Quantitative Analysis of Dioxins and Dioxin-like Polychlorinated Biphenyls in İnci Kefali (Alburnus tarichi, Güldenstädt, 1814): Implications for Public Health Risk Assessment

Funda Aydin

Makale detayları

Quantitative Analysis of Dioxins and Dioxin-like Polychlorinated Biphenyls in İnci Kefali (Alburnus tarichi, Güldenstädt, 1814): Implications for Public Health Risk Assessment

Yazarlar:

Funda Aydin

Yayıncı:

Van Yuzuncu Yıl University

Ana Başlıklar:

Eczacılıkta Analitik Kimya

Dergi:

Van Sağlık Bilimleri Dergisi Vol.18 Issue 2, pp.131-138

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357510

pISSN:

2667-5072

Anahtar kelimeler:

Özet:

 Objective: Polychlorinated dibenzo-p-dioxin and furans PCDDFs and dioxin-like polychlorinated biphenyls dl-PCBs classified as persistent organic pollutants can enter the human food chain, especially through animal-based products like fish, and pose significant toxicological risks. The inci kefali Alburnus tarichi, Güldenstädt, 1814 an endemic species in Lake Van, is a widely consumed fish by the local population. Therefore, assessing the levels of these pollutants in inci kefali is of considerable importance for public health monitoring and risk assessment. Material and Method: In this study, a total of 30 inci kefali specimens were collected from ten different local fishers in Van Province. Sample preparation was performed in an accredited laboratory authorized by the Turkish Ministry of Agriculture, following EPA standard methods. PCDDFs, dl-PCBs, and indicator PCBs were analyzed by APGC-MSMS using isotope dilution with ¹³C-labeled internal standards. Results: The mean concentrations of PCDDFs, PCDDFs  dl-PCBs and indicator PCBs in the analyzed samples were found to be 0.056  0.008 pgWHO-TEQg wet weight, 0.220  0.019 pgWHO-TEQg wet weight and 0.135  0.010 ngg wet weight, respectively. The Tolerable Daily Intake TDI and Tolerable Weekly Intake TWI were calculated as 0.063 pgWHO-TEQkg body weightday and 0.440 pgWHO-TEQkg body weightweek, respectively. Conclusion: The results show that PCDDFs, PCDDFs  dl-PCBs, and indicator PCBs in inci kefali samples obtained from Lake Van are well below the legal limits set by the European Commission and the Turkish Food Codex. Furthermore, TDI and TWI values were also found to be below the limits set by the European Food Safety Authority. These findings show that inci kefali consumption does not currently pose a significant health risk to human health.

 Objective: Polychlorinated dibenzo-p-dioxin and furans PCDDFs and dioxin-like polychlorinated biphenyls dl-PCBs classified as persistent organic pollutants can enter the human food chain, especially through animal-based products like fish, and pose significant toxicological risks. The inci kefali Alburnus tarichi, Güldenstädt, 1814 an endemic species in Lake Van, is a widely consumed fish by the local population. Therefore, assessing the levels of these pollutants in inci kefali is of considerable importance for public health monitoring and risk assessment. Material and Method: In this study, a total of 30 inci kefali specimens were collected from ten different local fishers in Van Province. Sample preparation was performed in an accredited laboratory authorized by the Turkish Ministry of Agriculture, following EPA standard methods. PCDDFs, dl-PCBs, and indicator PCBs were analyzed by APGC-MSMS using isotope dilution with ¹³C-labeled internal standards. Results: The mean concentrations of PCDDFs, PCDDFs  dl-PCBs and indicator PCBs in the analyzed samples were found to be 0.056  0.008 pgWHO-TEQg wet weight, 0.220  0.019 pgWHO-TEQg wet weight and 0.135  0.010 ngg wet weight, respectively. The Tolerable Daily Intake TDI and Tolerable Weekly Intake TWI were calculated as 0.063 pgWHO-TEQkg body weightday and 0.440 pgWHO-TEQkg body weightweek, respectively. Conclusion: The results show that PCDDFs, PCDDFs  dl-PCBs, and indicator PCBs in inci kefali samples obtained from Lake Van are well below the legal limits set by the European Commission and the Turkish Food Codex. Furthermore, TDI and TWI values were also found to be below the limits set by the European Food Safety Authority. These findings show that inci kefali consumption does not currently pose a significant health risk to human health.

 Objective: Polychlorinated dibenzo-p-dioxin and furans PCDDFs and dioxin-like polychlorinated biphenyls dl-PCBs classified as persistent organic pollutants can enter the human food chain, especially through animal-based products like fish, and pose significant toxicological risks. The inci kefali Alburnus tarichi, Güldenstädt, 1814 an endemic species in Lake Van, is a widely consumed fish by the local population. Therefore, assessing the levels of these pollutants in inci kefali is of considerable importance for public health monitoring and risk assessment. Material and Method: In this study, a total of 30 inci kefali specimens were collected from ten different local fishers in Van Province. Sample preparation was performed in an accredited laboratory authorized by the Turkish Ministry of Agriculture, following EPA standard methods. PCDDFs, dl-PCBs, and indicator PCBs were analyzed by APGC-MSMS using isotope dilution with ¹³C-labeled internal standards. Results: The mean concentrations of PCDDFs, PCDDFs  dl-PCBs and indicator PCBs in the analyzed samples were found to be 0.056  0.008 pgWHO-TEQg wet weight, 0.220  0.019 pgWHO-TEQg wet weight and 0.135  0.010 ngg wet weight, respectively. The Tolerable Daily Intake TDI and Tolerable Weekly Intake TWI were calculated as 0.063 pgWHO-TEQkg body weightday and 0.440 pgWHO-TEQkg body weightweek, respectively. Conclusion: The results show that PCDDFs, PCDDFs  dl-PCBs, and indicator PCBs in inci kefali samples obtained from Lake Van are well below the legal limits set by the European Commission and the Turkish Food Codex. Furthermore, TDI and TWI values were also found to be below the limits set by the European Food Safety Authority. These findings show that inci kefali consumption does not currently pose a significant health risk to human health.

 In this study, a total of 30 İnci Kefali Alburnus tarichi Güldenstädt, 1814 specimens were collected from ten different local fishers in Van Province and analyzed for polychlorinated dibenzo-p-dioxins and furans PCDDFs, dioxin-like polychlorinated biphenyls dl-PCBs, and indicator PCBs ICES-6: PCB28, PCB52, PCB101, PCB138, PCB153, PCB180 using APGC-MSMS. The mean concentration of PCDDFs in the analyzed samples was determined as 0.056  0.008 pg WHO-TEQg wet weight, while the total PCDDF  dl-PCB concentration was 0.220  0.019 pg WHO-TEQg wet weight. The total concentration of indicator PCBs ICES-6 was measured as 0.135  0.01 ngg wet weight. When compared with the maximum permissible limits set by the European Commission Commission Regulation EU 2023915 and the Turkish Food Codex, the detected PCDDF  dl-PCB levels correspond to only 3.4 of the legal limit. Similarly, the ICES-6 concentration represents approximately 0.2 of the maximum residue limits defined in the relevant regulations. Additionally, the estimated TDI tolerable daily intake and TWI tolerable weekly intake values were calculated as 0.01486 pg TEQkgday and 0.104 pg TEQkgweek, respectively. These values are significantly below the limits recommended by EFSA 2018, which are 0.29 pg TEQkgday for TDI and 2 pg TEQkgweek for TWI. The findings indicate that the levels of PCDDF and dlPCBs, as persistent organic pollutants, in Alburnus tarichi pose no significant risk to public health and remain within safe limits.

Makale detayları

Quantitative Analysis of Dioxins and Dioxin-like Polychlorinated Biphenyls in İnci Kefali (Alburnus tarichi, Güldenstädt, 1814): Implications for Public Health Risk Assessment

Yazarlar:

Funda Aydin

Yayıncı:

Van Yuzuncu Yıl University

Ana Başlıklar:

Eczacılıkta Analitik Kimya

Dergi:

Van Sağlık Bilimleri Dergisi Vol.18 Issue 2, pp.131-138

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357510

pISSN:

2667-5072

Dioxins

Dioxin-like polychlorinated biphenyls

İnci kefali

APGC-MS/MS

Sayı

Makale detayları

Quantitative Analysis of Dioxins and Dioxin-like Polychlorinated Biphenyls in İnci Kefali (Alburnus tarichi, Güldenstädt, 1814): Implications for Public Health Risk Assessment

Yazarlar: Funda Aydin

Yayıncı: Van Yuzuncu Yıl University

Ana Başlıklar: Eczacılıkta Analitik Kimya

Dergi: Van Sağlık Bilimleri Dergisi Vol.18 Issue 2, pp.131-138

Belge Tipi: Makale

Yayın Tarihi: 8/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001357510

pISSN: 2667-5072

Dioxins

Dioxin-like polychlorinated biphenyls

İnci kefali

APGC-MS/MS

Sayı

Yazarlar:

Funda Aydin

Yayıncı:

Van Yuzuncu Yıl University

Ana Başlıklar:

Eczacılıkta Analitik Kimya

Dergi:

Van Sağlık Bilimleri Dergisi Vol.18 Issue 2, pp.131-138

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357510

pISSN:

2667-5072