Peroxisome Proliferator-activated Receptor-alpha (PPARA) and – Gamma (PPARG) Polymorphisms as Risk Factors for Dyslipidemia and MetS in Turkish Adults

Filiz Güçlü Geyik; Evrim Kömürcü-bayrak; Günay Can; Nihan Erginel-ünaltuna

Makale detayları

Peroxisome Proliferator-activated Receptor-alpha (PPARA) and – Gamma (PPARG) Polymorphisms as Risk Factors for Dyslipidemia and MetS in Turkish Adults

Yazarlar:

Filiz Güçlü Geyik | Evrim Kömürcü-bayrak | Günay Can | Nihan Erginel-ünaltuna

Yayıncı:

Istanbul University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Experimed Vol.13 Issue 3, pp.281-289

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001310806

pISSN:

2667-5846

Anahtar kelimeler:

Özet:

 Objective: Dyslipidemia and metabolic syndrome MetS are complex diseases affected by environmental factors such as lifestyle and genetic predisposition. The genes encoding peroxisome proliferator-activated receptor-gamma PPARG and alpha PPARA are crucial in the development of dyslipidemia and MetS. We aimed to investigate the relation of these genes with dyslipidemia and MetS in the Turkish adult population. Materials and Methods: The Turkish Adult Risk Factor TARF-TEKHARF cohort was randomly selected, and a cross-sectional analysis was performed. The PPARA rs1800206 CG genotypes were determined in a sample of 339 unrelated Turkish adults by a polymerase chain reaction-restriction fragment length polymorphism PCR-RFLP and 12 polyacrylamide gel electrophoresis PAGE methods. The PPARG rs1801282 CG genotypes were determined in a sample of 436 unrelated Turkish adults by a PCR-RFLP method. Results: Both single nucleotide polymorphisms SNPs minor alleles were related to a risk of dyslipidemia. Logistic regression analysis showed a significantly increased risk for dyslipidemia in G allele carriers of rs1800206 CG Odds Ratio OR 3.26; 95 CI 1.16-9.12, and in G risk allele carriers of rs1801282 OR 1.85; 95 CI 1.07-3.19, after adjustment for age, gender, lipid-lowering medication usage, physical activity and smoking status. Regarding MetS risk in the TARF study group, the G-allele of rs1800206 PPARA gene exhibited a significant OR of 3.75, after adjustment for gender, age, smoking status, and physical activity. Conclusion: The G alleles of the studied SNPs in the PPARA and PPARG genes are related to increased dyslipidemia risk. Furthermore, The G allele of the PPARA gene is related to increased MetS risk.

 Objective: Dyslipidemia and metabolic syndrome MetS are complex diseases affected by environmental factors such as lifestyle and genetic predisposition. The genes encoding peroxisome proliferator-activated receptor-gamma PPARG and alpha PPARA are crucial in the development of dyslipidemia and MetS. We aimed to investigate the relation of these genes with dyslipidemia and MetS in the Turkish adult population. Materials and Methods: The Turkish Adult Risk Factor TARF-TEKHARF cohort was randomly selected, and a cross-sectional analysis was performed. The PPARA rs1800206 CG genotypes were determined in a sample of 339 unrelated Turkish adults by a polymerase chain reaction-restriction fragment length polymorphism PCR-RFLP and 12 polyacrylamide gel electrophoresis PAGE methods. The PPARG rs1801282 CG genotypes were determined in a sample of 436 unrelated Turkish adults by a PCR-RFLP method. Results: Both single nucleotide polymorphisms SNPs minor alleles were related to a risk of dyslipidemia. Logistic regression analysis showed a significantly increased risk for dyslipidemia in G allele carriers of rs1800206 CG Odds Ratio OR 3.26; 95 CI 1.16-9.12, and in G risk allele carriers of rs1801282 OR 1.85; 95 CI 1.07-3.19, after adjustment for age, gender, lipid-lowering medication usage, physical activity and smoking status. Regarding MetS risk in the TARF study group, the G-allele of rs1800206 PPARA gene exhibited a significant OR of 3.75, after adjustment for gender, age, smoking status, and physical activity. Conclusion: The G alleles of the studied SNPs in the PPARA and PPARG genes are related to increased dyslipidemia risk. Furthermore, The G allele of the PPARA gene is related to increased MetS risk.

 Objective: Dyslipidemia and metabolic syndrome MetS are complex diseases affected by environmental factors such as lifestyle and genetic predisposition. The genes encoding peroxisome proliferator-activated receptor-gamma PPARG and alpha PPARA are crucial in the development of dyslipidemia and MetS. We aimed to investigate the relation of these genes with dyslipidemia and MetS in the Turkish adult population. Materials and Methods: The Turkish Adult Risk Factor TARF-TEKHARF cohort was randomly selected, and a cross-sectional analysis was performed. The PPARA rs1800206 CG genotypes were determined in a sample of 339 unrelated Turkish adults by a polymerase chain reaction-restriction fragment length polymorphism PCR-RFLP and 12 polyacrylamide gel electrophoresis PAGE methods. The PPARG rs1801282 CG genotypes were determined in a sample of 436 unrelated Turkish adults by a PCR-RFLP method. Results: Both single nucleotide polymorphisms SNPs minor alleles were related to a risk of dyslipidemia. Logistic regression analysis showed a significantly increased risk for dyslipidemia in G allele carriers of rs1800206 CG Odds Ratio OR 3.26; 95 CI 1.16-9.12, and in G risk allele carriers of rs1801282 OR 1.85; 95 CI 1.07-3.19, after adjustment for age, gender, lipid-lowering medication usage, physical activity and smoking status. Regarding MetS risk in the TARF study group, the G-allele of rs1800206 PPARA gene exhibited a significant OR of 3.75, after adjustment for gender, age, smoking status, and physical activity. Conclusion: The G alleles of the studied SNPs in the PPARA and PPARG genes are related to increased dyslipidemia risk. Furthermore, The G allele of the PPARA gene is related to increased MetS risk.

 Objective: Dyslipidemia and metabolic syndrome MetS are complex diseases affected by environmental factors such as lifestyle and genetic predisposition. The genes encoding peroxisome proliferator-activated receptor-gamma PPARG and alpha PPARA are crucial in the development of dyslipidemia and MetS. We aimed to investigate the relation of these genes with dyslipidemia and MetS in the Turkish adult population. Materials and Methods: The Turkish Adult Risk Factor TARF-TEKHARF cohort was randomly selected, and a cross-sectional analysis was performed. The PPARA rs1800206 CG genotypes were determined in a sample of 339 unrelated Turkish adults by a polymerase chain reaction-restriction fragment length polymorphism PCR-RFLP and 12 polyacrylamide gel electrophoresis PAGE methods. The PPARG rs1801282 CG genotypes were determined in a sample of 436 unrelated Turkish adults by a PCR-RFLP method. Results: Both single nucleotide polymorphisms SNPs minor alleles were related to a risk of dyslipidemia. Logistic regression analysis showed a significantly increased risk for dyslipidemia in G allele carriers of rs1800206 CG Odds Ratio OR 3.26; 95 CI 1.16-9.12, and in G risk allele carriers of rs1801282 OR 1.85; 95 CI 1.07-3.19, after adjustment for age, gender, lipid-lowering medication usage, physical activity and smoking status. Regarding MetS risk in the TARF study group, the G-allele of rs1800206 PPARA gene exhibited a significant OR of 3.75, after adjustment for gender, age, smoking status, and physical activity. Conclusion: The G alleles of the studied SNPs in the PPARA and PPARG genes are related to increased dyslipidemia risk. Furthermore, The G allele of the PPARA gene is related to increased MetS risk.

Makale detayları

Peroxisome Proliferator-activated Receptor-alpha (PPARA) and – Gamma (PPARG) Polymorphisms as Risk Factors for Dyslipidemia and MetS in Turkish Adults

Yazarlar:

Filiz Güçlü Geyik | Evrim Kömürcü-bayrak | Günay Can | Nihan Erginel-ünaltuna

Yayıncı:

Istanbul University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Experimed Vol.13 Issue 3, pp.281-289

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001310806

pISSN:

2667-5846

Dyslipidemia

metabolic syndrome

PPARA

PPARG and Turkish adults

Sayı

Makale detayları

Peroxisome Proliferator-activated Receptor-alpha (PPARA) and – Gamma (PPARG) Polymorphisms as Risk Factors for Dyslipidemia and MetS in Turkish Adults

Yazarlar: Filiz Güçlü Geyik | Evrim Kömürcü-bayrak | Günay Can | Nihan Erginel-ünaltuna

Yayıncı: Istanbul University

Ana Başlıklar: Clinical Sciences (Other)

Dergi: Experimed Vol.13 Issue 3, pp.281-289

Belge Tipi: Makale

Yayın Tarihi: 12/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001310806

pISSN: 2667-5846

Dyslipidemia

metabolic syndrome

PPARA

PPARG and Turkish adults

Sayı

Yazarlar:

Filiz Güçlü Geyik | Evrim Kömürcü-bayrak | Günay Can | Nihan Erginel-ünaltuna

Yayıncı:

Istanbul University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Experimed Vol.13 Issue 3, pp.281-289

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001310806

pISSN:

2667-5846