The Gluten-Casein-Free Diet in Children with Autism: A Clinical Results of the Ophthalmic and Behavioral Manifestations

Öznur Özge Özcan; İbrahim Şahbaz; Emre Taşdöndüren; Mesut Karahan

Makale detayları

The Gluten-Casein-Free Diet in Children with Autism: A Clinical Results of the Ophthalmic and Behavioral Manifestations

Yazarlar:

Öznur Özge Özcan | İbrahim Şahbaz | Emre Taşdöndüren | Mesut Karahan

Yayıncı:

İstanbul Gelisim University

Ana Başlıklar:

Klinik Beslenme

Dergi:

İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi Issue 21, pp.828-842

Belge Tipi:

Makale

Yayın Tarihi:

5/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001308775

pISSN:

2536-4499

Anahtar kelimeler:

Özet:

 Aim: To evaluate the ophthalmic and behavioral effects of a gluten-free casein-free diet GCFD in autism spectrum disorder ASD. Method: The study was conducted from November 2020 to January 2023. We designed an 8-week clinical trial of GCFD on corneal reflex, pupil size, body mass index BMI, weight, Autistic Disorder Index, Communication, Social interaction, and Stereotype Behavior. Results: A total of thirty participants completed the trial. GCFD reduced BMI 95 CI -4.8895 to -2.1305 P  0.0001, weight 95 CI -8.5153 to -0.0647 P  0.0467, Autistic Disorder Index 95 CI -28.0359 to -16.2841 P  0.0001, Communication 95 CI -3.3325 to -1.6675 P  0.0001, Social Interaction 95 CI -4.3190 to -2.4010 P  0.0001, and Stereotype Behavior 95 CI -2.3939 to -0.2461 P 0.01 significantly. GCFD also reduced left 95 CI -2.2421 to -1.6779 P 0.0001 and right pupil size 95 CI -2.2999 to -1.7201 P 0.0001 significantly. Conversely, corneal reflex was significantly increased 95 CI 0.2159 to 2.1241 P  0.01. No differences were observed for IPD. Conclusion: This study suggested that the GCFD can effectively control ASD behaviors as well as regulate autonomic functions related to ophthalmic markers such as pupil size and corneal reflex, but more research is needed.

 Aim: To evaluate the ophthalmic and behavioral effects of a gluten-free casein-free diet GCFD in autism spectrum disorder ASD. Method: The study was conducted from November 2020 to January 2023. We designed an 8-week clinical trial of GCFD on corneal reflex, pupil size, body mass index BMI, weight, Autistic Disorder Index, Communication, Social interaction, and Stereotype Behavior. Results: A total of thirty participants completed the trial. GCFD reduced BMI 95 CI -4.8895 to -2.1305 P  0.0001, weight 95 CI -8.5153 to -0.0647 P  0.0467, Autistic Disorder Index 95 CI -28.0359 to -16.2841 P  0.0001, Communication 95 CI -3.3325 to -1.6675 P  0.0001, Social Interaction 95 CI -4.3190 to -2.4010 P  0.0001, and Stereotype Behavior 95 CI -2.3939 to -0.2461 P 0.01 significantly. GCFD also reduced left 95 CI -2.2421 to -1.6779 P 0.0001 and right pupil size 95 CI -2.2999 to -1.7201 P 0.0001 significantly. Conversely, corneal reflex was significantly increased 95 CI 0.2159 to 2.1241 P  0.01. No differences were observed for IPD. Conclusion: This study suggested that the GCFD can effectively control ASD behaviors as well as regulate autonomic functions related to ophthalmic markers such as pupil size and corneal reflex, but more research is needed.

 Aim: To evaluate the ophthalmic and behavioral effects of a gluten-free casein-free diet GCFD in autism spectrum disorder ASD. Method: The study was conducted from November 2020 to January 2023. We designed an 8-week clinical trial of GCFD on corneal reflex, pupil size, body mass index BMI, weight, Autistic Disorder Index, Communication, Social interaction, and Stereotype Behavior. Results: A total of thirty participants completed the trial. GCFD reduced BMI 95 CI -4.8895 to -2.1305 P  0.0001, weight 95 CI -8.5153 to -0.0647 P  0.0467, Autistic Disorder Index 95 CI -28.0359 to -16.2841 P  0.0001, Communication 95 CI -3.3325 to -1.6675 P  0.0001, Social Interaction 95 CI -4.3190 to -2.4010 P  0.0001, and Stereotype Behavior 95 CI -2.3939 to -0.2461 P 0.01 significantly. GCFD also reduced left 95 CI -2.2421 to -1.6779 P 0.0001 and right pupil size 95 CI -2.2999 to -1.7201 P 0.0001 significantly. Conversely, corneal reflex was significantly increased 95 CI 0.2159 to 2.1241 P  0.01. No differences were observed for IPD. Conclusion: This study suggested that the GCFD can effectively control ASD behaviors as well as regulate autonomic functions related to ophthalmic markers such as pupil size and corneal reflex, but more research is needed.

 Amaç: Otizm spektrum bozukluğunda ASD glutensiz kazeinsiz diyetin GCFD oftalmik ve davranışsal etkilerini değerlendirmektir. Yöntem: Çalışma Kasım 2020den Ocak 2023e kadar gerçekleştirildi. Kornea refleksi, gözbebeği büyüklüğü, vücut kitle indeksi BMI, ağırlık, Otistik Bozukluk İndeksi, İletişim, Sosyal Etkileşim ve Stereotip Davranış üzerinde GCFDnin 8 haftalık bir klinik çalışması yapıldı. Bulgular: Çalışmaya toplamda 30 çocuk dahil edildi. GCFD, BKİyi 95 CI 4,8895 ile -2,1305 P  0,0001, ağırlığı 95 CI -8,5153 ila -0,0647 P  0,0467, Otistik Bozukluk İndeksini 95 CI -28.0359 to -16.2841 P  0.0001, İletişim 95 CI 3,3325 ila -1,6675 P  0,0001, Sosyal etkileşim 95 CI -4,3190 ila -2,4010 P  0,0001 ve Stereotip Davranışı 95 CI -2,3939 ila -0,2461 P 0,01 önemli ölçüde azalttı. GCFD ayrıca soldaki 95 CI -2,2421 ila -1,6779 P 0,0001 ve sağ gözbebeği boyutunu 95 CI -2,2999 ila -1,7201 P 0,0001 önemli ölçüde azalttı. Tersine, kornea refleksi önemli ölçüde arttı 95 CI 0,2159 - 2,1241 P  0,01. IPD için hiçbir fark gözlenmedi. Sonuç: Bu çalışma, GCFDnin OSB davranışlarını etkili bir şekilde kontrol edebileceğini ve ayrıca gözbebeği boyutu ve kornea refleksi gibi oftalmik belirteçlerle ilgili otonomik işlevleri düzenleyebileceğini göstermiştir ancak daha fazla araştırmaya ihtiyaç vardır.

Makale detayları

The Gluten-Casein-Free Diet in Children with Autism: A Clinical Results of the Ophthalmic and Behavioral Manifestations

Yazarlar:

Öznur Özge Özcan | İbrahim Şahbaz | Emre Taşdöndüren | Mesut Karahan

Yayıncı:

İstanbul Gelisim University

Ana Başlıklar:

Klinik Beslenme

Dergi:

İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi Issue 21, pp.828-842

Belge Tipi:

Makale

Yayın Tarihi:

5/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001308775

pISSN:

2536-4499

Autism spectrum disorders

cognitive functions

corneal reflex

gluten-free casein-free diet

plusoptix a09

pupil sizeOtizm spektrum bozuklukları

bilişsel fonksiyonlar

kornea refleksi

glutensiz kazeinsiz diyet

plusoptix a09

pupil çapı

Sayı

Makale detayları

Yazarlar: Öznur Özge Özcan | İbrahim Şahbaz | Emre Taşdöndüren | Mesut Karahan

Yayıncı: İstanbul Gelisim University

Ana Başlıklar: Klinik Beslenme

Dergi: İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi Issue 21, pp.828-842

Belge Tipi: Makale

Yayın Tarihi: 5/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001308775

pISSN: 2536-4499

Sayı

Yazarlar:

Öznur Özge Özcan | İbrahim Şahbaz | Emre Taşdöndüren | Mesut Karahan

Yayıncı:

İstanbul Gelisim University

Ana Başlıklar:

Klinik Beslenme

Dergi:

İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi Issue 21, pp.828-842

Belge Tipi:

Makale

Yayın Tarihi:

5/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001308775

pISSN:

2536-4499