Cytotoxic effects of Mannich bases via induction of caspase-3 pathway on human oral squamous cell carcinoma

Cem YAMALI; Halise İnci GÜL

doi:https://doi.org/10.18596/jotcsa.817007

Makale detayları

Cytotoxic effects of Mannich bases via induction of caspase-3 pathway on human oral squamous cell carcinoma

Yazarlar:

Cem YAMALI | Halise İnci GÜL

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Kimya ve ilgili bilimler

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry 2021 Vol.8 Issue 1, pp.187-194

Belge Tipi:

Makale

Yayın Tarihi:

2/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000502428

Sıklık:

Üç Aylık

eISSN:

2149-0120

DOI:

https://doi.org/10.18596/jotcsa.817007

Özet:

 

In anticancer drug research, there is a need for the synthesis of compounds with selective cytotoxicity compared to the drugs in the market. The current study aimed to determine the cytotoxicities of the bis Mannich bases 1-9  towards human oral squamous cell carcinoma (OSCC). Mannich bases showed cytotoxicity in low micromolar in the range of 1.7-27 µM against OSCC cell lines. The compounds 5 with the highest potency selectivity expression (PSE) value (318.1) and 7  with the highest tumor selectivity (TS) values (TS1:11.2, TS2:15.8) showed promising selective cytotoxicity towards cancer cell lines. According to Western blot analysis, representative compound 7 induced the activation of caspase-3 in HSC-2 cells. These results may suggest that the apoptosis pathway may be one of the possible mechanisms of the actions and lead compound 7 can be subjected to further bioassays.

Makale detayları

Cytotoxic effects of Mannich bases via induction of caspase-3 pathway on human oral squamous cell carcinoma

Yazarlar: Cem YAMALI | Halise İnci GÜL

Yayıncı: Turkish Chemical Society

Ana Başlıklar: Kimya ve ilgili bilimler

Dergi: Journal of the Turkish Chemical Society Section A: Chemistry 2021 Vol.8 Issue 1, pp.187-194

Belge Tipi: Makale

Yayın Tarihi: 2/2021

Belge Dili: İngilizce

Document ID (Org No.): 2000502428

Sıklık: Üç Aylık

eISSN: 2149-0120

DOI: https://doi.org/10.18596/jotcsa.817007

Sayı

Yazarlar:

Cem YAMALI | Halise İnci GÜL

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Kimya ve ilgili bilimler

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry 2021 Vol.8 Issue 1, pp.187-194

Belge Tipi:

Makale

Yayın Tarihi:

2/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000502428

Sıklık:

Üç Aylık

eISSN:

2149-0120

DOI:

https://doi.org/10.18596/jotcsa.817007