Studies on a novel series of 3(2H)-pyridazinones: Synthesis, molecular modelling, antimicrobial activity

Zeynep Özdemir; Mehmet Abdullah Alagöz; Azime Berna Özçelik; Berrin Özçelik; Mehtap Uysal

Makale detayları

Studies on a novel series of 3(2H)-pyridazinones: Synthesis, molecular modelling, antimicrobial activity

Yazarlar:

Zeynep Özdemir | Mehmet Abdullah Alagöz | Azime Berna Özçelik | Berrin Özçelik | Mehtap Uysal

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Chemistry | Pharmaceutical Microbiology

Dergi:

Journal of Research in Pharmacy Vol.23 Issue 5, pp.960-972

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347984

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Efforts to develop new potent and effective antimicrobial compounds with lower side effects are important not only for controlling serious infections but also for cancer, surgical operations, and preventing possible infections which are related to other threats. Therefore, it is getting more important to develop new antibacterial and antifungal compounds with wide spectrum, systemic effect and lower side effects. In this study eight new 32H- pyridazinone derivatives were synthesized and their antimicrobial activities were evaluated by using broth microdilution method agains two Gr  Staphylococcus aureus, Enterococcus faecalis, two Gr - bacteria Pseudomonas aeruginosa, Escherichia coli and three yeasts like fungi Candida albicans, Candida krusei. Compound D2a had the best antibacterial activity among the synthesized compounds. All compounds were more effective against the fungus than the bacteria. In this study, we performed molecular modelling studies to provide in depth understanding of their CYP51 inhibition. Antifungal susceptibility tests against standard Candida spp. including C. albicans revealed D2aas highly active compound. The molecular docking studies showed similarities in binding interactions in active site gorges of the enzymes with known inhibitors, such as VT1, fluconazole.

 Efforts to develop new potent and effective antimicrobial compounds with lower side effects are important not only for controlling serious infections but also for cancer, surgical operations, and preventing possible infections which are related to other threats. Therefore, it is getting more important to develop new antibacterial and antifungal compounds with wide spectrum, systemic effect and lower side effects. In this study eight new 32H- pyridazinone derivatives were synthesized and their antimicrobial activities were evaluated by using broth microdilution method agains two Gr  Staphylococcus aureus, Enterococcus faecalis, two Gr - bacteria Pseudomonas aeruginosa, Escherichia coli and three yeasts like fungi Candida albicans, Candida krusei. Compound D2a had the best antibacterial activity among the synthesized compounds. All compounds were more effective against the fungus than the bacteria. In this study, we performed molecular modelling studies to provide in depth understanding of their CYP51 inhibition. Antifungal susceptibility tests against standard Candida spp. including C. albicans revealed D2aas highly active compound. The molecular docking studies showed similarities in binding interactions in active site gorges of the enzymes with known inhibitors, such as VT1, fluconazole.

 Efforts to develop new potent and effective antimicrobial compounds with lower side effects are important not only for controlling serious infections but also for cancer, surgical operations, and preventing possible infections which are related to other threats. Therefore, it is getting more important to develop new antibacterial and antifungal compounds with wide spectrum, systemic effect and lower side effects. In this study eight new 32H- pyridazinone derivatives were synthesized and their antimicrobial activities were evaluated by using broth microdilution method agains two Gr  Staphylococcus aureus, Enterococcus faecalis, two Gr - bacteria Pseudomonas aeruginosa, Escherichia coli and three yeasts like fungi Candida albicans, Candida krusei. Compound D2a had the best antibacterial activity among the synthesized compounds. All compounds were more effective against the fungus than the bacteria. In this study, we performed molecular modelling studies to provide in depth understanding of their CYP51 inhibition. Antifungal susceptibility tests against standard Candida spp. including C. albicans revealed D2aas highly active compound. The molecular docking studies showed similarities in binding interactions in active site gorges of the enzymes with known inhibitors, such as VT1, fluconazole.

 Efforts to develop new potent and effective antimicrobial compounds with lower side effects are important not only for controlling serious infections but also for cancer, surgical operations, and preventing possible infections which are related to other threats. Therefore, it is getting more important to develop new antibacterial and antifungal compounds with wide spectrum, systemic effect and lower side effects. In this study eight new 32H- pyridazinone derivatives were synthesized and their antimicrobial activities were evaluated by using broth microdilution method agains two Gr  Staphylococcus aureus, Enterococcus faecalis, two Gr - bacteria Pseudomonas aeruginosa, Escherichia coli and three yeasts like fungi Candida albicans, Candida krusei. Compound D2a had the best antibacterial activity among the synthesized compounds. All compounds were more effective against the fungus than the bacteria. In this study, we performed molecular modelling studies to provide in depth understanding of their CYP51 inhibition. Antifungal susceptibility tests against standard Candida spp. including C. albicans revealed D2aas highly active compound. The molecular docking studies showed similarities in binding interactions in active site gorges of the enzymes with known inhibitors, such as VT1, fluconazole.

Makale detayları

Studies on a novel series of 3(2H)-pyridazinones: Synthesis, molecular modelling, antimicrobial activity

Yazarlar:

Zeynep Özdemir | Mehmet Abdullah Alagöz | Azime Berna Özçelik | Berrin Özçelik | Mehtap Uysal

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Chemistry | Pharmaceutical Microbiology

Dergi:

Journal of Research in Pharmacy Vol.23 Issue 5, pp.960-972

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347984

pISSN:

2630-6344

3(2H)-Pyridazinones

antibacterial

antifungal

antimicrobial

molecular modelling

Sayı

Makale detayları

Studies on a novel series of 3(2H)-pyridazinones: Synthesis, molecular modelling, antimicrobial activity

Yazarlar: Zeynep Özdemir | Mehmet Abdullah Alagöz | Azime Berna Özçelik | Berrin Özçelik | Mehtap Uysal

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Chemistry | Pharmaceutical Microbiology

Dergi: Journal of Research in Pharmacy Vol.23 Issue 5, pp.960-972

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347984

pISSN: 2630-6344

3(2H)-Pyridazinones

antibacterial

antifungal

antimicrobial

molecular modelling

Sayı

Yazarlar:

Zeynep Özdemir | Mehmet Abdullah Alagöz | Azime Berna Özçelik | Berrin Özçelik | Mehtap Uysal

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Chemistry | Pharmaceutical Microbiology

Dergi:

Journal of Research in Pharmacy Vol.23 Issue 5, pp.960-972

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347984

pISSN:

2630-6344