Synthesis of Dihydrobenzofuranone Derivatives with Biotechnological Methods

Zerrin Zerenler Çalışkan; Ebru Nur Ay

doi:https://doi.org/10.18596/jotcsa.448551

Makale detayları

Synthesis of Dihydrobenzofuranone Derivatives with Biotechnological Methods

Yazarlar:

Zerrin Zerenler Çalışkan | Ebru Nur Ay

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Kimya mühendisliği

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry 2018 Vol.5 Issue 3, pp.1221-1232

Belge Tipi:

Makale

Yayın Tarihi:

8/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000503019

Sıklık:

Üç Aylık

eISSN:

2149-0120

DOI:

https://doi.org/10.18596/jotcsa.448551

Özet:

 

Benzofuranone 
derivatives are important structural units in many biologically active
compounds thus, synthesis of these types of compounds in optically pure form
found increased interest in pharmaceutical chemistry. In this study, the
enantioselective synthesis of 4,5,6,7-tetrahydro-6-phenyl-4-oxo-benzofuranone-5-yl
acetate (3) and 4,5,6,7-tetrahydro-6-
phenyl-4-oxo-benzofuranone-5-yl hydroxy derivative (4) was carried out for the first time,  by enzyme-mediated hydrolysis reactions with
high enantiomeric excesses. Several lipases were used for the kinetic
resolution in different pH values and different solvent systems of racemic 4,5,6,7-tetrahydro-6-phenyl-4-oxo-benzofuranone-5-yl
acetate (rac-3) in which the lipases
from HPL, PPL,  RNL and PCL displayed
high enentioselectivity towards 4,5,6,7-tetrahydro-6- phenyl-4-oxo-benzofuranone-5-yl
hydroxy derivative (4)  at pH=7. .

Makale detayları

Synthesis of Dihydrobenzofuranone Derivatives with Biotechnological Methods

Yazarlar: Zerrin Zerenler Çalışkan | Ebru Nur Ay

Yayıncı: Turkish Chemical Society

Ana Başlıklar: Kimya mühendisliği

Dergi: Journal of the Turkish Chemical Society Section A: Chemistry 2018 Vol.5 Issue 3, pp.1221-1232

Belge Tipi: Makale

Yayın Tarihi: 8/2018

Belge Dili: İngilizce

Document ID (Org No.): 2000503019

Sıklık: Üç Aylık

eISSN: 2149-0120

DOI: https://doi.org/10.18596/jotcsa.448551

Sayı

Yazarlar:

Zerrin Zerenler Çalışkan | Ebru Nur Ay

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Kimya mühendisliği

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry 2018 Vol.5 Issue 3, pp.1221-1232

Belge Tipi:

Makale

Yayın Tarihi:

8/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000503019

Sıklık:

Üç Aylık

eISSN:

2149-0120

DOI:

https://doi.org/10.18596/jotcsa.448551