Identification of Free Radicals Formed in Gamma-Irradiated Chlorpropamide and Procainamide Hydrochloride Pharmaceutical Raw Materials by EPR Spectroscopy

Kerem Sütçü; Yunus Emre Osmanoğlu

Makale detayları

Identification of Free Radicals Formed in Gamma-Irradiated Chlorpropamide and Procainamide Hydrochloride Pharmaceutical Raw Materials by EPR Spectroscopy

Yazarlar:

Kerem Sütçü | Yunus Emre Osmanoğlu

Yayıncı:

Igdir University

Ana Başlıklar:

Metroloji | Uygulamalı ve Endüstriyel Fizik

Dergi:

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.13 Issue 4, pp.2616-2621

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001302944

pISSN:

2536-4618

Anahtar kelimeler:

Özet:

 In this study, it was aimed to determine the structural properties of free radicals formed by gamma irradiation in chlorpropamide and procainamide hydrochloride drug raw materials, which are widely used in medicine, by using electron paramagnetic resonance spectroscopy. As a result of gamma irradiation, it was determined that two different radicals were formed in both chlorpropamide and procainamide hydrochloride samples. It was suggested that NĊH-, -NCH2ĊH2- and NĊH-, -NĊHCH2- radicals were formed in chlorpropamide and procainamide hydrochloride samples, respectively. The simulated spectra closest to the experimental spectra recorded at room temperature of the samples studied in powder form were obtained using simulation software. The contributions of the proposed radicals to the experimental spectra were calculated. The g values of the obtained radicals and the hyperfine structure constants of the unpaired electrons were calculated.

 In this study, it was aimed to determine the structural properties of free radicals formed by gamma irradiation in chlorpropamide and procainamide hydrochloride drug raw materials, which are widely used in medicine, by using electron paramagnetic resonance spectroscopy. As a result of gamma irradiation, it was determined that two different radicals were formed in both chlorpropamide and procainamide hydrochloride samples. It was suggested that NĊH-, -NCH2ĊH2- and NĊH-, -NĊHCH2- radicals were formed in chlorpropamide and procainamide hydrochloride samples, respectively. The simulated spectra closest to the experimental spectra recorded at room temperature of the samples studied in powder form were obtained using simulation software. The contributions of the proposed radicals to the experimental spectra were calculated. The g values of the obtained radicals and the hyperfine structure constants of the unpaired electrons were calculated.

 In this study, it was aimed to determine the structural properties of free radicals formed by gamma irradiation in chlorpropamide and procainamide hydrochloride drug raw materials, which are widely used in medicine, by using electron paramagnetic resonance spectroscopy. As a result of gamma irradiation, it was determined that two different radicals were formed in both chlorpropamide and procainamide hydrochloride samples. It was suggested that NĊH-, -NCH2ĊH2- and NĊH-, -NĊHCH2- radicals were formed in chlorpropamide and procainamide hydrochloride samples, respectively. The simulated spectra closest to the experimental spectra recorded at room temperature of the samples studied in powder form were obtained using simulation software. The contributions of the proposed radicals to the experimental spectra were calculated. The g values of the obtained radicals and the hyperfine structure constants of the unpaired electrons were calculated.

 Bu çalışmada tıpta yaygın kullanılan klorpropamid ve prokainamid hidroklorür ilaç hammaddelerinde gama ile ışınlanarak oluşan serbest radikallerin yapısal özelliklerinin elektron paramanyetik rezonans spektroskopisi kullanılarak belirlenmesi amaçlanmıştır. Gama ile ışınlama sonucunda hem klorpropamid ve hem de prokainamid hidroklorür numunelerinde iki farklı radikal oluştuğu tespit edilmiştir. Klorpropamid ve prokainamid hidroklorür numunelerinde sırasıyla -NĊH-, -NCH2ĊH2- ve NĊH-, -NĊHCH- radikallerinin oluştuğu önerilmiştir. Toz formunda çalışılan örneklerin oda sıcaklığında kaydedilmiş deneysel spektrumlarına en yakın simüle spektrumları simülasyon yazılımı kullanılarak elde edilmiştir. Önerilen radikallerin deneysel spektrumlara olan katkıları hesaplanmıştır. Elde edilen radikallerin g değerleri ve eşlenmemiş elektronların aşırı ince yapı sabitleri hesaplanmıştır.

Makale detayları

Identification of Free Radicals Formed in Gamma-Irradiated Chlorpropamide and Procainamide Hydrochloride Pharmaceutical Raw Materials by EPR Spectroscopy

Yazarlar:

Kerem Sütçü | Yunus Emre Osmanoğlu

Yayıncı:

Igdir University

Ana Başlıklar:

Metroloji | Uygulamalı ve Endüstriyel Fizik

Dergi:

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.13 Issue 4, pp.2616-2621

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001302944

pISSN:

2536-4618

Electron paramagnetic resonance

Gamma irradiation

Pharmaceutical raw materialElektron paramanyetik rezonans

Gama ışınlaması

İlaç hammaddesi

Sayı

Makale detayları

Identification of Free Radicals Formed in Gamma-Irradiated Chlorpropamide and Procainamide Hydrochloride Pharmaceutical Raw Materials by EPR Spectroscopy

Yazarlar: Kerem Sütçü | Yunus Emre Osmanoğlu

Yayıncı: Igdir University

Ana Başlıklar: Metroloji | Uygulamalı ve Endüstriyel Fizik

Dergi: Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.13 Issue 4, pp.2616-2621

Belge Tipi: Makale

Yayın Tarihi: 1/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001302944

pISSN: 2536-4618

Electron paramagnetic resonance

Gamma irradiation

Pharmaceutical raw materialElektron paramanyetik rezonans

Gama ışınlaması

İlaç hammaddesi

Sayı

Yazarlar:

Kerem Sütçü | Yunus Emre Osmanoğlu

Yayıncı:

Igdir University

Ana Başlıklar:

Metroloji | Uygulamalı ve Endüstriyel Fizik

Dergi:

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.13 Issue 4, pp.2616-2621

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001302944

pISSN:

2536-4618