EFFECTS OF DEFIBROTIDE ON STRESS-INDUCED BLADDER MORPHOLOGY

Feriha Ercan; Tangül San; Safiye Çavdar; Oya Karabulut

Makale detayları

EFFECTS OF DEFIBROTIDE ON STRESS-INDUCED BLADDER MORPHOLOGY

Yazarlar:

Feriha Ercan | Tangül San | Safiye Çavdar | Oya Karabulut

Yayıncı:

Marmara University

Dergi:

Marmara Medical Journal 1999 Vol.12 Issue 1, pp.33-38

Belge Tipi:

Makale

Yayın Tarihi:

12/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000546781

Sıklık:

Aylık

eISSN:

1309-9469

pISSN:

1019-1941

Özet:

 


Objective: This study investigates the morphological effect of defibrotide on cold-immobilization stress- induced rat urinary bladder.Material and Methods: Wistar albino rats were used in this study. After the cold, immobilization stress following the 48 hours of fasting, defibrotide was applied either intraperitonally (16 mg/ml) or intravesically (1200pg/ml). Urinary bladders were removed for light and electron microscopical investigations.Results: The stress group showed leukocyte infiltration and edema, further vacuoles in the cytoplasm of urothelial cells and loose tight junctions. Additionally, urothelial protrusions towards the lumen were observed. The defibrotide-applied groups displayed regular morphology both under light and electron microscopy level.Conclusion: These results showed that defibrotide reverse the stress induced morphological alterations. Although the biochemical effects of defibrotide is unknown, a possible explanation could be via modulation of calcium entry into the cells, and increase the permeability and regulation of inflammatory response and/or may have a role in the protection of urothelium by increasing the synthesis of prostaglandins and have a cytoprotective role in stress-induced bladder damage.Key Words: Defibrotide, cytoprotection, cold- immobilization stress, urinary bladder, ultrastructure

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Makale detayları

EFFECTS OF DEFIBROTIDE ON STRESS-INDUCED BLADDER MORPHOLOGY

Yazarlar: Feriha Ercan | Tangül San | Safiye Çavdar | Oya Karabulut

Yayıncı: Marmara University

Dergi: Marmara Medical Journal 1999 Vol.12 Issue 1, pp.33-38

Belge Tipi: Makale

Yayın Tarihi: 12/2016

Belge Dili: Türkçe

Document ID (Org No.): 2000546781

Sıklık: Aylık

eISSN: 1309-9469

pISSN: 1019-1941

Sayı

Yazarlar:

Feriha Ercan | Tangül San | Safiye Çavdar | Oya Karabulut

Yayıncı:

Marmara University

Dergi:

Marmara Medical Journal 1999 Vol.12 Issue 1, pp.33-38

Belge Tipi:

Makale

Yayın Tarihi:

12/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000546781

Sıklık:

Aylık

eISSN:

1309-9469

pISSN:

1019-1941