Autoinflammatory diseases in children

Donato RIGANTE

Makale detayları

Autoinflammatory diseases in children

Yazarlar:

Donato RIGANTE

Yayıncı:

Bilal YILDIZ

Dergi:

Journal of Pediatric Sciences 2010 Vol.2 Issue 4

Belge Tipi:

Makale

Yayın Tarihi:

8/2010

Belge Dili:

İngilizce

Document ID (Org No.):

2000743651

Sıklık:

İki Yıllık

eISSN:

1309-1247

Özet:

 

Autoinflammatory diseases encompass a growing number of multisystem clinical entities with genetic or acquired defects in the innate immune system. Distinct conditions can be identified in this expanding sphere: familial Mediterranean fever, mevalonate kinase deficiency, tumor necrosis factor receptor-associated periodic syndrome, cryopyrinopathies, idiopathic febrile syndromes, hereditary pyogenic disorders, pediatric granulomatous arthritides, complement dysregulation syndromes and Behçet's disease. All these multifaceted conditions display episodes of seemingly unprovoked inflammation of variable duration and different severity. The main limitation to their better knowledge is the extreme fragmentation of the diagnosed cases that are spread over different centres and countries. The discovery of new molecules involved in recognizing exogenous and endogenous danger signals that lead to inflammatory responses has allowed to understand the pathways of innate immunity and to disclose new therapeutic perspectives for children with autoinflammatory diseases.

Makale detayları

Autoinflammatory diseases in children

Yazarlar: Donato RIGANTE

Yayıncı: Bilal YILDIZ

Dergi: Journal of Pediatric Sciences 2010 Vol.2 Issue 4

Belge Tipi: Makale

Yayın Tarihi: 8/2010

Belge Dili: İngilizce

Document ID (Org No.): 2000743651

Sıklık: İki Yıllık

eISSN: 1309-1247

Sayı

Yazarlar:

Donato RIGANTE

Yayıncı:

Bilal YILDIZ

Dergi:

Journal of Pediatric Sciences 2010 Vol.2 Issue 4

Belge Tipi:

Makale

Yayın Tarihi:

8/2010

Belge Dili:

İngilizce

Document ID (Org No.):

2000743651

Sıklık:

İki Yıllık

eISSN:

1309-1247