Synthesis, antibacterial and antioxidant activity of novel     12-(N-arylmethaniminyl)indolo[1,2-c]quinazolines

N.A.

Makale detayları

Synthesis, antibacterial and antioxidant activity of novel 12-(N-arylmethaniminyl)indolo[1,2-c]quinazolines

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Basic Pharmacology

Dergi:

Journal of Research in Pharmacy Vol.23 Issue 3, pp.584-595

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347206

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 The objective of the present research was to synthesize 12-N-arylmethaniminylindolo 1,2-cquinazoline derivatives 4a1-4a11 and further characterize in terms of 1H NMR, 13C NMR, FTIR and mass spectrophotometry. Evaluation of their antibacterial and antioxidant activity was also carried out. Most compounds have shown a good antioxidant activity in all the concentrations but compounds 4a7, 4a8 and 4a11 were found to be most potent antioxidants in comparison to others with an IC50 value of 18.78  1.86 μgml, 16.84  2.60 μgml and 18.64  2.40 μgml, respectively DPPH method and 18.83  2.89 μgml, 16.61  3.00 μgml  16.8  3.34 μgml, respectively H2O2 method. Antibacterial activity was done against B. subtilis and E. coli with the help of agar well diffusion method and it showed that all the derivatives in the series are having good antibacterial activity but compounds 4a9 and 4a11 were found to be most promising antibacterial agents. It was concluded that the compounds containing substituted anilines 4-nitro, 4-fluoro, 4-bromo and 4-chloro-2-nitro on the methaniminyl group of 12th position of indoloquinazoline moiety have good antioxidant and antibacterial activities.

 The objective of the present research was to synthesize 12-N-arylmethaniminylindolo 1,2-cquinazoline derivatives 4a1-4a11 and further characterize in terms of 1H NMR, 13C NMR, FTIR and mass spectrophotometry. Evaluation of their antibacterial and antioxidant activity was also carried out. Most compounds have shown a good antioxidant activity in all the concentrations but compounds 4a7, 4a8 and 4a11 were found to be most potent antioxidants in comparison to others with an IC50 value of 18.78  1.86 μgml, 16.84  2.60 μgml and 18.64  2.40 μgml, respectively DPPH method and 18.83  2.89 μgml, 16.61  3.00 μgml  16.8  3.34 μgml, respectively H2O2 method. Antibacterial activity was done against B. subtilis and E. coli with the help of agar well diffusion method and it showed that all the derivatives in the series are having good antibacterial activity but compounds 4a9 and 4a11 were found to be most promising antibacterial agents. It was concluded that the compounds containing substituted anilines 4-nitro, 4-fluoro, 4-bromo and 4-chloro-2-nitro on the methaniminyl group of 12th position of indoloquinazoline moiety have good antioxidant and antibacterial activities.

 The objective of the present research was to synthesize 12-N-arylmethaniminylindolo 1,2-cquinazoline derivatives 4a1-4a11 and further characterize in terms of 1H NMR, 13C NMR, FTIR and mass spectrophotometry. Evaluation of their antibacterial and antioxidant activity was also carried out. Most compounds have shown a good antioxidant activity in all the concentrations but compounds 4a7, 4a8 and 4a11 were found to be most potent antioxidants in comparison to others with an IC50 value of 18.78  1.86 μgml, 16.84  2.60 μgml and 18.64  2.40 μgml, respectively DPPH method and 18.83  2.89 μgml, 16.61  3.00 μgml  16.8  3.34 μgml, respectively H2O2 method. Antibacterial activity was done against B. subtilis and E. coli with the help of agar well diffusion method and it showed that all the derivatives in the series are having good antibacterial activity but compounds 4a9 and 4a11 were found to be most promising antibacterial agents. It was concluded that the compounds containing substituted anilines 4-nitro, 4-fluoro, 4-bromo and 4-chloro-2-nitro on the methaniminyl group of 12th position of indoloquinazoline moiety have good antioxidant and antibacterial activities.

 The objective of the present research was to synthesize 12-N-arylmethaniminylindolo 1,2-cquinazoline derivatives 4a1-4a11 and further characterize in terms of 1H NMR, 13C NMR, FTIR and mass spectrophotometry. Evaluation of their antibacterial and antioxidant activity was also carried out. Most compounds have shown a good antioxidant activity in all the concentrations but compounds 4a7, 4a8 and 4a11 were found to be most potent antioxidants in comparison to others with an IC50 value of 18.78  1.86 μgml, 16.84  2.60 μgml and 18.64  2.40 μgml, respectively DPPH method and 18.83  2.89 μgml, 16.61  3.00 μgml  16.8  3.34 μgml, respectively H2O2 method. Antibacterial activity was done against B. subtilis and E. coli with the help of agar well diffusion method and it showed that all the derivatives in the series are having good antibacterial activity but compounds 4a9 and 4a11 were found to be most promising antibacterial agents. It was concluded that the compounds containing substituted anilines 4-nitro, 4-fluoro, 4-bromo and 4-chloro-2-nitro on the methaniminyl group of 12th position of indoloquinazoline moiety have good antioxidant and antibacterial activities.

Makale detayları

Synthesis, antibacterial and antioxidant activity of novel 12-(N-arylmethaniminyl)indolo[1,2-c]quinazolines

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Basic Pharmacology

Dergi: Journal of Research in Pharmacy Vol.23 Issue 3, pp.584-595

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347206

pISSN: 2630-6344

Synthesis

indoloquinazoline

antioxidant

antibacterial

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Basic Pharmacology

Dergi:

Journal of Research in Pharmacy Vol.23 Issue 3, pp.584-595

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347206

pISSN:

2630-6344