Allergic and autoimmune disorders in families with selective IgA deficiency

Mustafa ERKOÇOĞLU; Ayşe METİN; Ayşenur KAYA; Celal ÖZCAN; Ayşegül AKAN; Ersoy CİVELEK; Murat ÇAPANOĞLU; Tayfur GİNİŞ; Can Naci KOCABAŞ

Makale detayları

Allergic and autoimmune disorders in families with selective IgA deficiency

Yazarlar:

Mustafa ERKOÇOĞLU | Ayşe METİN | Ayşenur KAYA | Celal ÖZCAN | Ayşegül AKAN | Ersoy CİVELEK | Murat ÇAPANOĞLU | Tayfur GİNİŞ | Can Naci KOCABAŞ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 2, pp.592-598

Belge Tipi:

Makale

Yayın Tarihi:

3/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000751463

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: IgA deficiency is the most common human primary immunodeficiency. The prevalence of allergic disorders and  autoimmunity is thought to be increased in selective IgA deficiency (sIgAD). However, it is currently unclear if these disorders coincide  within these families. We aimed to evaluate the frequency of allergic and autoimmune disorders in children with sIgAD and their firstdegree  relatives (FDRs).  Materials and methods: The study included 81 children diagnosed with sIgAD and 274 of their FDRs. The presence of allergic and  autoimmune disorders was evaluated and serum antithyroglobulin and antithyroid peroxidase levels were measured in both patients  and their first-degree relatives.  Results: The mean age of the patients was 9.9 ± 3.9 years. Among the patients with sIgAD, 45.7% of them had at least one allergic  disorder and 17.3% of them had at least one autoimmune disorder. The frequencies of asthma, allergic rhinitis, and eczema in the FDRs  of sIgAD patients were 10.9%, 9.1%, and 7.7%, respectively. Among their FDRs, 14.6% had autoimmunity, compared to an estimate of  5% in the general population.  Conclusion: Increased frequency of allergic and autoimmune disorders in patients with sIgAD and their FDRs suggests a possible  common predisposing genetic component for sIgAD and autoimmunity in these families.

Makale detayları

Allergic and autoimmune disorders in families with selective IgA deficiency

Yazarlar: Mustafa ERKOÇOĞLU | Ayşe METİN | Ayşenur KAYA | Celal ÖZCAN | Ayşegül AKAN | Ersoy CİVELEK | Murat ÇAPANOĞLU | Tayfur GİNİŞ | Can Naci KOCABAŞ

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2017 Vol.47 Issue 2, pp.592-598

Belge Tipi: Makale

Yayın Tarihi: 3/2017

Belge Dili: Türkçe

Document ID (Org No.): 2000751463

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Mustafa ERKOÇOĞLU | Ayşe METİN | Ayşenur KAYA | Celal ÖZCAN | Ayşegül AKAN | Ersoy CİVELEK | Murat ÇAPANOĞLU | Tayfur GİNİŞ | Can Naci KOCABAŞ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 2, pp.592-598

Belge Tipi:

Makale

Yayın Tarihi:

3/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000751463

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144