Acinetobacter baumannii Strains Isolated from Various Clinical Samples of  Patients Admitted to the Intensive Care Unit and Four-Year Resistance Profiles

Arzu Kayış; Zerife Orhan; Burak Küçük; Adem Doğaner; Murat Aral

Makale detayları

Acinetobacter baumannii Strains Isolated from Various Clinical Samples of Patients Admitted to the Intensive Care Unit and Four-Year Resistance Profiles

Yazarlar:

Arzu Kayış | Zerife Orhan | Burak Küçük | Adem Doğaner | Murat Aral

Yayıncı:

Harran University

Ana Başlıklar:

Tıbbi Bakteriyoloji

Dergi:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.20 Issue 3, pp.560-565

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001298510

pISSN:

1304-9623

Anahtar kelimeler:

Özet:

 Background: Intensive care units are the most frequently affected areas by infections caused by Acinetobacter baumannii. Due to its rapid development of antimicrobial resistance, causes serious therapeutic problems. The aim of this study is to determine antibiotic susceptibilities of A. baumannii strains isolated from intensive care units over a four-year period. Materials and Methods: A. baumannii strains isolated from various samples sent from intensive care units to the medical microbiology laboratory between January 2018 and December 2021 were included in the study. Bacterial identification and antibiotic susceptibility tests were performed using standard microbiological met-hods and automated systems. Antibiotic resistance data from 2018 to 2021 were compared using the Chi-square and Fishers Exact test, and p0.05 was considered statistically significant. Results: A total of 1900 A. baumannii strains were included in the study. These strains were most commonly isolated from tracheal aspirate culture samples 1011; 53. Among the intensive care units, it was determined that it was most frequently isolated from the Anesthesiology and Reanimation intensive care unit 697; 37. When comparing the years 2018 and 2021, an increase in antibiotic resistance was observed in A. baumannii. The most significant resistance increase was found in amikacin, trimethoprimsulfamethoxazole, and levof-loxacin p0.001. Conclusions: Our study revealed high antibiotic resistance among A. baumannii strains. Regular monitoring and reporting of antibiotic susceptibility results will enable physicians to establish antibiotic usage policies and take infection control measures.

 Background: Intensive care units are the most frequently affected areas by infections caused by Acinetobacter baumannii. Due to its rapid development of antimicrobial resistance, causes serious therapeutic problems. The aim of this study is to determine antibiotic susceptibilities of A. baumannii strains isolated from intensive care units over a four-year period. Materials and Methods: A. baumannii strains isolated from various samples sent from intensive care units to the medical microbiology laboratory between January 2018 and December 2021 were included in the study. Bacterial identification and antibiotic susceptibility tests were performed using standard microbiological met-hods and automated systems. Antibiotic resistance data from 2018 to 2021 were compared using the Chi-square and Fishers Exact test, and p0.05 was considered statistically significant. Results: A total of 1900 A. baumannii strains were included in the study. These strains were most commonly isolated from tracheal aspirate culture samples 1011; 53. Among the intensive care units, it was determined that it was most frequently isolated from the Anesthesiology and Reanimation intensive care unit 697; 37. When comparing the years 2018 and 2021, an increase in antibiotic resistance was observed in A. baumannii. The most significant resistance increase was found in amikacin, trimethoprimsulfamethoxazole, and levof-loxacin p0.001. Conclusions: Our study revealed high antibiotic resistance among A. baumannii strains. Regular monitoring and reporting of antibiotic susceptibility results will enable physicians to establish antibiotic usage policies and take infection control measures.

 Background: Intensive care units are the most frequently affected areas by infections caused by Acinetobacter baumannii. Due to its rapid development of antimicrobial resistance, causes serious therapeutic problems. The aim of this study is to determine antibiotic susceptibilities of A. baumannii strains isolated from intensive care units over a four-year period. Materials and Methods: A. baumannii strains isolated from various samples sent from intensive care units to the medical microbiology laboratory between January 2018 and December 2021 were included in the study. Bacterial identification and antibiotic susceptibility tests were performed using standard microbiological met-hods and automated systems. Antibiotic resistance data from 2018 to 2021 were compared using the Chi-square and Fishers Exact test, and p0.05 was considered statistically significant. Results: A total of 1900 A. baumannii strains were included in the study. These strains were most commonly isolated from tracheal aspirate culture samples 1011; 53. Among the intensive care units, it was determined that it was most frequently isolated from the Anesthesiology and Reanimation intensive care unit 697; 37. When comparing the years 2018 and 2021, an increase in antibiotic resistance was observed in A. baumannii. The most significant resistance increase was found in amikacin, trimethoprimsulfamethoxazole, and levof-loxacin p0.001. Conclusions: Our study revealed high antibiotic resistance among A. baumannii strains. Regular monitoring and reporting of antibiotic susceptibility results will enable physicians to establish antibiotic usage policies and take infection control measures.

 Amaç: Yoğun bakım üniteleri Acinetobacter baumanniinin neden olduğu enfeksiyonlardan en sık etkilenen alanlardır. Hızlı bir şekilde antimikrobiyal direnç geliştirme eğilimi nedeniyle ciddi terapötik sorunlara yol açmaktadır. Bu çalışmanın amacı yoğun bakım ünitelerinden izole edilen Acinetobacter baumannii suşlarının dört yıllık süreçteki antibiyotik duyarlılıklarını belirlemektir. Materyal ve Metod: Ocak 2018Aralık 2021 yılları arasında yoğun bakım ünitelerinden tıbbi mikrobiyoloji laboratuvarına gönderilen çeşitli örneklerden izole edilen Acinetobacter baumannii suşları çalışmaya dahil edilmiştir. Bakteri tanımlanması ve antibiyotik duyarlılık testleri standart mikrobiyolojik yöntemler ve otomatize sistemler kullanılarak yapılmıştır. Antibiyotik direncinde 2018 ile 2021 yılı verileri Ki-Kare ve Fisher Exact test ile karşılaştırılmış ve p0.05 anlamlı olarak kabul edilmiştir. Bulgular: Toplam 1900 Acinetobacter baumannii suşu çalışmaya dahil edilmiştir. Bu suşlar en sık trakeal aspirat kültür örneklerinden 1011; 53 izole edilmiştir. Yoğun bakım arasında da en sık Anesteziyoloji ve Reanimasyon yoğun bakım ünitesinden 697; 37 izole edildiği saptanmıştır. 2018 yılı ile 2021 yılı karşılaştırıldığında Acinetobacter baumanniide antibiyotiklere karşı direnç oranının arttığı görülmüştür. İstatistiksel olarak en anlamlı direnç artışı amikasin, trimetoprim sulfametoksazol ve levofloksasinde saptanmıştır p0.001. Sonuç: Çalışmamızda Acinetobacter baumannii suşlarında antibiyotiklere direncin yüksek olduğu görülmektedir. Antibiyotik duyarlılık sonuçlarının düzenli olarak takip edilmesi ve raporlanması, hekimlerin antibiyotik kullanım politikalarını belirlemelerine ve enfeksiyon kontrol önlemleri almalarına olanak tanıyacaktır.

Makale detayları

Acinetobacter baumannii Strains Isolated from Various Clinical Samples of Patients Admitted to the Intensive Care Unit and Four-Year Resistance Profiles

Yazarlar:

Arzu Kayış | Zerife Orhan | Burak Küçük | Adem Doğaner | Murat Aral

Yayıncı:

Harran University

Ana Başlıklar:

Tıbbi Bakteriyoloji

Dergi:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.20 Issue 3, pp.560-565

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001298510

pISSN:

1304-9623

Acinetobacter baumannii

Yoğun Bakım Üniteleri

Antibiyotik Direnci

Sayı

Makale detayları

Acinetobacter baumannii Strains Isolated from Various Clinical Samples of Patients Admitted to the Intensive Care Unit and Four-Year Resistance Profiles

Yazarlar: Arzu Kayış | Zerife Orhan | Burak Küçük | Adem Doğaner | Murat Aral

Yayıncı: Harran University

Ana Başlıklar: Tıbbi Bakteriyoloji

Dergi: Harran Üniversitesi Tıp Fakültesi Dergisi Vol.20 Issue 3, pp.560-565

Belge Tipi: Makale

Yayın Tarihi: 12/2023

Belge Dili: Türkçe

Document ID (Org No.): 2001298510

pISSN: 1304-9623

Acinetobacter baumannii

Yoğun Bakım Üniteleri

Antibiyotik Direnci

Sayı

Yazarlar:

Arzu Kayış | Zerife Orhan | Burak Küçük | Adem Doğaner | Murat Aral

Yayıncı:

Harran University

Ana Başlıklar:

Tıbbi Bakteriyoloji

Dergi:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.20 Issue 3, pp.560-565

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001298510

pISSN:

1304-9623