Investigation of the Relationship of CRP/Albumin Ratio with Clinical Parameters, Prognosis and Physiotherapy in Amyotrophic Lateral Sclerosis CRP/Albumin Ratio in Amyotrophic Lateral Sclerosis

Gülseren Demir Karakılıç; Güven Arslan

Makale detayları

Investigation of the Relationship of CRP/Albumin Ratio with Clinical Parameters, Prognosis and Physiotherapy in Amyotrophic Lateral Sclerosis CRP/Albumin Ratio in Amyotrophic Lateral Sclerosis

Yazarlar:

Gülseren Demir Karakılıç | Güven Arslan

Yayıncı:

İstanbul Gelisim University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi Issue 25, pp.40-52

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346548

pISSN:

2536-4499

Anahtar kelimeler:

Özet:

 Aim: The aim of this study was to investigate relationship of onset CAR value with clinical parameters, post treatment functional capacity and physiotherapy effectiveness in patients with Amyotrophic Lateral Sclerosis ALS. Method: Ethical approval was obtained for this study on June 16, 2023, with number E. Kurul-2023-21751. This retrospective study was undertaken between January 2021 and January 2024. Forty-five patients whose blood test results, Revised Amyotrophic Lateral Sclerosis Functional Rating Scale ALSFRS-R score records and disease-related clinical findings were accessed through electronic patient report were included in study among 57 patients diagnosed with ALS. Forty-five healthy people of similar age and gender who attended check-up clinic without any complaints were included in study as a control group. Results: A total of 90 people, 45 patients with ALS and 45 healthy people as control group were included in study. The femalemale ratio and mean age of both groups were similar and there was no statistical difference. The mean CAR of patients with ALS was 1.920.14, while mean CAR of control group 0.820,15 and there was no significant difference between groups in terms of mean CAR p: 0.2. WBC and Neutrophil were significantly higher in ALS group according to control group p:0.017, p:0.038. CAR was not found to correlate with clinical parameters of ALS and number of physiotherapy sessions received. Functional ambulation Scale scores were found to be higher as number of physical therapy sessions increased. Conclusion: This study is first to evaluate CAR in ALS patients. CAR measured at time of diagnosis of ALS disease was not significantly higher than control group, and we could not find a relationship between CAR and post treatment functional scores. However, CAR may be an important parameter, especially in evaluating malnutrition and chronic inflammation when disease progresses and complications develop.

 Aim: The aim of this study was to investigate relationship of onset CAR value with clinical parameters, post treatment functional capacity and physiotherapy effectiveness in patients with Amyotrophic Lateral Sclerosis ALS. Method: Ethical approval was obtained for this study on June 16, 2023, with number E. Kurul-2023-21751. This retrospective study was undertaken between January 2021 and January 2024. Forty-five patients whose blood test results, Revised Amyotrophic Lateral Sclerosis Functional Rating Scale ALSFRS-R score records and disease-related clinical findings were accessed through electronic patient report were included in study among 57 patients diagnosed with ALS. Forty-five healthy people of similar age and gender who attended check-up clinic without any complaints were included in study as a control group. Results: A total of 90 people, 45 patients with ALS and 45 healthy people as control group were included in study. The femalemale ratio and mean age of both groups were similar and there was no statistical difference. The mean CAR of patients with ALS was 1.920.14, while mean CAR of control group 0.820,15 and there was no significant difference between groups in terms of mean CAR p: 0.2. WBC and Neutrophil were significantly higher in ALS group according to control group p:0.017, p:0.038. CAR was not found to correlate with clinical parameters of ALS and number of physiotherapy sessions received. Functional ambulation Scale scores were found to be higher as number of physical therapy sessions increased. Conclusion: This study is first to evaluate CAR in ALS patients. CAR measured at time of diagnosis of ALS disease was not significantly higher than control group, and we could not find a relationship between CAR and post treatment functional scores. However, CAR may be an important parameter, especially in evaluating malnutrition and chronic inflammation when disease progresses and complications develop.

 Aim: The aim of this study was to investigate relationship of onset CAR value with clinical parameters, post treatment functional capacity and physiotherapy effectiveness in patients with Amyotrophic Lateral Sclerosis ALS. Method: Ethical approval was obtained for this study on June 16, 2023, with number E. Kurul-2023-21751. This retrospective study was undertaken between January 2021 and January 2024. Forty-five patients whose blood test results, Revised Amyotrophic Lateral Sclerosis Functional Rating Scale ALSFRS-R score records and disease-related clinical findings were accessed through electronic patient report were included in study among 57 patients diagnosed with ALS. Forty-five healthy people of similar age and gender who attended check-up clinic without any complaints were included in study as a control group. Results: A total of 90 people, 45 patients with ALS and 45 healthy people as control group were included in study. The femalemale ratio and mean age of both groups were similar and there was no statistical difference. The mean CAR of patients with ALS was 1.920.14, while mean CAR of control group 0.820,15 and there was no significant difference between groups in terms of mean CAR p: 0.2. WBC and Neutrophil were significantly higher in ALS group according to control group p:0.017, p:0.038. CAR was not found to correlate with clinical parameters of ALS and number of physiotherapy sessions received. Functional ambulation Scale scores were found to be higher as number of physical therapy sessions increased. Conclusion: This study is first to evaluate CAR in ALS patients. CAR measured at time of diagnosis of ALS disease was not significantly higher than control group, and we could not find a relationship between CAR and post treatment functional scores. However, CAR may be an important parameter, especially in evaluating malnutrition and chronic inflammation when disease progresses and complications develop.

 Amaç: Bu çalışmanın amacı, Amyotrofik Lateral Sklerozlu ALS hastalarda başlangıç CRPalbümin oranı CAR değerinin klinik parametreler, tedavi sonrası fonksiyonel kapasite ve fizyoterapi etkinliği ile ilişkisini araştırmaktır. Yöntem: Bu çalışma için 16 Haziran 2023 tarihinde E. Kurul-2023-21751 numarasıyla etik onay alındı. Bu retrospektif çalışma Ocak 2021 ile Ocak 2024 tarihleri arasında gerçekleştirildi. ALS tanısı almış 57 hasta arasından kan testi sonuçları, Revize Amyotrofik Lateral Skleroz Fonksiyonel Değerlendirme Ölçeği ALSFRS-R skor kayıtları ve hastalıkla ilişkili klinik bulguları elektronik hasta raporu aracılığıyla erişilen 45 hasta çalışmaya dahil edildi. Herhangi bir şikayeti olmadan Check-up polikliniğine başvuran benzer yaş ve cinsiyetteki 45 sağlıklı kişi kontrol grubu olarak çalışmaya dahil edildi. Bulgular: Çalışmaya 45 ALS tanılı hasta ve 45 sağlıklı kişi kontrol grubu olmak üzere toplam 90 kişi dahil edildi. Her iki grubun kadınerkek oranı ve yaş ortalamaları benzerdi ve istatistiksel olarak fark yoktu. ALSli hastaların ortalama CARı 1,920,14 iken, kontrol grubunun ortalama CARı 0,820,15 idi ve ortalama CAR açısından gruplar arasında anlamlı bir fark yoktu p: 0,2. Beyaz Küre Hücresi WBC ve Nötrofil, ALS grubunda kontrol grubuna göre anlamlı olarak daha yüksekti p:0,017, p:0,038. CARın ALSnin klinik parametreleri ve alınan fizyoterapi seansı sayısı ile ilişkili olmadığı bulundu. Fonksiyonel ambulasyon Ölçeği puanlarının, fizyoterapi seansı sayısı arttıkça daha yüksek olduğu bulundu. Sonuç: Bu çalışma, ALSli hastalarda CARı değerlendirmek için ilk çalışmadır. ALS hastalığının tanısı sırasında ölçülen CAR, kontrol grubundan anlamlı olarak daha yüksek değildi ve CAR ile tedavi sonrası fonksiyonel puanlar arasında bir ilişki bulamadık. Ancak, CAR, özellikle hastalık ilerlediğinde ve komplikasyonlar geliştiğinde yetersiz beslenmeyi ve kronik inflamasyonu değerlendirmede önemli bir parametre olabilir.

Makale detayları

Investigation of the Relationship of CRP/Albumin Ratio with Clinical Parameters, Prognosis and Physiotherapy in Amyotrophic Lateral Sclerosis CRP/Albumin Ratio in Amyotrophic Lateral Sclerosis

Yazarlar:

Gülseren Demir Karakılıç | Güven Arslan

Yayıncı:

İstanbul Gelisim University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi Issue 25, pp.40-52

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346548

pISSN:

2536-4499

Amyotrophic Lateral Sclerosis

CRP/Albumin ratio

Amyotrophic Lateral Sclerosis Functional Rating Scale

physiotherapy effectivenessAmyotrofik Lateral Skleroz

CRP/Albümin oranı

Amyotrofik Lateral Skleroz Fonksiyonel Derecelendirme Ölçeği

fizyoterapi etkinliği

Sayı

Makale detayları

Yazarlar: Gülseren Demir Karakılıç | Güven Arslan

Yayıncı: İstanbul Gelisim University

Ana Başlıklar: Klinik Tıp Bilimleri (Diğer)

Dergi: İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi Issue 25, pp.40-52

Belge Tipi: Makale

Yayın Tarihi: 4/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346548

pISSN: 2536-4499

Sayı

Yazarlar:

Gülseren Demir Karakılıç | Güven Arslan

Yayıncı:

İstanbul Gelisim University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi Issue 25, pp.40-52

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346548

pISSN:

2536-4499