QUALITY CONTROL STUDIES ON SOME SESAME OIL SAMPLES SOLD IN PHARMACIES AND HERBALISTS

Halilibrahim Aykut Şahin; Gülen İrem Kaya

Makale detayları

QUALITY CONTROL STUDIES ON SOME SESAME OIL SAMPLES SOLD IN PHARMACIES AND HERBALISTS

Yazarlar:

Halilibrahim Aykut Şahin | Gülen İrem Kaya

Yayıncı:

Ankara University

Ana Başlıklar:

Farmakognozi

Dergi:

Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.49 Issue 1, pp.71-78

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001333041

pISSN:

1015-3918

Anahtar kelimeler:

Özet:

 Objective: Fixed oils; are mixtures obtained from natural sources and cause various physiological effects internally and externally in the body. Depending on the plant from which they are obtained, fixed oils contain substances such as free fatty acids, their glycerol esters, aromatic compounds, phenolic compounds, phytosterols, and vitamins. It is not always possible to obtain accurate information about the source and quality of fixed oils sold in the market. Fixed oils of pharmacopoeial quality should be preferred as therapeutic agents in phytotherapy and as carrier oils in aromatherapy. Sesame oil, one of these fixed oils, is used internally in phytotherapy to treat constipation, especially dyschezia, while externally it is used as a massage oil in rheumatic pain and as an emollient in dry skin diseases. Due to these activities and its use in phytotherapy; it is aimed to evaluate the compliance of some sesame oil samples sold in pharmacies and herbalists with the Turkish Pharmacopoeia 2017. Material and Method: In this study, on 6 different commercial sesame oil samples sold in pharmacies and herbalists, acidity, peroxide number, unsaponifiable substance values, relative density and refractive index determinations were made. Alkaline impurities and cottonseed oil search tests as foreign oil were also carried out which are amongst the Turkish Pharmacopoeia 2017 monograph on sesame oil in our study. In addition, sesame oil samples were compared with different oil samples using the Thin Layer Chromatography TLC method Result and Discussion: According to the data obtained as a result of pharmacopoeia analyzes carried out on samples; It was recorded that 2 of the analyzed sesame oil samples comply with all quality values specified in the pharmacopoeia. No alkaline impurities and cottonseed oil were detected in any oil samples. In the study, conducted using TLC, it was concluded that one oil sample may have been adulterated with a different oil. As an example, the results of the pharmacopoeial analysis of the sesame oils have revealed that many sesame oils available in the market are not of pharmacopoeial quality.

 Objective: Fixed oils; are mixtures obtained from natural sources and cause various physiological effects internally and externally in the body. Depending on the plant from which they are obtained, fixed oils contain substances such as free fatty acids, their glycerol esters, aromatic compounds, phenolic compounds, phytosterols, and vitamins. It is not always possible to obtain accurate information about the source and quality of fixed oils sold in the market. Fixed oils of pharmacopoeial quality should be preferred as therapeutic agents in phytotherapy and as carrier oils in aromatherapy. Sesame oil, one of these fixed oils, is used internally in phytotherapy to treat constipation, especially dyschezia, while externally it is used as a massage oil in rheumatic pain and as an emollient in dry skin diseases. Due to these activities and its use in phytotherapy; it is aimed to evaluate the compliance of some sesame oil samples sold in pharmacies and herbalists with the Turkish Pharmacopoeia 2017. Material and Method: In this study, on 6 different commercial sesame oil samples sold in pharmacies and herbalists, acidity, peroxide number, unsaponifiable substance values, relative density and refractive index determinations were made. Alkaline impurities and cottonseed oil search tests as foreign oil were also carried out which are amongst the Turkish Pharmacopoeia 2017 monograph on sesame oil in our study. In addition, sesame oil samples were compared with different oil samples using the Thin Layer Chromatography TLC method Result and Discussion: According to the data obtained as a result of pharmacopoeia analyzes carried out on samples; It was recorded that 2 of the analyzed sesame oil samples comply with all quality values specified in the pharmacopoeia. No alkaline impurities and cottonseed oil were detected in any oil samples. In the study, conducted using TLC, it was concluded that one oil sample may have been adulterated with a different oil. As an example, the results of the pharmacopoeial analysis of the sesame oils have revealed that many sesame oils available in the market are not of pharmacopoeial quality.

 Objective: Fixed oils; are mixtures obtained from natural sources and cause various physiological effects internally and externally in the body. Depending on the plant from which they are obtained, fixed oils contain substances such as free fatty acids, their glycerol esters, aromatic compounds, phenolic compounds, phytosterols, and vitamins. It is not always possible to obtain accurate information about the source and quality of fixed oils sold in the market. Fixed oils of pharmacopoeial quality should be preferred as therapeutic agents in phytotherapy and as carrier oils in aromatherapy. Sesame oil, one of these fixed oils, is used internally in phytotherapy to treat constipation, especially dyschezia, while externally it is used as a massage oil in rheumatic pain and as an emollient in dry skin diseases. Due to these activities and its use in phytotherapy; it is aimed to evaluate the compliance of some sesame oil samples sold in pharmacies and herbalists with the Turkish Pharmacopoeia 2017. Material and Method: In this study, on 6 different commercial sesame oil samples sold in pharmacies and herbalists, acidity, peroxide number, unsaponifiable substance values, relative density and refractive index determinations were made. Alkaline impurities and cottonseed oil search tests as foreign oil were also carried out which are amongst the Turkish Pharmacopoeia 2017 monograph on sesame oil in our study. In addition, sesame oil samples were compared with different oil samples using the Thin Layer Chromatography TLC method Result and Discussion: According to the data obtained as a result of pharmacopoeia analyzes carried out on samples; It was recorded that 2 of the analyzed sesame oil samples comply with all quality values specified in the pharmacopoeia. No alkaline impurities and cottonseed oil were detected in any oil samples. In the study, conducted using TLC, it was concluded that one oil sample may have been adulterated with a different oil. As an example, the results of the pharmacopoeial analysis of the sesame oils have revealed that many sesame oils available in the market are not of pharmacopoeial quality.

 Amaç: Sabit yağlar; doğal kaynaklardan elde edilen ve vücutta dahilen ve haricen çeşitli fizyolojik etkilere sebep olan karışımlardır. Sabit yağlar elde edildiği bitkiye bağlı olarak serbest yağ asitleri, bunların gliserol esterlerini, aromatik bileşikler, fenolik bileşikler, fitosteroller ve vitaminler gibi bileşenleri içerirler. Piyasada satılan sabit yağların kaynağına ve kalitesine dair doğru bilgiye ulaşmak her zaman mümkün olmamaktadır. Fitoterapide terapötik ajan olarak ve aromaterapide taşıyıcı yağ olarak, farmakope kalitesinde olan sabit yağlar tercih edilmelidir. Sabit yağlardan biri olan susam yağı fitoterapide dahilen kabızlık, özellikle de diskezi tedavisinde kullanılırken, haricen romatizmal ağrılarda masaj yağı olarak ve cilt kuruluğuna bağlı rahatsızlıklarda yumuşatıcı olarak kullanılmaktadır. Bu çalışmamızda etkileri ve fitoterapide kullanımlarından yola çıkılarak, eczane ve aktarlarda satılan bazı susam yağı örneklerinin Türk Farmakopesi 2017ye uygunluğunun değerlendirilmesi hedeflenmiştir. Gereç ve Yöntem: Bu çalışmada eczane ve aktarlarda satılan 6 farklı ticari susam yağ örneği üzerinde Türk Farmakopesi 2017de susam yağı için belirtilen; genel özelliklerden, asit değeri, peroksit sayısı,  sabunlaşmayan madde miktarı, bağıl yoğunluk ve kırılım imleci tayinleri yapılmıştır. Çalışmamızda ayrıca yağın içindeki alkali safsızlıklar ve yabancı yağ olarak pamuk tohumu yağı arama testleri yürütülmüştür. Bunun yanında susam yağı örnekleri ile farklı yağ örnekleri ince tabaka kromatografisi İTK yöntemiyle karşılaştırılmıştır. Sonuç ve Tartışma: Piyasadan temin edilen numunelerle yapılan farmakope analizleri sonucunda elde edilen veriler ışığında; analizi yapılan susam yağı örneklerinden 2 tanesinin farmakopede belirtilen bütün kalite değerlerine uyduğu görülmektedir. Hiçbir yağ örneğinde alkali safsızlık ve pamuk tohumu yağı tespit edilmemiştir. İTK ile yapılan çalışmada bir susam yağı örneğinin farklı bir yağ ile karıştırılmış olabileceği sonucuna varılmıştır. Örnek olarak temin edilip çalışılan susam yağlarının yapılan farmakope analizleri sonuçları, piyasadaki pek çok susam yağının farmakope kalitesinde olmadığını ortaya konmuştur.

Makale detayları

QUALITY CONTROL STUDIES ON SOME SESAME OIL SAMPLES SOLD IN PHARMACIES AND HERBALISTS

Yazarlar:

Halilibrahim Aykut Şahin | Gülen İrem Kaya

Yayıncı:

Ankara University

Ana Başlıklar:

Farmakognozi

Dergi:

Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.49 Issue 1, pp.71-78

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001333041

pISSN:

1015-3918

Fixed oil

pharmacopoeia analysis

phytotherapy

Turkish PharmacopoeiaFarmakope analizi

fitoterapi

sabit yağ

Türk Farmakopesi

Sayı

Makale detayları

Yazarlar: Halilibrahim Aykut Şahin | Gülen İrem Kaya

Yayıncı: Ankara University

Ana Başlıklar: Farmakognozi

Dergi: Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.49 Issue 1, pp.71-78

Belge Tipi: Makale

Yayın Tarihi: 1/2025

Belge Dili: Türkçe

Document ID (Org No.): 2001333041

pISSN: 1015-3918

Sayı

Yazarlar:

Halilibrahim Aykut Şahin | Gülen İrem Kaya

Yayıncı:

Ankara University

Ana Başlıklar:

Farmakognozi

Dergi:

Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.49 Issue 1, pp.71-78

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001333041

pISSN:

1015-3918