Effect of surfactant types and concentrations on levofloxacin-loaded PLGA microparticles for pulmonary delivery – An in vitro study

Burcu Devrim Gökberk; Müjde Eryilmaz; Asuman Bozkır

Makale detayları

Effect of surfactant types and concentrations on levofloxacin-loaded PLGA microparticles for pulmonary delivery – An in vitro study

Yazarlar:

Burcu Devrim Gökberk | Müjde Eryilmaz | Asuman Bozkır

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Microbiology | Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 5, pp.1156-1176

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347537

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 The aim of this work was to develop levofloxacin-loaded drug delivery systems for pulmonary administration. Levofloxacin-loaded PLGA microparticles were prepared by water-in-oil-in-oil woo emulsion solvent evaporation method using PLGA as the polymer. Then, the effect of surfactant type and concentration in the inner aqueous phase or outer oily phase on the physicochemical characteristics of the microparticles were investigated. PLGA-based microparticles have spherical shape with a particle size of about 5 μm, which is suitable for pulmonary delivery. Very high values for encapsulation efficiency up to 90 were obtained. The in vitro release of levofloxacin from the PLGA microparticles was sustained for 24 hours. The aerodynamic diameter and fine particle fraction were 5.44  0.19 μm and 50.99  2.89, respectively. Antimicrobial efficacy studies showed that levofloxacin-loaded PLGA microparticles inhibited bacterial growth. These results suggest that levofloxacin-loaded PLGA microparticles may be suitable for pulmonary administration.

 The aim of this work was to develop levofloxacin-loaded drug delivery systems for pulmonary administration. Levofloxacin-loaded PLGA microparticles were prepared by water-in-oil-in-oil woo emulsion solvent evaporation method using PLGA as the polymer. Then, the effect of surfactant type and concentration in the inner aqueous phase or outer oily phase on the physicochemical characteristics of the microparticles were investigated. PLGA-based microparticles have spherical shape with a particle size of about 5 μm, which is suitable for pulmonary delivery. Very high values for encapsulation efficiency up to 90 were obtained. The in vitro release of levofloxacin from the PLGA microparticles was sustained for 24 hours. The aerodynamic diameter and fine particle fraction were 5.44  0.19 μm and 50.99  2.89, respectively. Antimicrobial efficacy studies showed that levofloxacin-loaded PLGA microparticles inhibited bacterial growth. These results suggest that levofloxacin-loaded PLGA microparticles may be suitable for pulmonary administration.

 The aim of this work was to develop levofloxacin-loaded drug delivery systems for pulmonary administration. Levofloxacin-loaded PLGA microparticles were prepared by water-in-oil-in-oil woo emulsion solvent evaporation method using PLGA as the polymer. Then, the effect of surfactant type and concentration in the inner aqueous phase or outer oily phase on the physicochemical characteristics of the microparticles were investigated. PLGA-based microparticles have spherical shape with a particle size of about 5 μm, which is suitable for pulmonary delivery. Very high values for encapsulation efficiency up to 90 were obtained. The in vitro release of levofloxacin from the PLGA microparticles was sustained for 24 hours. The aerodynamic diameter and fine particle fraction were 5.44  0.19 μm and 50.99  2.89, respectively. Antimicrobial efficacy studies showed that levofloxacin-loaded PLGA microparticles inhibited bacterial growth. These results suggest that levofloxacin-loaded PLGA microparticles may be suitable for pulmonary administration.

 The aim of this work was to develop levofloxacin-loaded drug delivery systems for pulmonary administration. Levofloxacin-loaded PLGA microparticles were prepared by water-in-oil-in-oil woo emulsion solvent evaporation method using PLGA as the polymer. Then, the effect of surfactant type and concentration in the inner aqueous phase or outer oily phase on the physicochemical characteristics of the microparticles were investigated. PLGA-based microparticles have spherical shape with a particle size of about 5 μm, which is suitable for pulmonary delivery. Very high values for encapsulation efficiency up to 90 were obtained. The in vitro release of levofloxacin from the PLGA microparticles was sustained for 24 hours. The aerodynamic diameter and fine particle fraction were 5.44  0.19 μm and 50.99  2.89, respectively. Antimicrobial efficacy studies showed that levofloxacin-loaded PLGA microparticles inhibited bacterial growth. These results suggest that levofloxacin-loaded PLGA microparticles may be suitable for pulmonary administration.

Makale detayları

Effect of surfactant types and concentrations on levofloxacin-loaded PLGA microparticles for pulmonary delivery – An in vitro study

Yazarlar:

Burcu Devrim Gökberk | Müjde Eryilmaz | Asuman Bozkır

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Microbiology | Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 5, pp.1156-1176

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347537

pISSN:

2630-6344

Levofloxacin

drug delivery systems

w/o/o

surfactant type; PLGA

pulmonary delivery

Sayı

Makale detayları

Effect of surfactant types and concentrations on levofloxacin-loaded PLGA microparticles for pulmonary delivery – An in vitro study

Yazarlar: Burcu Devrim Gökberk | Müjde Eryilmaz | Asuman Bozkır

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Microbiology | Pharmaceutical Delivery Technologies

Dergi: Journal of Research in Pharmacy Vol.26 Issue 5, pp.1156-1176

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347537

pISSN: 2630-6344

Levofloxacin

drug delivery systems

w/o/o

surfactant type; PLGA

pulmonary delivery

Sayı

Yazarlar:

Burcu Devrim Gökberk | Müjde Eryilmaz | Asuman Bozkır

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Microbiology | Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 5, pp.1156-1176

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347537

pISSN:

2630-6344