Invasive Candida Infections in Children: Species Distribution, Antifungal Susceptibility, and Risk Factors Associated with Mortality

Nurşen Belet; Ahmet Naci Emecen

Makale detayları

Invasive Candida Infections in Children: Species Distribution, Antifungal Susceptibility, and Risk Factors Associated with Mortality

Yazarlar:

Nurşen Belet | Ahmet Naci Emecen

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Public Health (Other)

Dergi:

Meandros Medical And Dental Journal Vol.24 Issue 1, pp.78-84

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001348379

pISSN:

2149-9063

Anahtar kelimeler:

Özet:

 Objective: This study determined the distribution and antifungal susceptibility of Candida species, risk factors, and mortality in invasive candidiasis IC. Materials and Methods: The medical data of the pediatric patients with IC were analyzed retrospectively between September 2014 and September 2018. The first IC episodes were included, and the susceptibility was determined by the microdilution method performed according to The Clinical and Laboratory Standards Institute M27-A3 standards. Kaplan-Meier curves were prepared for survival on the 7th and 30th day after the first positive culture and the curves were compared with the log-rank test. Results: Forty-eight Candida isolates were detected in 45 IC episodes. C. albicans and C. parapsilosis were the most common species both 41.7. Fluconazole, caspofungin, and amphotericin B resistance were 38.2, 3.1, and 2.9, respectively. Fluconazole resistance was 73.3 among C. parapsilosis. The most common risk factors were underlying diseases 100, previous antibiotic use 95.6, and central venous catheter 73.3. Six 13.3 patients were deceased within the 30 days. Patients with neutropenia and dialysis had a higher rate of mortality and lower mean survival times for 7-day and 30-day mortality. Mean survival times for 7-day mortality were lower for the patients who had abdominal surgery p0.04. Conclusions: There was high fluconazole resistance in C. parapsilosis, which was 73.3. Neutropenia, dialysis, and abdominal surgery were associated with a significant increase in mortality. These data will help us identify patients who are at risk for IC and will guide us in the selection of empirical treatment.

 Objective: This study determined the distribution and antifungal susceptibility of Candida species, risk factors, and mortality in invasive candidiasis IC. Materials and Methods: The medical data of the pediatric patients with IC were analyzed retrospectively between September 2014 and September 2018. The first IC episodes were included, and the susceptibility was determined by the microdilution method performed according to The Clinical and Laboratory Standards Institute M27-A3 standards. Kaplan-Meier curves were prepared for survival on the 7th and 30th day after the first positive culture and the curves were compared with the log-rank test. Results: Forty-eight Candida isolates were detected in 45 IC episodes. C. albicans and C. parapsilosis were the most common species both 41.7. Fluconazole, caspofungin, and amphotericin B resistance were 38.2, 3.1, and 2.9, respectively. Fluconazole resistance was 73.3 among C. parapsilosis. The most common risk factors were underlying diseases 100, previous antibiotic use 95.6, and central venous catheter 73.3. Six 13.3 patients were deceased within the 30 days. Patients with neutropenia and dialysis had a higher rate of mortality and lower mean survival times for 7-day and 30-day mortality. Mean survival times for 7-day mortality were lower for the patients who had abdominal surgery p0.04. Conclusions: There was high fluconazole resistance in C. parapsilosis, which was 73.3. Neutropenia, dialysis, and abdominal surgery were associated with a significant increase in mortality. These data will help us identify patients who are at risk for IC and will guide us in the selection of empirical treatment.

 Objective: This study determined the distribution and antifungal susceptibility of Candida species, risk factors, and mortality in invasive candidiasis IC. Materials and Methods: The medical data of the pediatric patients with IC were analyzed retrospectively between September 2014 and September 2018. The first IC episodes were included, and the susceptibility was determined by the microdilution method performed according to The Clinical and Laboratory Standards Institute M27-A3 standards. Kaplan-Meier curves were prepared for survival on the 7th and 30th day after the first positive culture and the curves were compared with the log-rank test. Results: Forty-eight Candida isolates were detected in 45 IC episodes. C. albicans and C. parapsilosis were the most common species both 41.7. Fluconazole, caspofungin, and amphotericin B resistance were 38.2, 3.1, and 2.9, respectively. Fluconazole resistance was 73.3 among C. parapsilosis. The most common risk factors were underlying diseases 100, previous antibiotic use 95.6, and central venous catheter 73.3. Six 13.3 patients were deceased within the 30 days. Patients with neutropenia and dialysis had a higher rate of mortality and lower mean survival times for 7-day and 30-day mortality. Mean survival times for 7-day mortality were lower for the patients who had abdominal surgery p0.04. Conclusions: There was high fluconazole resistance in C. parapsilosis, which was 73.3. Neutropenia, dialysis, and abdominal surgery were associated with a significant increase in mortality. These data will help us identify patients who are at risk for IC and will guide us in the selection of empirical treatment.

 Objective: This study determined the distribution and antifungal susceptibility of Candida species, risk factors, and mortality in invasive candidiasis IC. Materials and Methods: The medical data of the pediatric patients with IC were analyzed retrospectively between September 2014 and September 2018. The first IC episodes were included, and the susceptibility was determined by the microdilution method performed according to The Clinical and Laboratory Standards Institute M27-A3 standards. Kaplan-Meier curves were prepared for survival on the 7th and 30th day after the first positive culture and the curves were compared with the log-rank test. Results: Forty-eight Candida isolates were detected in 45 IC episodes. C. albicans and C. parapsilosis were the most common species both 41.7. Fluconazole, caspofungin, and amphotericin B resistance were 38.2, 3.1, and 2.9, respectively. Fluconazole resistance was 73.3 among C. parapsilosis. The most common risk factors were underlying diseases 100, previous antibiotic use 95.6, and central venous catheter 73.3. Six 13.3 patients were deceased within the 30 days. Patients with neutropenia and dialysis had a higher rate of mortality and lower mean survival times for 7-day and 30-day mortality. Mean survival times for 7-day mortality were lower for the patients who had abdominal surgery p0.04. Conclusions: There was high fluconazole resistance in C. parapsilosis, which was 73.3. Neutropenia, dialysis, and abdominal surgery were associated with a significant increase in mortality. These data will help us identify patients who are at risk for IC and will guide us in the selection of empirical treatment.

Makale detayları

Invasive Candida Infections in Children: Species Distribution, Antifungal Susceptibility, and Risk Factors Associated with Mortality

Yazarlar:

Nurşen Belet | Ahmet Naci Emecen

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Public Health (Other)

Dergi:

Meandros Medical And Dental Journal Vol.24 Issue 1, pp.78-84

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001348379

pISSN:

2149-9063

Antifungal susceptibility

amphotericin B

candidaemia

Candida spp.

fluconazole resistance

pediatric

Sayı

Makale detayları

Invasive Candida Infections in Children: Species Distribution, Antifungal Susceptibility, and Risk Factors Associated with Mortality

Yazarlar: Nurşen Belet | Ahmet Naci Emecen

Yayıncı: Aydin Adnan Menderes University

Ana Başlıklar: Public Health (Other)

Dergi: Meandros Medical And Dental Journal Vol.24 Issue 1, pp.78-84

Belge Tipi: Makale

Yayın Tarihi: 3/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001348379

pISSN: 2149-9063

Antifungal susceptibility

amphotericin B

candidaemia

Candida spp.

fluconazole resistance

pediatric

Sayı

Yazarlar:

Nurşen Belet | Ahmet Naci Emecen

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Public Health (Other)

Dergi:

Meandros Medical And Dental Journal Vol.24 Issue 1, pp.78-84

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001348379

pISSN:

2149-9063