THE ROLE OF INFLAMMATORY PARAMETERS AND SCORING SYSTEMS IN PREDICTING COMPLICATED ACUTE APPENDICITIS

Mehmet Gökhan Kaya; Ethem Acar

Makale detayları

THE ROLE OF INFLAMMATORY PARAMETERS AND SCORING SYSTEMS IN PREDICTING COMPLICATED ACUTE APPENDICITIS

Yazarlar:

Mehmet Gökhan Kaya | Ethem Acar

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Emergency Medicine

Dergi:

Meandros Medical And Dental Journal Vol.25 Issue 3, pp.305-316

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001327318

pISSN:

2149-9063

Anahtar kelimeler:

Özet:

 Aim: To assess the complications associated with acute appendicitis AA and to evaluate how specific routine patient parameters influence disease severity. Materials and Methods: A retrospective study was carried out on patients diagnosed with AA who presented to the emergency department ED between January 1, 2019, and December 31, 2020. Data collected included demographic details, blood test results, and specific scoring systems utilized in the ED. Results: Of the 223 patients studied, 63.7 were male with a mean age of 37.5  16.8 years. Patients with complicated appendicitis CA showed significantly elevated hematological parameters such as neutrophil-to-lymphocyte ratio NLR, platelet-to-lymphocyte ratio PLR, C-reactive protein CRP, systemic immune inflammation index SII, white blood cell count WBC, and neutrophil levels. Conversely, decreased lymphocyteC-reactive protein ratio LCRP and lymphocyte levels were noted. Furthermore, CA cases exhibited significantly greater Appendicitis Inflammatory Response AIR and Alvarado scores. In the context of diagnosing CA, the AIR score had a sensitivity of 85.9 and a specificity of 47.9 with a cut-off value of 6 95 CI 0.675-0.821, Area Under the Curve AUC: 0.748; p0.01. The Alvarado score showed a sensitivity of 80.6 and a specificity of 44.5, using a cut-off value of 6 95 CI 0.527-0.683, AUC: 0.605; p0.10. Conclusion: Our study determined that inflammatory markers such as LCRP, SII, NLR, and PLR serve as significant indicators for distinguishing between CA and its NCA.

 Aim: To assess the complications associated with acute appendicitis AA and to evaluate how specific routine patient parameters influence disease severity. Materials and Methods: A retrospective study was carried out on patients diagnosed with AA who presented to the emergency department ED between January 1, 2019, and December 31, 2020. Data collected included demographic details, blood test results, and specific scoring systems utilized in the ED. Results: Of the 223 patients studied, 63.7 were male with a mean age of 37.5  16.8 years. Patients with complicated appendicitis CA showed significantly elevated hematological parameters such as neutrophil-to-lymphocyte ratio NLR, platelet-to-lymphocyte ratio PLR, C-reactive protein CRP, systemic immune inflammation index SII, white blood cell count WBC, and neutrophil levels. Conversely, decreased lymphocyteC-reactive protein ratio LCRP and lymphocyte levels were noted. Furthermore, CA cases exhibited significantly greater Appendicitis Inflammatory Response AIR and Alvarado scores. In the context of diagnosing CA, the AIR score had a sensitivity of 85.9 and a specificity of 47.9 with a cut-off value of 6 95 CI 0.675-0.821, Area Under the Curve AUC: 0.748; p0.01. The Alvarado score showed a sensitivity of 80.6 and a specificity of 44.5, using a cut-off value of 6 95 CI 0.527-0.683, AUC: 0.605; p0.10. Conclusion: Our study determined that inflammatory markers such as LCRP, SII, NLR, and PLR serve as significant indicators for distinguishing between CA and its NCA.

 Aim: To assess the complications associated with acute appendicitis AA and to evaluate how specific routine patient parameters influence disease severity. Materials and Methods: A retrospective study was carried out on patients diagnosed with AA who presented to the emergency department ED between January 1, 2019, and December 31, 2020. Data collected included demographic details, blood test results, and specific scoring systems utilized in the ED. Results: Of the 223 patients studied, 63.7 were male with a mean age of 37.5  16.8 years. Patients with complicated appendicitis CA showed significantly elevated hematological parameters such as neutrophil-to-lymphocyte ratio NLR, platelet-to-lymphocyte ratio PLR, C-reactive protein CRP, systemic immune inflammation index SII, white blood cell count WBC, and neutrophil levels. Conversely, decreased lymphocyteC-reactive protein ratio LCRP and lymphocyte levels were noted. Furthermore, CA cases exhibited significantly greater Appendicitis Inflammatory Response AIR and Alvarado scores. In the context of diagnosing CA, the AIR score had a sensitivity of 85.9 and a specificity of 47.9 with a cut-off value of 6 95 CI 0.675-0.821, Area Under the Curve AUC: 0.748; p0.01. The Alvarado score showed a sensitivity of 80.6 and a specificity of 44.5, using a cut-off value of 6 95 CI 0.527-0.683, AUC: 0.605; p0.10. Conclusion: Our study determined that inflammatory markers such as LCRP, SII, NLR, and PLR serve as significant indicators for distinguishing between CA and its NCA.

 Amaç: Akut apandisit tanısı alan hastaların rutin parametrelerini değerlendirilerek, hastaların komplikasyon durumunu ve bu parametrelerin hastalığın ciddiyeti üzerindeki etkilerini tespit etmeyi amaçlanmıştır. Gereç ve Yöntem: Bu çalışma, acil serviste AS 1 Ocak 2019 ve 31 Aralık 2020 tarihleri arasında akut apandisit AA tanısı alan hastaların araştırıldığı retrospektif bir çalışmadır. Hastaların demografik verileri, kan tetkikleri, ASde hesaplanan skorları kayıt altına alınmıştır. Bulgular: Çalışmaya dâhil edilen 223 hastanın 63,7si erkek olup yaş ortalaması 37.5  16.8 yıl olarak hesaplanmıştır. Komplike apandisit KA olgularının hematolojik parametreler açısından istatistiksel olarak anlamlı düzeyde daha yüksek nötrofil  lenfosit oranı NLR, platelet  lenfosit oranı PLR, C-reaktif protein CRP, sistemik immun inflamasyon indeksi SII, beyaz kan hücresi WBC, nötrofil düzeylerine sahip olduğu bulunmuş; buna karşın lenfosit  C-reaktif protein oranı LCRP ve lenfosit düşüklüğü tespit edilmiştir. Ayrıca KA olgularının istatistiksel olarak anlamlı düzeyde daha yüksek Apandisit İnflamatuar Yanıt AIR ve Alvarado skorlarına sahip oldukları tespit edilmiştir. KA tespit etmede AIR ve Alvarado skorları, LCRP ve NLR paramatrelerinin sensivite ve spesifiteleri incelendiğinde; AIR skoru için sırasıyla 85,9, 47,9 kesme 6, 95 CI, 0.675-0.821, AUC: 0.748; p0,01, Alvarado skoru için sırasıyla 80,6, 44,5 kesme 6, 95 Cl, 0,527-0,683, AUC 0,605; p:0,10, olarak bulunmuştur. Sonuç: İnflamatuvar belirteçlerin, KA  Non- komplike apandisit NKA ayrımında önemli parametreler olduğu tespit edilmiştir. Çalışmada; LCRP, SII, NLR, PLR gibi değerlerin, KA  NKA ayrımında kullanışlı parametreler olarak bulunmuştur.

Makale detayları

THE ROLE OF INFLAMMATORY PARAMETERS AND SCORING SYSTEMS IN PREDICTING COMPLICATED ACUTE APPENDICITIS

Yazarlar:

Mehmet Gökhan Kaya | Ethem Acar

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Emergency Medicine

Dergi:

Meandros Medical And Dental Journal Vol.25 Issue 3, pp.305-316

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001327318

pISSN:

2149-9063

Acute appendicitis

Appendicitis inflammatory response score

Alvarado score

Emergency department

Complicated appendicitis

Non-complicated appendicitisAkut apandisit

Apandisit inflamatuvar yanıt skoru

Alvarado skoru

Acil servis

Komplike apandisit

Non-komplike apandisit

Sayı

Makale detayları

Yazarlar: Mehmet Gökhan Kaya | Ethem Acar

Yayıncı: Aydin Adnan Menderes University

Ana Başlıklar: Emergency Medicine

Dergi: Meandros Medical And Dental Journal Vol.25 Issue 3, pp.305-316

Belge Tipi: Makale

Yayın Tarihi: 9/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001327318

pISSN: 2149-9063

Sayı

Yazarlar:

Mehmet Gökhan Kaya | Ethem Acar

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Emergency Medicine

Dergi:

Meandros Medical And Dental Journal Vol.25 Issue 3, pp.305-316

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001327318

pISSN:

2149-9063