Comparison of Diagnostic Efficacy of Lancet, Multi-Head Applicator, and Specific Immunoglobulin E in Allergy Testing

Serdar Al; Cigdem Aydogmus

Makale detayları

Comparison of Diagnostic Efficacy of Lancet, Multi-Head Applicator, and Specific Immunoglobulin E in Allergy Testing

Yazarlar:

Serdar Al | Cigdem Aydogmus

Yayıncı:

Istanbul University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

Çocuk Dergisi Vol.23 Issue 3, pp.255-263

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001303678

pISSN:

1308-8491

Anahtar kelimeler:

Özet:

 Objective: Allergic rhinitis and allergic asthma are common respiratory diseases in children. Skin prick tests SPT and allergen-specific immunoglobulin E SpIgE measurements play a crucial role in their diagnosis. In recent years, the use of rapid diagnostic kits has increased. This study aimed to investigate the diagnostic performance of multiheaded applicator and allergen SpIgE compared to the gold standard lanset. Materials and Methods: Skin prick tests were conducted on the same patients using both a multi-headed applicator and lancet with the same allergen solutions. Additionally, allergen SpIgE levels were measured for each patient. The diagnostic performances of multi-headed applicator and allergen SpIgE were statistically compared to those of lancet. Results: A total of 2100 SPTs were performed on 105 patients, from whom allergen SpIgE levels were also obtained. Allergen sensitivities were detected in order of prevalence as house dust mites, pollens, and molds. Sensitization rates were found to be 73.3 for multi-headed applicators, 82.9 for lanset, and 81 for SpIgE. The diagnostic sensitivity of the multiheaded applicator ranged from 0 to 52, and its correlations with lanset were weak. Conclusion: Rapid-result tests aimed at allergen sensitivity assessment showed limited effectiveness. The use of accurate and reliable diagnostic methods such as lancet-based SPT and SpIgE measurements is crucial. This study holds the distinction of being the first to evaluate different SPT methods using allergen solutions, providing important insights for accurate diagnosis and treatment of allergic diseases.

 Objective: Allergic rhinitis and allergic asthma are common respiratory diseases in children. Skin prick tests SPT and allergen-specific immunoglobulin E SpIgE measurements play a crucial role in their diagnosis. In recent years, the use of rapid diagnostic kits has increased. This study aimed to investigate the diagnostic performance of multiheaded applicator and allergen SpIgE compared to the gold standard lanset. Materials and Methods: Skin prick tests were conducted on the same patients using both a multi-headed applicator and lancet with the same allergen solutions. Additionally, allergen SpIgE levels were measured for each patient. The diagnostic performances of multi-headed applicator and allergen SpIgE were statistically compared to those of lancet. Results: A total of 2100 SPTs were performed on 105 patients, from whom allergen SpIgE levels were also obtained. Allergen sensitivities were detected in order of prevalence as house dust mites, pollens, and molds. Sensitization rates were found to be 73.3 for multi-headed applicators, 82.9 for lanset, and 81 for SpIgE. The diagnostic sensitivity of the multiheaded applicator ranged from 0 to 52, and its correlations with lanset were weak. Conclusion: Rapid-result tests aimed at allergen sensitivity assessment showed limited effectiveness. The use of accurate and reliable diagnostic methods such as lancet-based SPT and SpIgE measurements is crucial. This study holds the distinction of being the first to evaluate different SPT methods using allergen solutions, providing important insights for accurate diagnosis and treatment of allergic diseases.

 Objective: Allergic rhinitis and allergic asthma are common respiratory diseases in children. Skin prick tests SPT and allergen-specific immunoglobulin E SpIgE measurements play a crucial role in their diagnosis. In recent years, the use of rapid diagnostic kits has increased. This study aimed to investigate the diagnostic performance of multiheaded applicator and allergen SpIgE compared to the gold standard lanset. Materials and Methods: Skin prick tests were conducted on the same patients using both a multi-headed applicator and lancet with the same allergen solutions. Additionally, allergen SpIgE levels were measured for each patient. The diagnostic performances of multi-headed applicator and allergen SpIgE were statistically compared to those of lancet. Results: A total of 2100 SPTs were performed on 105 patients, from whom allergen SpIgE levels were also obtained. Allergen sensitivities were detected in order of prevalence as house dust mites, pollens, and molds. Sensitization rates were found to be 73.3 for multi-headed applicators, 82.9 for lanset, and 81 for SpIgE. The diagnostic sensitivity of the multiheaded applicator ranged from 0 to 52, and its correlations with lanset were weak. Conclusion: Rapid-result tests aimed at allergen sensitivity assessment showed limited effectiveness. The use of accurate and reliable diagnostic methods such as lancet-based SPT and SpIgE measurements is crucial. This study holds the distinction of being the first to evaluate different SPT methods using allergen solutions, providing important insights for accurate diagnosis and treatment of allergic diseases.

 Amaç: Alerjik rinit ve alerjik astım, çocuklarda sık görülen solunum hastalıklarıdır. Bu hastalıkların tanısında, deri prik testleri DPT ve alerjen spesifik immunglobulin E SpIgE ölçümleri önemli bir rol oynamaktadır. Son yıllarda hızlı tanı kitlerinin kullanımı artmıştır. Bu çalışmanın amacı çok başlı aplikatör ve alerjen SpIgElerin tanısal performanslarını altın standart kabul edilen lanset DPT göre etkinlikleri araştırıldı. Gereç ve Yöntem: Çok başlı aplikatör, lanset ile aynı alerjen solüsyonları kullanılarak aynı hastalara deri prik testleri yapıldı. Ayrıca, her hastadan alerjen SpIgE düzeyleri ölçüldü. Lanset ile yapılan DPTlere göre çok başlı aplikatör ve alerjen SpIgElerin tanısal performansları istatistiksel olarak incelendi. Bulgular: Toplamda alerjen SpIgEleri de alınan 105 hasta üzerinde 2100 DPT yapıldı. Hastalarda sıklık sırasına göre ev tozu akarı, polenler ve küf alerjen duyarlılığı saptandı. Çok başlı aplikatör ile yapılan DPT 73.3, lanset ile yapılan DPT 82.9 ve SpIgE ile yapılan test 81 oranında duyarlanma tespit edildi. Çok başlı aplikatörün tanısal duyarlılık değeri 0-52 arasında ve lanset ile korelasyonları zayıf bulundu. Sonuç: Hızlı sonuç alma amaçlı testler, alerjen duyarlılığını tespitte yeterince etkin olmamıştır. Lanset ile yapılan DPT ve SpIgE ölçümleri gibi doğru ve güvenilir tanı yöntemlerinin kullanılması önemlidir. Bu çalışma, alerjen duyarlılığı tespitinde alerjen solüsyonları da kullanılarak yapılan farklı DPT yöntemlerinin değerlendirildiği ilk çalışma olma özelliği taşımaktadır ve alerjik hastalıkların tanı ve tedavisinde doğru yönlendirmeler yapmak adına önemli bilgiler sunmaktadır.

Makale detayları

Comparison of Diagnostic Efficacy of Lancet, Multi-Head Applicator, and Specific Immunoglobulin E in Allergy Testing

Yazarlar:

Serdar Al | Cigdem Aydogmus

Yayıncı:

Istanbul University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

Çocuk Dergisi Vol.23 Issue 3, pp.255-263

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001303678

pISSN:

1308-8491

skin tests

sensitivity and specificity

equipment and supplies

children

allergyderi testleri

duyarlılık ve özgüllük

ekipman ve malzemeler

çocuklar

alerji

Sayı

Makale detayları

Yazarlar: Serdar Al | Cigdem Aydogmus

Yayıncı: Istanbul University

Ana Başlıklar: Klinik Tıp Bilimleri (Diğer)

Dergi: Çocuk Dergisi Vol.23 Issue 3, pp.255-263

Belge Tipi: Makale

Yayın Tarihi: 10/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001303678

pISSN: 1308-8491

Sayı

Yazarlar:

Serdar Al | Cigdem Aydogmus

Yayıncı:

Istanbul University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

Çocuk Dergisi Vol.23 Issue 3, pp.255-263

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001303678

pISSN:

1308-8491