Evaluation of Genotoxicity Risk in Health Care Workers Exposed to Antineoplastic Drugs

Cagatay OLTULU; Tugce YESİL DEVECİOGLU; Melek AKİNCİ; Sevcan Gul AKGUN OLMEZ; Serra Vildan OBEİDİN; Ayfer Beceren

doi:https://doi.org/10.33808/clinexphealthsci.563988

Makale detayları

Evaluation of Genotoxicity Risk in Health Care Workers Exposed to Antineoplastic Drugs

Yazarlar:

Cagatay OLTULU | Tugce YESİL DEVECİOGLU | Melek AKİNCİ | Sevcan Gul AKGUN OLMEZ | Serra Vildan OBEİDİN | Ayfer Beceren

Yayıncı:

Marmara University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Clinical and Experimental Health Sciences 2019 Vol.9 Issue 2, pp.166-170

Belge Tipi:

Makale

Yayın Tarihi:

6/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000907093

Sıklık:

Aylık

eISSN:

2459-1459

DOI:

https://doi.org/10.33808/clinexphealthsci.563988

Özet:

 


Objective: DNA damage that can be caused by workplace exposure to antineoplastic drugs in health workers has been shown in many scientific studies. It is aimed to evaluate whether the risk of genotoxicity in health workers decreases after the regulations and measures taken by national and international health authorities in our work.

Methods: For this purpose, DNA damage was assessed by using alkaline comet technique in lymphocytes isolated from blood samples of health workers (n=29) who were involved in preparing and / or administering antineoplastic agent at Trakya University Health Research and Application Center and compared with the control group (n=30). Also, those who prepare and/or administer antineoplastic agents; (n=16) and manual (n=13) preparations.

Results: As a result of the evaluation, there was no statistically significant difference between health personnel and control group in preparing and / or administering antineoplastic agent (p>0,05, Mann-Whitney U) and there was no difference in the genotoxic risk between preparation forms. Furthermore, when the exposed control group was assessed for DNA damage as smokers and nonsmokers, there was no statistically significant difference in terms of DNA damage (p>0.05).

Conclusion: At the center where our samples were taken, the resulting measures resulted in the control of the risk of genotoxicity due to occupational exposure to antineoplastic agents.


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Makale detayları

Evaluation of Genotoxicity Risk in Health Care Workers Exposed to Antineoplastic Drugs

Yazarlar: Cagatay OLTULU | Tugce YESİL DEVECİOGLU | Melek AKİNCİ | Sevcan Gul AKGUN OLMEZ | Serra Vildan OBEİDİN | Ayfer Beceren

Yayıncı: Marmara University

Ana Başlıklar: Sağlık teşvikleri

Dergi: Clinical and Experimental Health Sciences 2019 Vol.9 Issue 2, pp.166-170

Belge Tipi: Makale

Yayın Tarihi: 6/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000907093

Sıklık: Aylık

eISSN: 2459-1459

DOI: https://doi.org/10.33808/clinexphealthsci.563988

Sayı

Yazarlar:

Cagatay OLTULU | Tugce YESİL DEVECİOGLU | Melek AKİNCİ | Sevcan Gul AKGUN OLMEZ | Serra Vildan OBEİDİN | Ayfer Beceren

Yayıncı:

Marmara University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Clinical and Experimental Health Sciences 2019 Vol.9 Issue 2, pp.166-170

Belge Tipi:

Makale

Yayın Tarihi:

6/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000907093

Sıklık:

Aylık

eISSN:

2459-1459

DOI:

https://doi.org/10.33808/clinexphealthsci.563988