Synthesis, Characterization and Investigation of Antimicrobial Activity of Orthophtaldehyde Nanoflowers

Gülten Can Sezgin; Nilay Ildiz

Makale detayları

Synthesis, Characterization and Investigation of Antimicrobial Activity of Orthophtaldehyde Nanoflowers

Yazarlar:

Gülten Can Sezgin | Nilay Ildiz

Yayıncı:

Ordu University

Ana Başlıklar:

Health Care Administration

Dergi:

Middle Black Sea Journal of Health Science Vol.9 Issue 2, pp.245-255

Belge Tipi:

Makale

Yayın Tarihi:

5/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001290758

pISSN:

2149-7796

Anahtar kelimeler:

Özet:

 Objective: Endoscopy procedures are frequently performed in gastroenterology clinics, and disinfection cost, corrosion and toxicity are important problems in this area. For this purpose, hybrid nanoflowers at various pHs were synthesized with orthophtaldehyde OPA, which has an important in disinfection in these clinics, and the hybrid nanostructures obtained by reducing the amount of orthophtaldehyde use were aimed to also increase the effectiveness of the disinfectant. Methods: OPA nanoflowers OPA NFs were synthesized and their effective diameters hydrodynamic diameters and surface charges were determined by dynamic light scattering DLS and Zeta potential ZP measurements, respectively. Antimicrobial activities of orthophtaldehyde and OPA NFs against Staphylococcus aureus S. aureus ATCC 25923, Escherichia coli E. coli ATCC 35218 and Candida albicans C. albicans ATCC 90028 standard strains were evaluated by the liquid microdilution method using percent inhibition method. Results: OPA-based OPA-Cu2hybridnano flowers OPANF were synthesized successfully at different pH values pH 7.4, 9 and 11. The most effective antimicrobial activity was observed in the nanoflowers synthesized at pH7.4 for all tested microorganisms. Although the antimicrobial activity decreased as the pH value increased, NFs activity was higher than OPA alone at all pH values p0.001. In this study, NFs synthesized with 0.02 mgml OPA were found to be 5.2 times more effective for C.albicans, 5.75 times for E.coli and 4.4 times for S.aureus than OPA0.02 mgml. Conclusion: NFs showed very high antimicrobial activity compared to OPA and also promise to be a preferred agent in medical device disinfection providing a high level of disinfection with the use of a few amounts of OPA that use in clinics.

 Objective: Endoscopy procedures are frequently performed in gastroenterology clinics, and disinfection cost, corrosion and toxicity are important problems in this area. For this purpose, hybrid nanoflowers at various pHs were synthesized with orthophtaldehyde OPA, which has an important in disinfection in these clinics, and the hybrid nanostructures obtained by reducing the amount of orthophtaldehyde use were aimed to also increase the effectiveness of the disinfectant. Methods: OPA nanoflowers OPA NFs were synthesized and their effective diameters hydrodynamic diameters and surface charges were determined by dynamic light scattering DLS and Zeta potential ZP measurements, respectively. Antimicrobial activities of orthophtaldehyde and OPA NFs against Staphylococcus aureus S. aureus ATCC 25923, Escherichia coli E. coli ATCC 35218 and Candida albicans C. albicans ATCC 90028 standard strains were evaluated by the liquid microdilution method using percent inhibition method. Results: OPA-based OPA-Cu2hybridnano flowers OPANF were synthesized successfully at different pH values pH 7.4, 9 and 11. The most effective antimicrobial activity was observed in the nanoflowers synthesized at pH7.4 for all tested microorganisms. Although the antimicrobial activity decreased as the pH value increased, NFs activity was higher than OPA alone at all pH values p0.001. In this study, NFs synthesized with 0.02 mgml OPA were found to be 5.2 times more effective for C.albicans, 5.75 times for E.coli and 4.4 times for S.aureus than OPA0.02 mgml. Conclusion: NFs showed very high antimicrobial activity compared to OPA and also promise to be a preferred agent in medical device disinfection providing a high level of disinfection with the use of a few amounts of OPA that use in clinics.

 Objective: Endoscopy procedures are frequently performed in gastroenterology clinics, and disinfection cost, corrosion and toxicity are important problems in this area. For this purpose, hybrid nanoflowers at various pHs were synthesized with orthophtaldehyde OPA, which has an important in disinfection in these clinics, and the hybrid nanostructures obtained by reducing the amount of orthophtaldehyde use were aimed to also increase the effectiveness of the disinfectant. Methods: OPA nanoflowers OPA NFs were synthesized and their effective diameters hydrodynamic diameters and surface charges were determined by dynamic light scattering DLS and Zeta potential ZP measurements, respectively. Antimicrobial activities of orthophtaldehyde and OPA NFs against Staphylococcus aureus S. aureus ATCC 25923, Escherichia coli E. coli ATCC 35218 and Candida albicans C. albicans ATCC 90028 standard strains were evaluated by the liquid microdilution method using percent inhibition method. Results: OPA-based OPA-Cu2hybridnano flowers OPANF were synthesized successfully at different pH values pH 7.4, 9 and 11. The most effective antimicrobial activity was observed in the nanoflowers synthesized at pH7.4 for all tested microorganisms. Although the antimicrobial activity decreased as the pH value increased, NFs activity was higher than OPA alone at all pH values p0.001. In this study, NFs synthesized with 0.02 mgml OPA were found to be 5.2 times more effective for C.albicans, 5.75 times for E.coli and 4.4 times for S.aureus than OPA0.02 mgml. Conclusion: NFs showed very high antimicrobial activity compared to OPA and also promise to be a preferred agent in medical device disinfection providing a high level of disinfection with the use of a few amounts of OPA that use in clinics.

 Objective: Endoscopy procedures are frequently performed in gastroenterology clinics, and disinfection cost, corrosion and toxicity are important problems in this area. For this purpose, hybrid nanoflowers at various pHs were synthesized with orthophtaldehyde OPA, which has an important in disinfection in these clinics, and the hybrid nanostructures obtained by reducing the amount of orthophtaldehyde use were aimed to also increase the effectiveness of the disinfectant. Methods: OPA nanoflowers OPA NFs were synthesized and their effective diameters hydrodynamic diameters and surface charges were determined by dynamic light scattering DLS and Zeta potential ZP measurements, respectively. Antimicrobial activities of orthophtaldehyde and OPA NFs against Staphylococcus aureus S. aureus ATCC 25923, Escherichia coli E. coli ATCC 35218 and Candida albicans C. albicans ATCC 90028 standard strains were evaluated by the liquid microdilution method using percent inhibition method. Results: OPA-based OPA-Cu2hybridnano flowers OPANF were synthesized successfully at different pH values pH 7.4, 9 and 11. The most effective antimicrobial activity was observed in the nanoflowers synthesized at pH7.4 for all tested microorganisms. Although the antimicrobial activity decreased as the pH value increased, NFs activity was higher than OPA alone at all pH values p0.001. In this study, NFs synthesized with 0.02 mgml OPA were found to be 5.2 times more effective for C.albicans, 5.75 times for E.coli and 4.4 times for S.aureus than OPA0.02 mgml. Conclusion: NFs showed very high antimicrobial activity compared to OPA and also promise to be a preferred agent in medical device disinfection providing a high level of disinfection with the use of a few amounts of OPA that use in clinics.

Makale detayları

Synthesis, Characterization and Investigation of Antimicrobial Activity of Orthophtaldehyde Nanoflowers

Yazarlar:

Gülten Can Sezgin | Nilay Ildiz

Yayıncı:

Ordu University

Ana Başlıklar:

Health Care Administration

Dergi:

Middle Black Sea Journal of Health Science Vol.9 Issue 2, pp.245-255

Belge Tipi:

Makale

Yayın Tarihi:

5/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001290758

pISSN:

2149-7796

disinfection

endoscopy

nanoflower

orthophthaldehydedisinfection

endoscopy

nanoflower

orthophthaldehyde

Sayı

Makale detayları

Yazarlar: Gülten Can Sezgin | Nilay Ildiz

Yayıncı: Ordu University

Ana Başlıklar: Health Care Administration

Dergi: Middle Black Sea Journal of Health Science Vol.9 Issue 2, pp.245-255

Belge Tipi: Makale

Yayın Tarihi: 5/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001290758

pISSN: 2149-7796

Sayı

Yazarlar:

Gülten Can Sezgin | Nilay Ildiz

Yayıncı:

Ordu University

Ana Başlıklar:

Health Care Administration

Dergi:

Middle Black Sea Journal of Health Science Vol.9 Issue 2, pp.245-255

Belge Tipi:

Makale

Yayın Tarihi:

5/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001290758

pISSN:

2149-7796