Investigation of in vitro anti-hyperpigmentation, antidiabetic, neuroprotective and antioxidant potential of Medicago murex WILLD. (Fabaceae)

Damla PAMUKCU; Volkan AYLANÇ; Bülent ESKİN; Gökhan ZENGİN; Mehmet DURSUN; Yavuz Selim ÇAKMAK

Makale detayları

Investigation of in vitro anti-hyperpigmentation, antidiabetic, neuroprotective and antioxidant potential of Medicago murex WILLD. (Fabaceae)

Yazarlar:

Damla PAMUKCU | Volkan AYLANÇ | Bülent ESKİN | Gökhan ZENGİN | Mehmet DURSUN | Yavuz Selim ÇAKMAK

Yayıncı:

Istanbul University

Ana Başlıklar:

Farmakoloji ve terapötik | Sağlık teşvikleri

Dergi:

İstanbul Journal of Pharmacy 2020 Vol.50 Issue 3, pp.289-293

Belge Tipi:

Makale

Yayın Tarihi:

12/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000512943

Sıklık:

Aylık

eISSN:

2587-2087

Özet:

 

Background and Aims: Most of the Medicago species are considered good quality forage crops due to their rich protein content. This study reports antioxidant properties, total phenolic and flavonoid content, enzyme (acetylcholinesterase (AChE), tyrosinase, α-amylase and α-glucosidase) inhibition activities of methanol (MeOH), ethyl acetate (EA) and, aqueous (AQ) extracts of Medicago murex (M. murex). Methods: The antioxidant activity of the different extracts of M. murex were evaluated using FRAP and CUPRAC assays. The contents of total phenolic and flavonoid were determined by the Folin–Ciocalteu and the Aluminium chloride (AlCl3) colorimetric methods. Also, the enzyme inhibition activities were shown spectrophotometrically for AChE, α-amylase, α-glucosidase and tyrosinase enzymes. Results: Total phenolic and flavonoid contents of different extracts were determined between 83.70-163.93 mg GAE/g extract and 24.48-26.05 μg QE/g extract, respectively. AQ extracts were the most active extracts in FRAP while being the best inhibitor of the AChE enzyme. On the other hand, EA extracts were the most active extracts in CUPRAC methods and the best inhibitors for other enzymes. Conclusion: Considering the findings, M. murex appears to be an important source of natural antioxidants and enzyme inhibitors, and it provides important baseline data for the food and pharmaceutical industries.

Makale detayları

Investigation of in vitro anti-hyperpigmentation, antidiabetic, neuroprotective and antioxidant potential of Medicago murex WILLD. (Fabaceae)

Yazarlar: Damla PAMUKCU | Volkan AYLANÇ | Bülent ESKİN | Gökhan ZENGİN | Mehmet DURSUN | Yavuz Selim ÇAKMAK

Yayıncı: Istanbul University

Ana Başlıklar: Farmakoloji ve terapötik | Sağlık teşvikleri

Dergi: İstanbul Journal of Pharmacy 2020 Vol.50 Issue 3, pp.289-293

Belge Tipi: Makale

Yayın Tarihi: 12/2020

Belge Dili: İngilizce

Document ID (Org No.): 2000512943

Sıklık: Aylık

eISSN: 2587-2087

Sayı

Yazarlar:

Damla PAMUKCU | Volkan AYLANÇ | Bülent ESKİN | Gökhan ZENGİN | Mehmet DURSUN | Yavuz Selim ÇAKMAK

Yayıncı:

Istanbul University

Ana Başlıklar:

Farmakoloji ve terapötik | Sağlık teşvikleri

Dergi:

İstanbul Journal of Pharmacy 2020 Vol.50 Issue 3, pp.289-293

Belge Tipi:

Makale

Yayın Tarihi:

12/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000512943

Sıklık:

Aylık

eISSN:

2587-2087