The Role of p16, p21, p27, p53 and Ki-67 Expression in the Differential Diagnosis of Cutaneous Squamous Cell Carcinomas and Keratoacanthomas: An Immunohistochemical Study

Recep BEDİR; Hasan GÜÇER; İbrahim ŞEHİTOĞLU; Cüneyt YURDAKUL; Pelin BAĞCI; Pelin ÜSTÜNER

Makale detayları

The Role of p16, p21, p27, p53 and Ki-67 Expression in the Differential Diagnosis of Cutaneous Squamous Cell Carcinomas and Keratoacanthomas: An Immunohistochemical Study

Yazarlar:

Recep BEDİR | Hasan GÜÇER | İbrahim ŞEHİTOĞLU | Cüneyt YURDAKUL | Pelin BAĞCI | Pelin ÜSTÜNER

Yayıncı:

Trakya University

Dergi:

Balkan Medical Journal 2016 Vol.33 Issue 2, pp.121-127

Belge Tipi:

Makale

Yayın Tarihi:

2/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000759622

Sıklık:

İki Aylık

pISSN:

2146-3123

Özet:

 

Background: Distinguishing squamous cell carcinoma (SCC) from keratoacanthoma (KA) by histopathological features may not be sufficient for a differential diagnosis, as KAs may, in some cases, imitate well-differentiated SCCs.      Aims: In this study, we investigated whether the expression of the p16, p21, p27, p53 genes and a Ki-67 proliferation index are useful in distinguishing between these two tumors.      Study Design: Cross-sectional study.     Methods: Immunohistochemistry was used to investigate the expression of the p16, p21, p27, p53 genes and the Ki-67 proliferation index was investigated in well-differentiated SCC with KA-like features (n=40) and KA (n=30).     Results: The results of all of the examined markers, except for p27 (p16, p21, p53, and Ki-67) were found to be significantly different between the SCC and KA samples (p<0.05).      Conclusion: In well-differentiated SCC with KA-like features and KA cases where the differential diagnosis is difficult from a histopathological perspective, the use of p16, p21, p53 expression and a Ki-67 proliferation index can be useful for the differential diagnosis of SCCs and KAs.

Makale detayları

The Role of p16, p21, p27, p53 and Ki-67 Expression in the Differential Diagnosis of Cutaneous Squamous Cell Carcinomas and Keratoacanthomas: An Immunohistochemical Study

Yazarlar: Recep BEDİR | Hasan GÜÇER | İbrahim ŞEHİTOĞLU | Cüneyt YURDAKUL | Pelin BAĞCI | Pelin ÜSTÜNER

Yayıncı: Trakya University

Dergi: Balkan Medical Journal 2016 Vol.33 Issue 2, pp.121-127

Belge Tipi: Makale

Yayın Tarihi: 2/2016

Belge Dili: Türkçe

Document ID (Org No.): 2000759622

Sıklık: İki Aylık

pISSN: 2146-3123

Sayı

Yazarlar:

Recep BEDİR | Hasan GÜÇER | İbrahim ŞEHİTOĞLU | Cüneyt YURDAKUL | Pelin BAĞCI | Pelin ÜSTÜNER

Yayıncı:

Trakya University

Dergi:

Balkan Medical Journal 2016 Vol.33 Issue 2, pp.121-127

Belge Tipi:

Makale

Yayın Tarihi:

2/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000759622

Sıklık:

İki Aylık

pISSN:

2146-3123