Investigation of serum paraoxonase-1 activity and lipid levels in patients with hyperthyroidism

Gülden BAŞKOL; Kıymet DOLBUN SEÇKİN; Fahri BAYRAM; Fatih TANRIVERDİ

Makale detayları

Investigation of serum paraoxonase-1 activity and lipid levels in patients with hyperthyroidism

Yazarlar:

Gülden BAŞKOL | Kıymet DOLBUN SEÇKİN | Fahri BAYRAM | Fatih TANRIVERDİ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2012 Vol.42 Issue Sup.1, pp.1166-1171

Belge Tipi:

Makale

Yayın Tarihi:

11/2011

Belge Dili:

Türkçe

Document ID (Org No.):

2000754335

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

The present study was designed to investigate the relationship among the serum paraoxonase-1 (PON-1) activity, lipid levels, and thyroid hormone status in patients with hyperthyroidism.  Materials and methods: The study group comprised 30 patients with primary hyperthyroidism and 18 normal healthy controls who were matched for age and sex. Serum PON-1 activity was determined by spectrophotometric methods.    Results: Serum PON-1 activity was found to be lower in patients compared to controls (P  0.05). Serum PON-1 activity was found to be negatively correlated with free T4 levels (r = -0.324, P < 0.05) and positively correlated with total cholesterol (r = 0.330, P < 0.05) and TSH levels (r = 0.577, P < 0.001).  Conclusion: Our PON-1 results show that there is decreased antioxidant defense in patients with hyperthyroidism. Therefore, we think that effective antioxidant therapy to increase PON-1 activity may be a therapeutic option in patients with hyperthyroidism.

 

The present study was designed to investigate the relationship among the serum paraoxonase-1 (PON-1) activity, lipid levels, and thyroid hormone status in patients with hyperthyroidism.  Materials and methods: The study group comprised 30 patients with primary hyperthyroidism and 18 normal healthy controls who were matched for age and sex. Serum PON-1 activity was determined by spectrophotometric methods.    Results: Serum PON-1 activity was found to be lower in patients compared to controls (P  0.05). Serum PON-1 activity was found to be negatively correlated with free T4 levels (r = -0.324, P < 0.05) and positively correlated with total cholesterol (r = 0.330, P < 0.05) and TSH levels (r = 0.577, P < 0.001).  Conclusion: Our PON-1 results show that there is decreased antioxidant defense in patients with hyperthyroidism. Therefore, we think that effective antioxidant therapy to increase PON-1 activity may be a therapeutic option in patients with hyperthyroidism.

Makale detayları

Investigation of serum paraoxonase-1 activity and lipid levels in patients with hyperthyroidism

Yazarlar:

Gülden BAŞKOL | Kıymet DOLBUN SEÇKİN | Fahri BAYRAM | Fatih TANRIVERDİ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2012 Vol.42 Issue Sup.1, pp.1166-1171

Belge Tipi:

Makale

Yayın Tarihi:

11/2011

Belge Dili:

Türkçe

Document ID (Org No.):

2000754335

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Key words: Paraoxonase-1 activity

oxidative stress

hyperthyroidism

Sayı

Makale detayları

Investigation of serum paraoxonase-1 activity and lipid levels in patients with hyperthyroidism

Yazarlar: Gülden BAŞKOL | Kıymet DOLBUN SEÇKİN | Fahri BAYRAM | Fatih TANRIVERDİ

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2012 Vol.42 Issue Sup.1, pp.1166-1171

Belge Tipi: Makale

Yayın Tarihi: 11/2011

Belge Dili: Türkçe

Document ID (Org No.): 2000754335

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Key words: Paraoxonase-1 activity

oxidative stress

hyperthyroidism

Sayı

Yazarlar:

Gülden BAŞKOL | Kıymet DOLBUN SEÇKİN | Fahri BAYRAM | Fatih TANRIVERDİ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2012 Vol.42 Issue Sup.1, pp.1166-1171

Belge Tipi:

Makale

Yayın Tarihi:

11/2011

Belge Dili:

Türkçe

Document ID (Org No.):

2000754335

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144