SIÇAN TİROİD BEZİNDE KADMİYUM HASARINA KARŞI C VİTAMİNİ, E VİTAMİNİ VE SELENYUMUN KOMBİNE KULLANIMININ ETKİLERİ

Ömür KARABULUT BULAN; Meral KOYUTÜRK; Şehnaz BOLKENT; Refiye YANARDAĞ; Ayşe TABAKOĞLU OĞUZ

Makale detayları

SIÇAN TİROİD BEZİNDE KADMİYUM HASARINA KARŞI C VİTAMİNİ, E VİTAMİNİ VE SELENYUMUN KOMBİNE KULLANIMININ ETKİLERİ

Yazarlar:

Ömür KARABULUT BULAN | Meral KOYUTÜRK | Şehnaz BOLKENT | Refiye YANARDAĞ | Ayşe TABAKOĞLU OĞUZ

Yayıncı:

İstanbul University-Cerrahpasa

Dergi:

Cerrahpaşa Tıp Dergisi 2004 Vol.35 Issue 4

Belge Tipi:

Makale

Yayın Tarihi:

7/2014

Belge Dili:

Türkçe

Document ID (Org No.):

2000766293

Sıklık:

Üç Aylık

pISSN:

1300-5227

Anahtar kelimeler:

-

Özet:

 


Background and Design.- Histopathological alterations to various organs of the different species in acute and chronic cadmium exposure have been studied by light and electron microscopy. Metallothionein is a protein inducible by heavy metal ions. The aim of this study was to determine the effects of vitamin C, vitamin E and selenium combination on the cadmium-induced morphological and immunohistochemical changes in the thyroid gland of adult male rats.

Results.- In the group given cadmium, the degenerative changes were observed in the thyroid gland. In addition, an increase in the number of metallothionein positive cells was detected in this group. These immunoreactive cells were identified as mast cells. While these degenerative changes and metallothionein immunoreactive cells in the thyroid gland were decreased in the group given cadmium and antioxidants according to the experimental group.

Conclusion.- These results suggest that metallothionein participate in accumulation of cadmium in rats, since thyroid gland containing a lot of metallothionein positive cells show a tendency to accumulate of cadmium. In addition, the combination of vitamin C, vitamin E and selenium shows a protective effect against cadmium induced oxidative injury of thyroid gland. Antioxidants also may participate to regulation of the metallothionein expression.

*Anahtar Kelimeler: Antioksidanlar, kadmiyum, metallotionein, sıçan, tiroid

*Key Words: Antioxidants, cadmium, metallothionein, rat, thyroid

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Makale detayları

SIÇAN TİROİD BEZİNDE KADMİYUM HASARINA KARŞI C VİTAMİNİ, E VİTAMİNİ VE SELENYUMUN KOMBİNE KULLANIMININ ETKİLERİ

Yazarlar: Ömür KARABULUT BULAN | Meral KOYUTÜRK | Şehnaz BOLKENT | Refiye YANARDAĞ | Ayşe TABAKOĞLU OĞUZ

Yayıncı: İstanbul University-Cerrahpasa

Dergi: Cerrahpaşa Tıp Dergisi 2004 Vol.35 Issue 4

Belge Tipi: Makale

Yayın Tarihi: 7/2014

Belge Dili: Türkçe

Document ID (Org No.): 2000766293

Sıklık: Üç Aylık

pISSN: 1300-5227

-

Sayı

Yazarlar:

Ömür KARABULUT BULAN | Meral KOYUTÜRK | Şehnaz BOLKENT | Refiye YANARDAĞ | Ayşe TABAKOĞLU OĞUZ

Yayıncı:

İstanbul University-Cerrahpasa

Dergi:

Cerrahpaşa Tıp Dergisi 2004 Vol.35 Issue 4

Belge Tipi:

Makale

Yayın Tarihi:

7/2014

Belge Dili:

Türkçe

Document ID (Org No.):

2000766293

Sıklık:

Üç Aylık

pISSN:

1300-5227