Effects of aluminum, copper, and titanium nanoparticles on  some blood parameters in Wistar rats

ESİN GÜLNAZ CANLI; MUSTAFA CANLI

Makale detayları

Effects of aluminum, copper, and titanium nanoparticles on some blood parameters in Wistar rats

Yazarlar:

ESİN GÜLNAZ CANLI | MUSTAFA CANLI

Yayıncı:

TUBITAK

Ana Başlıklar:

Zooloji bilimleri/Hayvanlar

Dergi:

Turkish Journal of Zoology 2017 Vol.41 Issue 2, pp.259-266

Belge Tipi:

Makale

Yayın Tarihi:

3/2017

Belge Dili:

İngilizce

Document ID (Org No.):

2000774117

Sıklık:

İki Aylık

eISSN:

1303-6114

pISSN:

1300-0179

Özet:

 

In this study, Al2O3, CuO, and TiO2 nanoparticles (NPs) were individually administered to 60 mature female rats via oral  gavage (0, 0.5, 5, and 50 mg/kg b.w. per day) for 14 days and then responses of ATPases in the erythrocytes, total oxidant status (TOS),  total antioxidant status (TAS), and liver enzyme (alkaline phosphatase, ALP; alanine transaminase, ALT; aspartate transaminase, AST)  levels in the serum were determined. There were sharp decreases in Na,K-ATPase activity in the erythrocytes following NP exposures.  All doses of CuO caused significant (P < 0.05) inhibitions in Na,K-ATPase activity (up to 94%), while only higher doses of Al2O3 and  TiO2 inhibited (76%-80%) the activity of Na,K-ATPase. Oppositely, the activities of Ca-ATPase (up to 274%) and Mg-ATPase (up to  290%) increased significantly following TiO2 exposures. TOS levels significantly increased following Al2O3 (167%) and CuO (240%)  exposures, though TAS levels did not change significantly in any of the exposure groups. The levels of ALP, AST, and ALT increased  following NP administrations. Ti-NP increased the levels of all liver enzymes in the serum (up to 84%), while Al-NP (58%) and Cu-  NP (43%) increased only ALP levels. The present study demonstrated evidence of the toxic effects of NPs, as they altered the measured  parameters in the blood, and suggests further research to better understand the environmental fate of NPs.

Makale detayları

Effects of aluminum, copper, and titanium nanoparticles on some blood parameters in Wistar rats

Yazarlar: ESİN GÜLNAZ CANLI | MUSTAFA CANLI

Yayıncı: TUBITAK

Ana Başlıklar: Zooloji bilimleri/Hayvanlar

Dergi: Turkish Journal of Zoology 2017 Vol.41 Issue 2, pp.259-266

Belge Tipi: Makale

Yayın Tarihi: 3/2017

Belge Dili: İngilizce

Document ID (Org No.): 2000774117

Sıklık: İki Aylık

eISSN: 1303-6114

pISSN: 1300-0179

Sayı

Yazarlar:

ESİN GÜLNAZ CANLI | MUSTAFA CANLI

Yayıncı:

TUBITAK

Ana Başlıklar:

Zooloji bilimleri/Hayvanlar

Dergi:

Turkish Journal of Zoology 2017 Vol.41 Issue 2, pp.259-266

Belge Tipi:

Makale

Yayın Tarihi:

3/2017

Belge Dili:

İngilizce

Document ID (Org No.):

2000774117

Sıklık:

İki Aylık

eISSN:

1303-6114

pISSN:

1300-0179