Preparation of PHBV Foams and Investigation of  Their Potential For Drug Release

Dilek ŞENDİL

Makale detayları

Preparation of PHBV Foams and Investigation of Their Potential For Drug Release

Yazarlar:

Dilek ŞENDİL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2000 Vol.30 Issue 1, pp.9-14

Belge Tipi:

Makale

Yayın Tarihi:

12/1999

Belge Dili:

Türkçe

Document ID (Org No.):

2000757722

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Polymeric foams seem to have  potential for use in many research areas such  as cell seeding and macromolecule or drug  loading. Three factors were studied to  evaluate the efficiency of foams as drug  carrier and releasing agents. Effect of  polymeric properties was examined by using  two types of polymers (PHBV 7 and PHBV  22) differing only in their valerate  (copolymer) content. The other factor  studied was the effect of loading extent on  release kinetics and rate. The results showed  an unexpected inverse proportionality  between drug loading and release rate. They,  however, were in accordance with foam  physical properties such as porosity, which  dominate the control of release from the  foam. When the concentration of the  polymer solution increased the density of the  resulting foam increased leading to a less  porous structure and to a slower release  rate. In all cases, complete drug release took  place within a very short time period most  probably due to the high water solubility and  low molecular weight of the drug molecule. It  is expected that it will be possible to achieve  a longer term release with larger bioactive  agents like enzymes, plasmids or antibodies.

 

Polymeric foams seem to have  potential for use in many research areas such  as cell seeding and macromolecule or drug  loading. Three factors were studied to  evaluate the efficiency of foams as drug  carrier and releasing agents. Effect of  polymeric properties was examined by using  two types of polymers (PHBV 7 and PHBV  22) differing only in their valerate  (copolymer) content. The other factor  studied was the effect of loading extent on  release kinetics and rate. The results showed  an unexpected inverse proportionality  between drug loading and release rate. They,  however, were in accordance with foam  physical properties such as porosity, which  dominate the control of release from the  foam. When the concentration of the  polymer solution increased the density of the  resulting foam increased leading to a less  porous structure and to a slower release  rate. In all cases, complete drug release took  place within a very short time period most  probably due to the high water solubility and  low molecular weight of the drug molecule. It  is expected that it will be possible to achieve  a longer term release with larger bioactive  agents like enzymes, plasmids or antibodies.

Makale detayları

Preparation of PHBV Foams and Investigation of Their Potential For Drug Release

Yazarlar:

Dilek ŞENDİL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2000 Vol.30 Issue 1, pp.9-14

Belge Tipi:

Makale

Yayın Tarihi:

12/1999

Belge Dili:

Türkçe

Document ID (Org No.):

2000757722

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Controlled Release

Poly(hydroxybutyrate-co-hydroxyvalerate)-PHBV

Polymer foams

Tetracycline.

Sayı

Makale detayları

Preparation of PHBV Foams and Investigation of Their Potential For Drug Release

Yazarlar: Dilek ŞENDİL

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2000 Vol.30 Issue 1, pp.9-14

Belge Tipi: Makale

Yayın Tarihi: 12/1999

Belge Dili: Türkçe

Document ID (Org No.): 2000757722

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Controlled Release

Poly(hydroxybutyrate-co-hydroxyvalerate)-PHBV

Polymer foams

Tetracycline.

Sayı

Yazarlar:

Dilek ŞENDİL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2000 Vol.30 Issue 1, pp.9-14

Belge Tipi:

Makale

Yayın Tarihi:

12/1999

Belge Dili:

Türkçe

Document ID (Org No.):

2000757722

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144