Preparation and Characterization of an Atenolol Selective Electrode Based on a PVC Matrix Membrane

Nabil S. NASSORY; Shahbaz A. Maki And Mutaz A. ALI; Mutaz A. ALI

Makale detayları

Preparation and Characterization of an Atenolol Selective Electrode Based on a PVC Matrix Membrane

Yazarlar:

Nabil S. NASSORY | Shahbaz A. Maki And Mutaz A. ALI | Mutaz A. ALI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2007 Vol.31 Issue 1, pp.75-82

Belge Tipi:

Makale

Yayın Tarihi:

12/2006

Belge Dili:

Türkçe

Document ID (Org No.):

2000728789

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

Atenolol selective electrodes were prepared based on a  complex atenolol-phosphotungstate as an active material using the  plasticizers di-butyl phosphate (DBP), tri-butyl phosphate (TBP),  o-nitro phenyl octyl ether (NPOE) and di-octyl phthalate (DOPH) in a  PVC matrix membrane.  The properties of the prepared electrodes were  studied, namely slope, concentration range, detection limit, lifetime,  pH effect and selectivity.  The experimental results showed that the  best electrode was based on DOPH as plasticizer, displaying a linear  range from 1.00 x 10-4 M to 5.00 x 10-2 M with a Nernstian slope  of 55.91 mV/decade and correlation coefficient of 0.9995.  The  detection limit was 5.00 x 10-5 M and the lifetime was around 90  days.  The proposed electrode was successfully applied to the  determination of atenolol in a pharmaceutical preparation.  The  average recovery for atenolol determination in tablets was around  98.50%, with standard deviation \pm 0.1.

 

Atenolol selective electrodes were prepared based on a  complex atenolol-phosphotungstate as an active material using the  plasticizers di-butyl phosphate (DBP), tri-butyl phosphate (TBP),  o-nitro phenyl octyl ether (NPOE) and di-octyl phthalate (DOPH) in a  PVC matrix membrane.  The properties of the prepared electrodes were  studied, namely slope, concentration range, detection limit, lifetime,  pH effect and selectivity.  The experimental results showed that the  best electrode was based on DOPH as plasticizer, displaying a linear  range from 1.00 x 10-4 M to 5.00 x 10-2 M with a Nernstian slope  of 55.91 mV/decade and correlation coefficient of 0.9995.  The  detection limit was 5.00 x 10-5 M and the lifetime was around 90  days.  The proposed electrode was successfully applied to the  determination of atenolol in a pharmaceutical preparation.  The  average recovery for atenolol determination in tablets was around  98.50%, with standard deviation \pm 0.1.

Makale detayları

Preparation and Characterization of an Atenolol Selective Electrode Based on a PVC Matrix Membrane

Yazarlar: Nabil S. NASSORY | Shahbaz A. Maki And Mutaz A. ALI | Mutaz A. ALI

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2007 Vol.31 Issue 1, pp.75-82

Belge Tipi: Makale

Yayın Tarihi: 12/2006

Belge Dili: Türkçe

Document ID (Org No.): 2000728789

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Nabil S. NASSORY | Shahbaz A. Maki And Mutaz A. ALI | Mutaz A. ALI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2007 Vol.31 Issue 1, pp.75-82

Belge Tipi:

Makale

Yayın Tarihi:

12/2006

Belge Dili:

Türkçe

Document ID (Org No.):

2000728789

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527