Patients

Yazarlar: Sema Nur Sevinç Gül | Alparslan Dilsiz | Mehmet Ali Gül

Yayıncı: Aydin Adnan Menderes University

Ana Başlıklar: Dentistry (Other)

Dergi: Meandros Medical And Dental Journal Vol.24 Issue 2, pp.119-124

Belge Tipi: Makale

Yayın Tarihi: 6/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001348384

pISSN: 2149-9063

Periodontitis

cytokines

inflammation

matrix metalloproteinases

ozone

periodontal debridement

Sayı

Yazarlar:

Sema Nur Sevinç Gül | Alparslan Dilsiz | Mehmet Ali Gül

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Dentistry (Other)

Dergi:

Meandros Medical And Dental Journal Vol.24 Issue 2, pp.119-124

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001348384

pISSN:

2149-9063