Brain in metabolic syndrome model: The effect of exercises and caloric restriction

Burcin Alev; Nevin Genç Kahraman; Hazal İpekçi; Ünsal Veli Üstündağ; Tuğba Tunalı-akbay; Ebru Emekli Alturfan; Göksel Şener; Aysen Yarat

Makale detayları

Brain in metabolic syndrome model: The effect of exercises and caloric restriction

Yazarlar:

Burcin Alev | Nevin Genç Kahraman | Hazal İpekçi | Ünsal Veli Üstündağ | Tuğba Tunalı-akbay | Ebru Emekli Alturfan | Göksel Şener | Aysen Yarat

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Sciences

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 5, pp.1352-1362

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347554

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Caloric restriction CR and exercise EX have impacts on improving metabolic risk factors. This study aimed to investigate the changes in the brain after EX andor CR in metabolic syndrome MeS induced by a high fructose diet in rats. Sprague-Dawley male rats were divided into five groups. Drinking water including 10 fructose solution was given to rats for 12 weeks to develop a MeS rat model. Animals with MeS were submitted to EX andor CR for 6 weeks. Blood glucose, and brain tissue damage and antioxidant parameters were measured. Brain lipid peroxidation, sialic acid, mucin, fucose levels increased in the MeS group compared to the control C group. These parameters reduced significantly in the metabolic syndrome with caloric restriction MeSCR group, and more significantly in the metabolic syndrome with exercise and caloric restriction group MeSEXCR, compared to the MeS group. Glutathione levels, superoxide dismutase and catalase activities decreased in the MeS group compared to the C group, increased both in the MeSCR group, and MeSEXCR group compared to the MeS group. High fructose diet consumption can lead to brain tissue damage and decreased antioxidant levels were found to be improved best in the MeSEXCR group.

 Caloric restriction CR and exercise EX have impacts on improving metabolic risk factors. This study aimed to investigate the changes in the brain after EX andor CR in metabolic syndrome MeS induced by a high fructose diet in rats. Sprague-Dawley male rats were divided into five groups. Drinking water including 10 fructose solution was given to rats for 12 weeks to develop a MeS rat model. Animals with MeS were submitted to EX andor CR for 6 weeks. Blood glucose, and brain tissue damage and antioxidant parameters were measured. Brain lipid peroxidation, sialic acid, mucin, fucose levels increased in the MeS group compared to the control C group. These parameters reduced significantly in the metabolic syndrome with caloric restriction MeSCR group, and more significantly in the metabolic syndrome with exercise and caloric restriction group MeSEXCR, compared to the MeS group. Glutathione levels, superoxide dismutase and catalase activities decreased in the MeS group compared to the C group, increased both in the MeSCR group, and MeSEXCR group compared to the MeS group. High fructose diet consumption can lead to brain tissue damage and decreased antioxidant levels were found to be improved best in the MeSEXCR group.

 Caloric restriction CR and exercise EX have impacts on improving metabolic risk factors. This study aimed to investigate the changes in the brain after EX andor CR in metabolic syndrome MeS induced by a high fructose diet in rats. Sprague-Dawley male rats were divided into five groups. Drinking water including 10 fructose solution was given to rats for 12 weeks to develop a MeS rat model. Animals with MeS were submitted to EX andor CR for 6 weeks. Blood glucose, and brain tissue damage and antioxidant parameters were measured. Brain lipid peroxidation, sialic acid, mucin, fucose levels increased in the MeS group compared to the control C group. These parameters reduced significantly in the metabolic syndrome with caloric restriction MeSCR group, and more significantly in the metabolic syndrome with exercise and caloric restriction group MeSEXCR, compared to the MeS group. Glutathione levels, superoxide dismutase and catalase activities decreased in the MeS group compared to the C group, increased both in the MeSCR group, and MeSEXCR group compared to the MeS group. High fructose diet consumption can lead to brain tissue damage and decreased antioxidant levels were found to be improved best in the MeSEXCR group.

 Caloric restriction CR and exercise EX have impacts on improving metabolic risk factors. This study aimed to investigate the changes in the brain after EX andor CR in metabolic syndrome MeS induced by a high fructose diet in rats. Sprague-Dawley male rats were divided into five groups. Drinking water including 10 fructose solution was given to rats for 12 weeks to develop a MeS rat model. Animals with MeS were submitted to EX andor CR for 6 weeks. Blood glucose, and brain tissue damage and antioxidant parameters were measured. Brain lipid peroxidation, sialic acid, mucin, fucose levels increased in the MeS group compared to the control C group. These parameters reduced significantly in the metabolic syndrome with caloric restriction MeSCR group, and more significantly in the metabolic syndrome with exercise and caloric restriction group MeSEXCR, compared to the MeS group. Glutathione levels, superoxide dismutase and catalase activities decreased in the MeS group compared to the C group, increased both in the MeSCR group, and MeSEXCR group compared to the MeS group. High fructose diet consumption can lead to brain tissue damage and decreased antioxidant levels were found to be improved best in the MeSEXCR group.

Makale detayları

Brain in metabolic syndrome model: The effect of exercises and caloric restriction

Yazarlar:

Burcin Alev | Nevin Genç Kahraman | Hazal İpekçi | Ünsal Veli Üstündağ | Tuğba Tunalı-akbay | Ebru Emekli Alturfan | Göksel Şener | Aysen Yarat

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Sciences

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 5, pp.1352-1362

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347554

pISSN:

2630-6344

Metabolic syndrome

Brain

Antioxidant

Oxidative stress

Exercise

Caloric restriction

Sayı

Makale detayları

Brain in metabolic syndrome model: The effect of exercises and caloric restriction

Yazarlar: Burcin Alev | Nevin Genç Kahraman | Hazal İpekçi | Ünsal Veli Üstündağ | Tuğba Tunalı-akbay | Ebru Emekli Alturfan | Göksel Şener | Aysen Yarat

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Sciences

Dergi: Journal of Research in Pharmacy Vol.26 Issue 5, pp.1352-1362

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347554

pISSN: 2630-6344

Metabolic syndrome

Brain

Antioxidant

Oxidative stress

Exercise

Caloric restriction

Sayı

Yazarlar:

Burcin Alev | Nevin Genç Kahraman | Hazal İpekçi | Ünsal Veli Üstündağ | Tuğba Tunalı-akbay | Ebru Emekli Alturfan | Göksel Şener | Aysen Yarat

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Sciences

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 5, pp.1352-1362

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347554

pISSN:

2630-6344