Tumour budding in preoperative biopsy specimens is a useful prognostic index for  identifying high-risk patients in early-stage  pN0  colon cancer

Mehmet ZENGİN; Aydın ÇİFCİ

doi:https://doi.org/10.3906/sag-1903-142

Makale detayları

Tumour budding in preoperative biopsy specimens is a useful prognostic index for identifying high-risk patients in early-stage pN0 colon cancer

Yazarlar:

Mehmet ZENGİN | Aydın ÇİFCİ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2020 Vol.50 Issue 2, pp.375-385

Belge Tipi:

Makale

Yayın Tarihi:

2/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000749593

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

DOI:

https://doi.org/10.3906/sag-1903-142

Özet:

 

Background/aim: Tumour budding  BD  is considered a valuable prognostic factor in colon cancer  CC , but its use in daily practice is  uncertain. We investigated the prognostic effect of BD using preoperative biopsy specimens in a fairly homogeneous population.  Materials and methods: Eighty-two  pN0  CC patients who underwent surgery after preoperative biopsy between 1997 and 2013 were  included in the study. Model A  using the deeply∈vasiveblocks&hot−spotarea&∈vasivemarg∈andmethod1usingthedeeply∈vasiveblocks&hot-spotarea&∈vasivemarg∈andmethod1usingthedeeply invasive blocks & hot-spot area & invasive margin  and method 1  using the 20×  objective & immunohistochemistry staining & quantitive counting'  were used as standard methods.  Results: High BD was significantly associated with poor prognostic factors  lymphatic invasion [P = 0.008], perineural invasion [P =  0.041], advanced pT [P = 0.015], invasive margin [P = 0.008], and margin involvement [P = 0.019] . Moreover, correlations between  different BD estimates  r = 0.613-0.696 , reproducibility of study  Kappa = 0.68-0.73 , and usefulness of cut-off value  area of under  ROC = 0.746 [0.663-0.829]  were well. In univariate analysis, 5-year survival was poor in patients with high BD  relaps-free survival  [RFS]: 71 %, P < 0.001; overall survival [OS]: 73 %, P = 0.004, local recurrence [LR]: 18 %, P = 0.032 . Multivariate analyses confirmed  that high BD is an independent worse survival parameter for RFS  Hazard ratio [HR]: 1.53 [1.14-2.80], P = 0.015 , OS  HR: 1.44  [1.17-2.75], P = 0.032, and LR  HR: 1.59 [1.05-2.76], P = 0.045 .  Conclusion: Our data show that BD provides valuable prognostic information for early-stage  pN0  CC in preoperative biopsy  specimens and that adding BD to current risk classification may contribute to better patient selection.

Makale detayları

Tumour budding in preoperative biopsy specimens is a useful prognostic index for identifying high-risk patients in early-stage pN0 colon cancer

Yazarlar: Mehmet ZENGİN | Aydın ÇİFCİ

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2020 Vol.50 Issue 2, pp.375-385

Belge Tipi: Makale

Yayın Tarihi: 2/2020

Belge Dili: İngilizce

Document ID (Org No.): 2000749593

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

DOI: https://doi.org/10.3906/sag-1903-142

Sayı

Yazarlar:

Mehmet ZENGİN | Aydın ÇİFCİ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2020 Vol.50 Issue 2, pp.375-385

Belge Tipi:

Makale

Yayın Tarihi:

2/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000749593

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

DOI:

https://doi.org/10.3906/sag-1903-142