A novel formulation strategy for skin occlusion: Semi-solid lipid nanoparticles

Gülin Amasya Çelikten

Makale detayları

A novel formulation strategy for skin occlusion: Semi-solid lipid nanoparticles

Yazarlar:

Gülin Amasya Çelikten

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 4, pp.388-397

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348078

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Lipid nanoparticles SLNs and NLCs have possessed many advantages as versatile and innovative carriers to achieve better quality and highly effective skin-care cosmeceuticals. While they protect the water content of the epidermis by increasing skin occlusion, maintain the smoothness and elasticity of the skin, enhance the efficacy of the active substance by penetrating into the deep layers of the skin. Semi-solid lipid nanoparticles, which are the latest generation of lipid nanoparticles containing high amount of lipids compared to SLNs and NLCs are promising systems as nano-cosmeceuticals due to their semi-solid consistency and colloidal particle size. In this study, semi-solid lipid nanoparticles in NLC form were obtained by using different vegetable oils that possess positive effects in the dermal application. Then, the main in vitro physicochemical characteristics of the formulations that affect skin hydration like size, surface charge, and occlusive properties were investigated. Overall results suggested that, while vegetable oil loaded semi-solid lipid nanoparticles were obtained, colloidal size and semi-solid consistency could be maintained. On the other hand, all formulations had acceptable firmness values for customer use despite the high lipid content of the system, and enhanced skin hydration with the help of both vegetable oils and lipid nanoparticles were achieved.

 Lipid nanoparticles SLNs and NLCs have possessed many advantages as versatile and innovative carriers to achieve better quality and highly effective skin-care cosmeceuticals. While they protect the water content of the epidermis by increasing skin occlusion, maintain the smoothness and elasticity of the skin, enhance the efficacy of the active substance by penetrating into the deep layers of the skin. Semi-solid lipid nanoparticles, which are the latest generation of lipid nanoparticles containing high amount of lipids compared to SLNs and NLCs are promising systems as nano-cosmeceuticals due to their semi-solid consistency and colloidal particle size. In this study, semi-solid lipid nanoparticles in NLC form were obtained by using different vegetable oils that possess positive effects in the dermal application. Then, the main in vitro physicochemical characteristics of the formulations that affect skin hydration like size, surface charge, and occlusive properties were investigated. Overall results suggested that, while vegetable oil loaded semi-solid lipid nanoparticles were obtained, colloidal size and semi-solid consistency could be maintained. On the other hand, all formulations had acceptable firmness values for customer use despite the high lipid content of the system, and enhanced skin hydration with the help of both vegetable oils and lipid nanoparticles were achieved.

 Lipid nanoparticles SLNs and NLCs have possessed many advantages as versatile and innovative carriers to achieve better quality and highly effective skin-care cosmeceuticals. While they protect the water content of the epidermis by increasing skin occlusion, maintain the smoothness and elasticity of the skin, enhance the efficacy of the active substance by penetrating into the deep layers of the skin. Semi-solid lipid nanoparticles, which are the latest generation of lipid nanoparticles containing high amount of lipids compared to SLNs and NLCs are promising systems as nano-cosmeceuticals due to their semi-solid consistency and colloidal particle size. In this study, semi-solid lipid nanoparticles in NLC form were obtained by using different vegetable oils that possess positive effects in the dermal application. Then, the main in vitro physicochemical characteristics of the formulations that affect skin hydration like size, surface charge, and occlusive properties were investigated. Overall results suggested that, while vegetable oil loaded semi-solid lipid nanoparticles were obtained, colloidal size and semi-solid consistency could be maintained. On the other hand, all formulations had acceptable firmness values for customer use despite the high lipid content of the system, and enhanced skin hydration with the help of both vegetable oils and lipid nanoparticles were achieved.

 Lipid nanoparticles SLNs and NLCs have possessed many advantages as versatile and innovative carriers to achieve better quality and highly effective skin-care cosmeceuticals. While they protect the water content of the epidermis by increasing skin occlusion, maintain the smoothness and elasticity of the skin, enhance the efficacy of the active substance by penetrating into the deep layers of the skin. Semi-solid lipid nanoparticles, which are the latest generation of lipid nanoparticles containing high amount of lipids compared to SLNs and NLCs are promising systems as nano-cosmeceuticals due to their semi-solid consistency and colloidal particle size. In this study, semi-solid lipid nanoparticles in NLC form were obtained by using different vegetable oils that possess positive effects in the dermal application. Then, the main in vitro physicochemical characteristics of the formulations that affect skin hydration like size, surface charge, and occlusive properties were investigated. Overall results suggested that, while vegetable oil loaded semi-solid lipid nanoparticles were obtained, colloidal size and semi-solid consistency could be maintained. On the other hand, all formulations had acceptable firmness values for customer use despite the high lipid content of the system, and enhanced skin hydration with the help of both vegetable oils and lipid nanoparticles were achieved.

Makale detayları

A novel formulation strategy for skin occlusion: Semi-solid lipid nanoparticles

Yazarlar:

Gülin Amasya Çelikten

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 4, pp.388-397

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348078

pISSN:

2630-6344

Semi-solid lipid nanoparticles

nano-cosmeceuticals

vegetable oil

skin occlusion.

Sayı

Makale detayları

A novel formulation strategy for skin occlusion: Semi-solid lipid nanoparticles

Yazarlar: Gülin Amasya Çelikten

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Delivery Technologies

Dergi: Journal of Research in Pharmacy Vol.25 Issue 4, pp.388-397

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001348078

pISSN: 2630-6344

Semi-solid lipid nanoparticles

nano-cosmeceuticals

vegetable oil

skin occlusion.

Sayı

Yazarlar:

Gülin Amasya Çelikten

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 4, pp.388-397

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348078

pISSN:

2630-6344