Isatis Glauca Subsp. Sivasica Extract Contributes to Diabetic Wound Healing Process via Increased Collagen and Nitric Oxide Content

Kaan KALTALIOĞLU; Şule Coşkun CEVHER

doi:https://doi.org/10.17350/HJSE19030000224

Makale detayları

Isatis Glauca Subsp. Sivasica Extract Contributes to Diabetic Wound Healing Process via Increased Collagen and Nitric Oxide Content

Yazarlar:

Kaan KALTALIOĞLU | Şule Coşkun CEVHER

Yayıncı:

Hitit University

Ana Başlıklar:

Astronomi ve ilgili bilimler

Dergi:

Hittite Journal of Science and Engineering 2021 Vol.8 Issue 2, pp.141-147

Belge Tipi:

Makale

Yayın Tarihi:

6/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000451287

Sıklık:

Üç Aylık

eISSN:

2148-4171

DOI:

https://doi.org/10.17350/HJSE19030000224

Özet:

 

Isatis L. genus highly endemic and that is traditionally suggested for wound management in Turkey. In this study, we have reported the effect of I. glauca subsp. sivasica extract on diabetic wound healing process. A diabetic model was generated in Wistar rats using streptozotocin injection. Rats were divided into two main groups: control group and Isatis group. Full thickness excisional skin wounds were created by using a biopsy punch. The Isatis group was treated with single daily dose I. glauca subsp. sivasica extract (50 mg/kg). Rats were sacrificed day 3 or 7 after wounding. The dominant phenolic compounds identified with RP-HPLC-DAD from Isatis extract were the benzoic acid and vanillic acid. Isatis extract significantly accelerated wound healing process considering the wound closure rates (WCR). Moreover, the levels of collagen and nitric oxide were elevated on days 3 and 7 by Isatis administration in the diabetic wound tissue. These data suggest that, for the first time, I. glauca subsp. sivasica extract may have the potential to promote the impaired wound healing in patients with diabetes.

Makale detayları

Isatis Glauca Subsp. Sivasica Extract Contributes to Diabetic Wound Healing Process via Increased Collagen and Nitric Oxide Content

Yazarlar: Kaan KALTALIOĞLU | Şule Coşkun CEVHER

Yayıncı: Hitit University

Ana Başlıklar: Astronomi ve ilgili bilimler

Dergi: Hittite Journal of Science and Engineering 2021 Vol.8 Issue 2, pp.141-147

Belge Tipi: Makale

Yayın Tarihi: 6/2021

Belge Dili: İngilizce

Document ID (Org No.): 2000451287

Sıklık: Üç Aylık

eISSN: 2148-4171

DOI: https://doi.org/10.17350/HJSE19030000224

Sayı

Yazarlar:

Kaan KALTALIOĞLU | Şule Coşkun CEVHER

Yayıncı:

Hitit University

Ana Başlıklar:

Astronomi ve ilgili bilimler

Dergi:

Hittite Journal of Science and Engineering 2021 Vol.8 Issue 2, pp.141-147

Belge Tipi:

Makale

Yayın Tarihi:

6/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000451287

Sıklık:

Üç Aylık

eISSN:

2148-4171

DOI:

https://doi.org/10.17350/HJSE19030000224