Ecofriendly one-pot synthesis and antiviral evaluation of novel pyrazolyl   pyrazolines of medicinal interest

Sobhi GOMHA; Magda ABDALLA; Mohamad  Abd EL-AZIZ; Nany SERAG

Makale detayları

Ecofriendly one-pot synthesis and antiviral evaluation of novel pyrazolyl pyrazolines of medicinal interest

Yazarlar:

Sobhi GOMHA | Magda ABDALLA | Mohamad Abd EL-AZIZ | Nany SERAG

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2016 Vol.40 Issue 3, pp.484-498

Belge Tipi:

Makale

Yayın Tarihi:

5/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000726625

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

Ethyl 3-acetyl-1,5-diphenyl-1HHH-pyrazole-4-carboxylate reacts with a variety of arylaldehydes by grinding method in the presence of a catalytic amount of sodium hydroxide at ambient temperature to give the respective chalcones. The latter compounds react also by grinding method with nitrogen nucleophiles such as hydrazine hydrate, phenylhydrazine, and thiosemicarbazide to afford the corresponding pyrazol-3-yl pyrazolines. A   series of 6-pyrazolylpyrimidine-2-thione derivatives were prepared by   reaction of the above chalcones with thiourea by grinding method in the   presence of a catalytic amount of sodium hydroxide at room temperature. In   addition, 7-pyrazolylpyridopyrimidine-3-thione was prepared by reaction of   chalcone with 6-aminothiouracil. All the newly synthesized compounds were   characterized on the basis of elemental analysis and spectral data (IR,   11^{1}H and 1313^{13}C NMR, mass). Moreover, some of the products were   evaluated for their antiviral activity against the herpes virus at different   concentrations. The results obtained indicated that compounds 4a,   4b, 4f, 5a, 5b, and 5c have   promising activity.

Makale detayları

Ecofriendly one-pot synthesis and antiviral evaluation of novel pyrazolyl pyrazolines of medicinal interest

Yazarlar: Sobhi GOMHA | Magda ABDALLA | Mohamad Abd EL-AZIZ | Nany SERAG

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2016 Vol.40 Issue 3, pp.484-498

Belge Tipi: Makale

Yayın Tarihi: 5/2016

Belge Dili: Türkçe

Document ID (Org No.): 2000726625

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Sobhi GOMHA | Magda ABDALLA | Mohamad Abd EL-AZIZ | Nany SERAG

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2016 Vol.40 Issue 3, pp.484-498

Belge Tipi:

Makale

Yayın Tarihi:

5/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000726625

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527