The Effect of Temperature on the Enantioselectivity of Lipase-Catalyzed Reactions; Case Study: Isopropylidene Glycerol Reaction

Adnan AYDEMİR

Makale detayları

The Effect of Temperature on the Enantioselectivity of Lipase-Catalyzed Reactions; Case Study: Isopropylidene Glycerol Reaction

Yazarlar:

Adnan AYDEMİR

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Kimya mühendisliği

Dergi:

Journal of the Turkish Chemical Society Section B: Chemical Engineering 2022 Vol.5 Issue 1, pp.29-38

Belge Tipi:

Makale

Yayın Tarihi:

5/2022

Belge Dili:

İngilizce

Document ID (Org No.):

2000504278

Sıklık:

İki Yıllık

eISSN:

2564-6907

Özet:

 

Commercial lipase (triacylglycerol lipase (EC 3.1.1.3) of Burkholderia cepacia (40 U/mg) in its crude form has been used in the kinetic resolution of enzyme-catalyzed reaction of 1,2-O-isopropylidene-sn-glycerol and vinyl acetate as acyl donor in the organic solvent n-hexane. It was observed that the enantioselectivity is in the range of 2.295 to 2.235 while ΔΔGD,L -73.408 to -75.682 kJ/mol at 35 °C  and 55 °C, respectively . This shows that any increase in the reaction temperature led to an increased final conversion, but it has no effect on the enantioselectivity of the reaction. Also, the thermodynamic effect of temperature on the Gibbs free energy in the lipase-catalyzed kinetic resolution of the reaction between racemic isopropylidene glycerol and vinyl acetate remains in the small range. By using this type of analysis, the researchers may predict if they should increase or decrease the temperature to enhance the selectivity of enzyme in catalyzing a reaction.

Makale detayları

The Effect of Temperature on the Enantioselectivity of Lipase-Catalyzed Reactions; Case Study: Isopropylidene Glycerol Reaction

Yazarlar: Adnan AYDEMİR

Yayıncı: Turkish Chemical Society

Ana Başlıklar: Kimya mühendisliği

Dergi: Journal of the Turkish Chemical Society Section B: Chemical Engineering 2022 Vol.5 Issue 1, pp.29-38

Belge Tipi: Makale

Yayın Tarihi: 5/2022

Belge Dili: İngilizce

Document ID (Org No.): 2000504278

Sıklık: İki Yıllık

eISSN: 2564-6907

Sayı

Yazarlar:

Adnan AYDEMİR

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Kimya mühendisliği

Dergi:

Journal of the Turkish Chemical Society Section B: Chemical Engineering 2022 Vol.5 Issue 1, pp.29-38

Belge Tipi:

Makale

Yayın Tarihi:

5/2022

Belge Dili:

İngilizce

Document ID (Org No.):

2000504278

Sıklık:

İki Yıllık

eISSN:

2564-6907