Association of Insulin Resistance and Ectopic Fat Accumulation with HOMA Indices: A Single-Centre Observational Study

Sevde Nur Emir; Servet Emir

Makale detayları

Association of Insulin Resistance and Ectopic Fat Accumulation with HOMA Indices: A Single-Centre Observational Study

Yazarlar:

Sevde Nur Emir | Servet Emir

Yayıncı:

Zonguldak Bulent Ecevit University

Ana Başlıklar:

Radyoloji ve Organ Görüntüleme

Dergi:

Türkiye Diyabet ve Obezite Dergisi Vol.8 Issue 2, pp.97-106

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001326123

pISSN:

2587-0335

Anahtar kelimeler:

Özet:

 Purpose: The aim of this study was to investigate the relationship between non-alcoholic fatty liver disease NAFLD, non-alcoholic fatty pancreas or pancreatic disease NAFPD and HOMA indices in obese patients without a diagnosis of diabetes mellitus, using ultrasound US as a common non-invasive diagnostic tool during routine examinations. Methods: In this single-centre, retrospective study, the records of patients who applied to the obesity outpatient clinic in 2023 were reviewed. Digital records were scanned and patients with abdominal ultrasound reports indicating age, gender, body mass indexBMI, fasting plasma glucose, fasting plasma glucose, C-peptide level and degree of pancreatic and hepatic steatosis were included in the study. Patients with known chronic disease or diabetes mellitus and patients with specific drug use were excluded from the study. Homa indices were calculated using fasting plasma glucose and C-peptide levels. Results: A total of 62 patients were included. Body mass index was 39.1, 91 had NAFLD and 82 had NAFPD. There was a significant positive correlation between BMI and NAFLD and NAFPD. HOMA scores revealed a statistically significant impact of NAFLD on insulin resistance HOMA-IR and insulin sensitivity HOMA-S but not on beta-cell function HOMA-B. No significant effect of NAFPD on HOMA scores was observed. Conclusion: The findings underline the association between NAFLD and insulin resistance and highlight the metabolic burden of ectopic fat deposition in obese patients. In contrast, there was no significant correlation between NAFPD and either insulin resistance or beta-cell function, suggesting that the metabolic impact of pancreatic steatosis may be different. These findings may help to guide clinical strategies for detecting and treating metabolic disorders in obesity.

 Purpose: The aim of this study was to investigate the relationship between non-alcoholic fatty liver disease NAFLD, non-alcoholic fatty pancreas or pancreatic disease NAFPD and HOMA indices in obese patients without a diagnosis of diabetes mellitus, using ultrasound US as a common non-invasive diagnostic tool during routine examinations. Methods: In this single-centre, retrospective study, the records of patients who applied to the obesity outpatient clinic in 2023 were reviewed. Digital records were scanned and patients with abdominal ultrasound reports indicating age, gender, body mass indexBMI, fasting plasma glucose, fasting plasma glucose, C-peptide level and degree of pancreatic and hepatic steatosis were included in the study. Patients with known chronic disease or diabetes mellitus and patients with specific drug use were excluded from the study. Homa indices were calculated using fasting plasma glucose and C-peptide levels. Results: A total of 62 patients were included. Body mass index was 39.1, 91 had NAFLD and 82 had NAFPD. There was a significant positive correlation between BMI and NAFLD and NAFPD. HOMA scores revealed a statistically significant impact of NAFLD on insulin resistance HOMA-IR and insulin sensitivity HOMA-S but not on beta-cell function HOMA-B. No significant effect of NAFPD on HOMA scores was observed. Conclusion: The findings underline the association between NAFLD and insulin resistance and highlight the metabolic burden of ectopic fat deposition in obese patients. In contrast, there was no significant correlation between NAFPD and either insulin resistance or beta-cell function, suggesting that the metabolic impact of pancreatic steatosis may be different. These findings may help to guide clinical strategies for detecting and treating metabolic disorders in obesity.

 Purpose: The aim of this study was to investigate the relationship between non-alcoholic fatty liver disease NAFLD, non-alcoholic fatty pancreas or pancreatic disease NAFPD and HOMA indices in obese patients without a diagnosis of diabetes mellitus, using ultrasound US as a common non-invasive diagnostic tool during routine examinations. Methods: In this single-centre, retrospective study, the records of patients who applied to the obesity outpatient clinic in 2023 were reviewed. Digital records were scanned and patients with abdominal ultrasound reports indicating age, gender, body mass indexBMI, fasting plasma glucose, fasting plasma glucose, C-peptide level and degree of pancreatic and hepatic steatosis were included in the study. Patients with known chronic disease or diabetes mellitus and patients with specific drug use were excluded from the study. Homa indices were calculated using fasting plasma glucose and C-peptide levels. Results: A total of 62 patients were included. Body mass index was 39.1, 91 had NAFLD and 82 had NAFPD. There was a significant positive correlation between BMI and NAFLD and NAFPD. HOMA scores revealed a statistically significant impact of NAFLD on insulin resistance HOMA-IR and insulin sensitivity HOMA-S but not on beta-cell function HOMA-B. No significant effect of NAFPD on HOMA scores was observed. Conclusion: The findings underline the association between NAFLD and insulin resistance and highlight the metabolic burden of ectopic fat deposition in obese patients. In contrast, there was no significant correlation between NAFPD and either insulin resistance or beta-cell function, suggesting that the metabolic impact of pancreatic steatosis may be different. These findings may help to guide clinical strategies for detecting and treating metabolic disorders in obesity.

 Amaç: Bu çalışmanın amacı, diyabet mellitus tanısı olmayan obez hastalarda, rutin muayeneler sırasında yaygın bir non-invaziv tanı aracı olan ultrason US kullanılarak, non alkolik yağlı karaciğer hastalığı NAFLD, non alkolik yağlı pankreas veya pankreatik hastalığı NAFPD ve HOMA indeksleri arasındaki ilişkiyi araştırmaktır. Yöntemler: Bu tek merkezli, retrospektif çalışmada, 2023 yılında obezite polikliniğine başvuran hastaların kayıtları gözden geçirilmiştir. Dijital kayıtlar taranmış ve yaş, cinsiyet, vücut kitle indeksi VKİ, açlık plazma glikozu, açlık plazma glikozu, C-peptid seviyesi ve pankreatik ve hepatik steatoz derecesini belirten abdominal ultrason raporlarına sahip hastalar çalışmaya dahil edilmiştir. Bilinen kronik hastalığı veya diyabet mellitusu olan ve belirli ilaçları kullanan hastalar çalışma dışı bırakılmıştır. Homa indeksleri, açlık plazma glikozu ve C-peptid seviyeleri kullanılarak hesaplanmıştır. Sonuçlar: Toplam 62 hasta dahil edilmiştir. Ortalama vücut kitle indeksi 39.1, 91inde NAFLD ve 82sinde NAFPD bulunmuştur. VKİ ile NAFLD ve NAFPD arasında anlamlı pozitif bir korelasyon saptanmıştır. HOMA skorları, NAFLDnin insülin direnci HOMA-IR ve insülin hassasiyeti HOMA-S üzerinde istatistiksel olarak anlamlı bir etkisi olduğunu, ancak beta-hücre fonksiyonu HOMA-B üzerinde anlamlı bir etkisinin olmadığını ortaya koymuştur. NAFPDnin HOMA skorları üzerinde anlamlı bir etkisi gözlenmemiştir. Sonuç: Bulgular, NAFLD ile insülin direnci arasındaki ilişkiyi vurgulamakta ve obez hastalarda ektopik yağ birikiminin metabolik yükünü ön plana çıkarmaktadır. Buna karşın, NAFPD ile insülin direnci veya beta-hücre fonksiyonu arasında anlamlı bir korelasyon bulunmamıştır, bu da pankreatik steatozun metabolik etkisinin farklı olabileceğini öne sürmektedir. Bu bulgular, obezitede metabolik bozuklukların tespiti ve tedavisi için klinik stratejileri yönlendirmede yardımcı olabilir.

Makale detayları

Association of Insulin Resistance and Ectopic Fat Accumulation with HOMA Indices: A Single-Centre Observational Study

Yazarlar:

Sevde Nur Emir | Servet Emir

Yayıncı:

Zonguldak Bulent Ecevit University

Ana Başlıklar:

Radyoloji ve Organ Görüntüleme

Dergi:

Türkiye Diyabet ve Obezite Dergisi Vol.8 Issue 2, pp.97-106

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001326123

pISSN:

2587-0335

Non-Alcoholic Fatty Liver Disease

Non-Alcoholic Fatty Pancreas Disease

Insulin Resistance

Obesity

HOMA Index

Ultrasound Imagingİnsülin Direnci

Obezite

HOMA İndeksi

Ultrason Görüntüleme

Non alkolik Yağlı Pankreas Hastalığı

Non alkolik Yağlı Karaciğer Hastalığı

Sayı

Makale detayları

Yazarlar: Sevde Nur Emir | Servet Emir

Yayıncı: Zonguldak Bulent Ecevit University

Ana Başlıklar: Radyoloji ve Organ Görüntüleme

Dergi: Türkiye Diyabet ve Obezite Dergisi Vol.8 Issue 2, pp.97-106

Belge Tipi: Makale

Yayın Tarihi: 8/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001326123

pISSN: 2587-0335

Sayı

Yazarlar:

Sevde Nur Emir | Servet Emir

Yayıncı:

Zonguldak Bulent Ecevit University

Ana Başlıklar:

Radyoloji ve Organ Görüntüleme

Dergi:

Türkiye Diyabet ve Obezite Dergisi Vol.8 Issue 2, pp.97-106

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001326123

pISSN:

2587-0335