Scintigraphic Assessment of Hepatobiliary Functions in Healthy Adult Dogs

Murat SARIERLER

Makale detayları

Scintigraphic Assessment of Hepatobiliary Functions in Healthy Adult Dogs

Yazarlar:

Murat SARIERLER

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Veterinary and Animal Sciences 2005 Vol.29 Issue 4, pp.1001-1006

Belge Tipi:

Makale

Yayın Tarihi:

3/2005

Belge Dili:

Türkçe

Document ID (Org No.):

2000768762

Sıklık:

İki Aylık

eISSN:

1303-6181

pISSN:

1300-0128

Anahtar kelimeler:

Özet:

 

Our objective was to investigate hepatobiliary functions in healthy dogs using 99mTc-mebrofenin hepatobiliary scintigraphy (HBS): 200 µCi/kg 99mTc-mebrofenin was injected intravenously into 12 healthy adult dogs. One-hour dynamic images and 2, 4 and 24 h static images were obtained. HBS was evaluated for 7 variables. Cardiac washout occurred within 3 min in all dogs. A photophenic area in the region of the gall bladder was seen in 3.03 ± 0.21 min. However, bile ducts were not identified as separate structures in any dogs. Mean Tmax of the liver was 7.95 ± 3.22 min. Initial gall bladder radioactivity was seen 13 ± 1.34 min after radiopharmaceutical injection. Mean hepatic washout time was 44 ± 3.15 min. Small intestinal radioactivity was not detected in the first 60 min, although it was observed within 2-4 h. However, it was not detected in 24 h late static images. In conclusion, 99mTc- mebrofenin HBS is a sensitive, specific and noninvasive diagnostic method with which to evaluate hepatocellulary functions, intrahepatic bile flow and gall bladder status in dogs. It is thought that the data obtained from this study may guide future research.

 

Our objective was to investigate hepatobiliary functions in healthy dogs using 99mTc-mebrofenin hepatobiliary scintigraphy (HBS): 200 µCi/kg 99mTc-mebrofenin was injected intravenously into 12 healthy adult dogs. One-hour dynamic images and 2, 4 and 24 h static images were obtained. HBS was evaluated for 7 variables. Cardiac washout occurred within 3 min in all dogs. A photophenic area in the region of the gall bladder was seen in 3.03 ± 0.21 min. However, bile ducts were not identified as separate structures in any dogs. Mean Tmax of the liver was 7.95 ± 3.22 min. Initial gall bladder radioactivity was seen 13 ± 1.34 min after radiopharmaceutical injection. Mean hepatic washout time was 44 ± 3.15 min. Small intestinal radioactivity was not detected in the first 60 min, although it was observed within 2-4 h. However, it was not detected in 24 h late static images. In conclusion, 99mTc- mebrofenin HBS is a sensitive, specific and noninvasive diagnostic method with which to evaluate hepatocellulary functions, intrahepatic bile flow and gall bladder status in dogs. It is thought that the data obtained from this study may guide future research.

Makale detayları

Scintigraphic Assessment of Hepatobiliary Functions in Healthy Adult Dogs

Yazarlar:

Murat SARIERLER

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Veterinary and Animal Sciences 2005 Vol.29 Issue 4, pp.1001-1006

Belge Tipi:

Makale

Yayın Tarihi:

3/2005

Belge Dili:

Türkçe

Document ID (Org No.):

2000768762

Sıklık:

İki Aylık

eISSN:

1303-6181

pISSN:

1300-0128

Scintigraphy

hepatobiliary

dog

99mTc-mebrofenin

Sayı

Makale detayları

Scintigraphic Assessment of Hepatobiliary Functions in Healthy Adult Dogs

Yazarlar: Murat SARIERLER

Yayıncı: TUBITAK

Dergi: Turkish Journal of Veterinary and Animal Sciences 2005 Vol.29 Issue 4, pp.1001-1006

Belge Tipi: Makale

Yayın Tarihi: 3/2005

Belge Dili: Türkçe

Document ID (Org No.): 2000768762

Sıklık: İki Aylık

eISSN: 1303-6181

pISSN: 1300-0128

Scintigraphy

hepatobiliary

dog

99mTc-mebrofenin

Sayı

Yazarlar:

Murat SARIERLER

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Veterinary and Animal Sciences 2005 Vol.29 Issue 4, pp.1001-1006

Belge Tipi:

Makale

Yayın Tarihi:

3/2005

Belge Dili:

Türkçe

Document ID (Org No.):

2000768762

Sıklık:

İki Aylık

eISSN:

1303-6181

pISSN:

1300-0128