Synthesis and characterization of new optically active and heat resistant poly(amide-imide)s derived from N,N -(bicyclo[2,2,2]oct-7-ene-2,3,5,6-tetracarboxylic)- bis-L-leucine and aromatic diamines

Negar MOHAMMADHOSSEINI; Ali ASADIPOUR; Bahram LETAFAT

doi:https://doi.org/10.3906/sag-1203-61

Makale detayları

Synthesis and characterization of new optically active and heat resistant poly(amide-imide)s derived from N,N -(bicyclo[2,2,2]oct-7-ene-2,3,5,6-tetracarboxylic)- bis-L-leucine and aromatic diamines

Yazarlar:

Negar MOHAMMADHOSSEINI | Ali ASADIPOUR | Bahram LETAFAT

Yayıncı:

TUBITAK

Ana Başlıklar:

Kimya ve ilgili bilimler

Dergi:

Turkish Journal of Chemistry 2009 Vol.33 Issue 4, pp.459-470

Belge Tipi:

Makale

Yayın Tarihi:

3/2009

Belge Dili:

İngilizce

Document ID (Org No.):

2000728245

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/sag-1203-61

Özet:

 

Starting from (5-nitrofuran-2-yl)methylene diacetate, a new  series of 2-[(substituted  benzyl)thio]-5-(5-nitro-2-furyl)-1,3,4-thiadiazoles (6a-n) were  synthesized and the structures of the compounds were determined using  spectroscopic methods including mass spectrometry, 1H-nuclear  magnetic resonance, infrared spectroscopy, and elemental analysis.  The in vitro anti-Helicobacter pylori activity of the synthesized  compounds was evaluated by the disk diffusion method against the  clinical isolates of Helicobacter pylori.  The results indicated that  most of the synthesized compounds exhibited significant inhibitory  activity against H. pylori with respect to standard drug  metronidazole.  Compound 6l, containing the  2-chloro-6-fluorobenzylthio moiety, was the most potent compound  tested.

 

Starting from (5-nitrofuran-2-yl)methylene diacetate, a new  series of 2-[(substituted  benzyl)thio]-5-(5-nitro-2-furyl)-1,3,4-thiadiazoles (6a-n) were  synthesized and the structures of the compounds were determined using  spectroscopic methods including mass spectrometry, 1H-nuclear  magnetic resonance, infrared spectroscopy, and elemental analysis.  The in vitro anti-Helicobacter pylori activity of the synthesized  compounds was evaluated by the disk diffusion method against the  clinical isolates of Helicobacter pylori.  The results indicated that  most of the synthesized compounds exhibited significant inhibitory  activity against H. pylori with respect to standard drug  metronidazole.  Compound 6l, containing the  2-chloro-6-fluorobenzylthio moiety, was the most potent compound  tested.

Makale detayları

Synthesis and characterization of new optically active and heat resistant poly(amide-imide)s derived from N,N -(bicyclo[2,2,2]oct-7-ene-2,3,5,6-tetracarboxylic)- bis-L-leucine and aromatic diamines

Yazarlar: Negar MOHAMMADHOSSEINI | Ali ASADIPOUR | Bahram LETAFAT

Yayıncı: TUBITAK

Ana Başlıklar: Kimya ve ilgili bilimler

Dergi: Turkish Journal of Chemistry 2009 Vol.33 Issue 4, pp.459-470

Belge Tipi: Makale

Yayın Tarihi: 3/2009

Belge Dili: İngilizce

Document ID (Org No.): 2000728245

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

DOI: https://doi.org/10.3906/sag-1203-61

Sayı

Yazarlar:

Negar MOHAMMADHOSSEINI | Ali ASADIPOUR | Bahram LETAFAT

Yayıncı:

TUBITAK

Ana Başlıklar:

Kimya ve ilgili bilimler

Dergi:

Turkish Journal of Chemistry 2009 Vol.33 Issue 4, pp.459-470

Belge Tipi:

Makale

Yayın Tarihi:

3/2009

Belge Dili:

İngilizce

Document ID (Org No.):

2000728245

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/sag-1203-61