Chemical and biotransformation of Gelomulide F: a rare diterpene lactone

Humaira Yasmeen GONDAL; And Muhammad Iqbal CHOUDHARY

Makale detayları

Chemical and biotransformation of Gelomulide F: a rare diterpene lactone

Yazarlar:

Humaira Yasmeen GONDAL | And Muhammad Iqbal CHOUDHARY

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2012 Vol.36 Issue 5, pp.759-763

Belge Tipi:

Makale

Yayın Tarihi:

4/2012

Belge Dili:

Türkçe

Document ID (Org No.):

2000727564

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

Chemical and biotransformations of a rare diterpene lactone,  Gelomulide F (1), from the cytotoxic extract of leaves of Suregada  multiflora were studied.  Fermentation of compound 1 with Sachromyces  cerevisiae transformed it to Gelomulide D (2) and E (3), whereas its  treatment with 2N KOH yielded Gelomulide D (2).  In addition, a novel  compound (4) was obtained by its diastereo and chemoselective  reduction with NaBH4.  All of these compounds were characterized on  the basis of extensive 1H-NMR, 13C-NMR, 2D NMR, and mass spectral  analyses.

 

Chemical and biotransformations of a rare diterpene lactone,  Gelomulide F (1), from the cytotoxic extract of leaves of Suregada  multiflora were studied.  Fermentation of compound 1 with Sachromyces  cerevisiae transformed it to Gelomulide D (2) and E (3), whereas its  treatment with 2N KOH yielded Gelomulide D (2).  In addition, a novel  compound (4) was obtained by its diastereo and chemoselective  reduction with NaBH4.  All of these compounds were characterized on  the basis of extensive 1H-NMR, 13C-NMR, 2D NMR, and mass spectral  analyses.

Makale detayları

Chemical and biotransformation of Gelomulide F: a rare diterpene lactone

Yazarlar: Humaira Yasmeen GONDAL | And Muhammad Iqbal CHOUDHARY

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2012 Vol.36 Issue 5, pp.759-763

Belge Tipi: Makale

Yayın Tarihi: 4/2012

Belge Dili: Türkçe

Document ID (Org No.): 2000727564

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Humaira Yasmeen GONDAL | And Muhammad Iqbal CHOUDHARY

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2012 Vol.36 Issue 5, pp.759-763

Belge Tipi:

Makale

Yayın Tarihi:

4/2012

Belge Dili:

Türkçe

Document ID (Org No.):

2000727564

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527