Reduced central nervous 5-HT neurotransmission in youth with ADHD influences ratings of a virtual opponents`extraversion aâ‚¬“ Effects of trait-aggression

Florian Zepf; Tilman GABER; Sarah BUBENZER; David BAURMANN; Katrin HELMBOLD; Timo VLOET; Martin HOLTMANN; Sophie MAGNUS; Fritz POUSTKA; Lars WÖCKEL

Makale detayları

Reduced central nervous 5-HT neurotransmission in youth with ADHD influences ratings of a virtual opponents`extraversion aâ‚¬“ Effects of trait-aggression

Yazarlar:

Florian Zepf | Tilman GABER | Sarah BUBENZER | David BAURMANN | Katrin HELMBOLD | Timo VLOET | Martin HOLTMANN | Sophie MAGNUS | Fritz POUSTKA | Lars WÖCKEL

Yayıncı:

Bilal YILDIZ

Dergi:

Journal of Pediatric Sciences 2011 Vol.3 Issue 2, pp.1-12

Belge Tipi:

Makale

Yayın Tarihi:

4/2011

Belge Dili:

İngilizce

Document ID (Org No.):

2000743576

Sıklık:

İki Yıllık

eISSN:

1309-1247

Özet:

 

Objective: Evidence from animal and human studies suggests that the neurobiology of aggressive behaviour and extraversion is linked with changes in serotonergic (5-HT) neurotransmission. The present study investigated the effects of diminished central nervous 5-HT neurotransmission following rapid tryptophan depletion (RTD) in youth diagnosed with attention deficit/hyperactivity disorder (ADHD). The study assessed the participants' opponent ratings after the experience of competing against a fictitious opponent in a competitive reaction time game (CRT) whilst under the influence of depletion/placebo. Method: 22 boys diagnosed with ADHD were subjected to a double-blind within-subject crossover-design, receiving RTD on one day, and on a further day a tryptophan balanced placebo. 4.5 hours after RTD/placebo intake they were subjected to provocation of aggressive behaviour using the CRT and asked to produce  opponent ratings. Results: aâ‚¬Å“Low aggressiveaâ‚¬ boys showed significantly higher extraversion ratings of their fictitious opponent compared to those of aâ‚¬Å“high aggressiveaâ‚¬ boys under RTD versus placebo. Conclusion: The data support evidence that changes in 5-HT neurotransmission are involved in the neurobiological underpinnings of extraversion experienced by children and adolescents with ADHD. Future research with healthy controls and both genders is required to control for developmental and disorder-related effects.

Makale detayları

Reduced central nervous 5-HT neurotransmission in youth with ADHD influences ratings of a virtual opponents`extraversion aâ‚¬“ Effects of trait-aggression

Yazarlar: Florian Zepf | Tilman GABER | Sarah BUBENZER | David BAURMANN | Katrin HELMBOLD | Timo VLOET | Martin HOLTMANN | Sophie MAGNUS | Fritz POUSTKA | Lars WÖCKEL

Yayıncı: Bilal YILDIZ

Dergi: Journal of Pediatric Sciences 2011 Vol.3 Issue 2, pp.1-12

Belge Tipi: Makale

Yayın Tarihi: 4/2011

Belge Dili: İngilizce

Document ID (Org No.): 2000743576

Sıklık: İki Yıllık

eISSN: 1309-1247

Sayı

Yazarlar:

Florian Zepf | Tilman GABER | Sarah BUBENZER | David BAURMANN | Katrin HELMBOLD | Timo VLOET | Martin HOLTMANN | Sophie MAGNUS | Fritz POUSTKA | Lars WÖCKEL

Yayıncı:

Bilal YILDIZ

Dergi:

Journal of Pediatric Sciences 2011 Vol.3 Issue 2, pp.1-12

Belge Tipi:

Makale

Yayın Tarihi:

4/2011

Belge Dili:

İngilizce

Document ID (Org No.):

2000743576

Sıklık:

İki Yıllık

eISSN:

1309-1247