Investıgatıon of the Relatıonshıp of  Two-Glass Test Wıth Prostate Bıopsy and the Presence and Grade of Asymptomatıc Prostate Inflammatıon In Men Wıth Serum Prostate-Specıfıc Antıgen  Level Between 2.5-10 Ng/Ml

Alpaslan Yüksel; Ali Tekin; Yusuf Şenoğlu; Dursun Baba; Mehmet Gamsızkan

Makale detayları

Investıgatıon of the Relatıonshıp of Two-Glass Test Wıth Prostate Bıopsy and the Presence and Grade of Asymptomatıc Prostate Inflammatıon In Men Wıth Serum Prostate-Specıfıc Antıgen Level Between 2.5-10 Ng/Ml

Yazarlar:

Alpaslan Yüksel | Ali Tekin | Yusuf Şenoğlu | Dursun Baba | Mehmet Gamsızkan

Yayıncı:

Duzce University

Ana Başlıklar:

Health Care Administration

Dergi:

Konuralp Medical Journal Vol.16 Issue 1, pp.54-59

Belge Tipi:

Makale

Yayın Tarihi:

3/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001313156

pISSN:

1309-3878

Anahtar kelimeler:

Özet:

 Objective: Prostate-specific antigen PSA is a marker used to detect prostate cancer. When high PSA values are detected, a prostate biopsy is performed considering the possibility of prostate cancer. PSA elevation is not specific to prostate cancer, but may also be caused by conditions such as benign prostatic hyperplasia BPH, urinary tract infection, and chronic prostatitis. Prostate cancer is not detected in approximately 66 of patients undergoing a biopsy, and patients are exposed to unnecessary biopsy and biopsy complications. Chronic prostatitis is detected in approximately 40 of these biopsies. The two-glass test is based on examining urine before and after rectal examination, which is used in diagnosing chronic prostatitis. In this study, we aimed to reveal the two-glass tests effectiveness in predicting the incidence of prostatitis and inflammation in patients with a PSA value of 2.5-10 ngml and who underwent prostate needle biopsy. Methods: Fifty-two male patients, aged between 50 and 78 years, with PSA values between 2.5 and 10 ngml, who applied to our clinic were included in the study. EPS-two-glass test and prostate biopsy were applied to all patients. EPS; is a sample obtained by removing the fluid from the urethra after a prostate massage; VB-3; shows the urine produced by taking about 10 ml of urine voided after massage. EPS and VB3 detect prostate infection. Under the microscope, 10 leukocytes were considered significant for prostate inflammation. According to the pathology results, the patients were divided into 3 groups; prostate cancer, BPH, and chronic prostatitis. The chronic prostatitis group was classified according to the histopathological calcification described by Nickel. Results: In this study, the ratio of chronic prostatitis was found to be 38. VB3 positivity was found to be statistically significant in the chronic prostatitis group compared to the other groups p  0.028. Although there was no statistically significant difference between the prevalence of inflammation and PSA elevation, PSA was found to be higher in the multifocal inflammation subgroup than in the focal inflammation patient group. Conclusion: The relationship between chronic prostatitis and PSA elevation remains a mystery. Although no statistical relationship was found between inflammation and PSA elevation in this study, the significant correlation between chronic prostatitis and VB3 positivity reinforces the possibility of this relationship. We believe that our results will form the basis for further studies to avoid unnecessary biopsies.

 Objective: Prostate-specific antigen PSA is a marker used to detect prostate cancer. When high PSA values are detected, a prostate biopsy is performed considering the possibility of prostate cancer. PSA elevation is not specific to prostate cancer, but may also be caused by conditions such as benign prostatic hyperplasia BPH, urinary tract infection, and chronic prostatitis. Prostate cancer is not detected in approximately 66 of patients undergoing a biopsy, and patients are exposed to unnecessary biopsy and biopsy complications. Chronic prostatitis is detected in approximately 40 of these biopsies. The two-glass test is based on examining urine before and after rectal examination, which is used in diagnosing chronic prostatitis. In this study, we aimed to reveal the two-glass tests effectiveness in predicting the incidence of prostatitis and inflammation in patients with a PSA value of 2.5-10 ngml and who underwent prostate needle biopsy. Methods: Fifty-two male patients, aged between 50 and 78 years, with PSA values between 2.5 and 10 ngml, who applied to our clinic were included in the study. EPS-two-glass test and prostate biopsy were applied to all patients. EPS; is a sample obtained by removing the fluid from the urethra after a prostate massage; VB-3; shows the urine produced by taking about 10 ml of urine voided after massage. EPS and VB3 detect prostate infection. Under the microscope, 10 leukocytes were considered significant for prostate inflammation. According to the pathology results, the patients were divided into 3 groups; prostate cancer, BPH, and chronic prostatitis. The chronic prostatitis group was classified according to the histopathological calcification described by Nickel. Results: In this study, the ratio of chronic prostatitis was found to be 38. VB3 positivity was found to be statistically significant in the chronic prostatitis group compared to the other groups p  0.028. Although there was no statistically significant difference between the prevalence of inflammation and PSA elevation, PSA was found to be higher in the multifocal inflammation subgroup than in the focal inflammation patient group. Conclusion: The relationship between chronic prostatitis and PSA elevation remains a mystery. Although no statistical relationship was found between inflammation and PSA elevation in this study, the significant correlation between chronic prostatitis and VB3 positivity reinforces the possibility of this relationship. We believe that our results will form the basis for further studies to avoid unnecessary biopsies.

 Objective: Prostate-specific antigen PSA is a marker used to detect prostate cancer. When high PSA values are detected, a prostate biopsy is performed considering the possibility of prostate cancer. PSA elevation is not specific to prostate cancer, but may also be caused by conditions such as benign prostatic hyperplasia BPH, urinary tract infection, and chronic prostatitis. Prostate cancer is not detected in approximately 66 of patients undergoing a biopsy, and patients are exposed to unnecessary biopsy and biopsy complications. Chronic prostatitis is detected in approximately 40 of these biopsies. The two-glass test is based on examining urine before and after rectal examination, which is used in diagnosing chronic prostatitis. In this study, we aimed to reveal the two-glass tests effectiveness in predicting the incidence of prostatitis and inflammation in patients with a PSA value of 2.5-10 ngml and who underwent prostate needle biopsy. Methods: Fifty-two male patients, aged between 50 and 78 years, with PSA values between 2.5 and 10 ngml, who applied to our clinic were included in the study. EPS-two-glass test and prostate biopsy were applied to all patients. EPS; is a sample obtained by removing the fluid from the urethra after a prostate massage; VB-3; shows the urine produced by taking about 10 ml of urine voided after massage. EPS and VB3 detect prostate infection. Under the microscope, 10 leukocytes were considered significant for prostate inflammation. According to the pathology results, the patients were divided into 3 groups; prostate cancer, BPH, and chronic prostatitis. The chronic prostatitis group was classified according to the histopathological calcification described by Nickel. Results: In this study, the ratio of chronic prostatitis was found to be 38. VB3 positivity was found to be statistically significant in the chronic prostatitis group compared to the other groups p  0.028. Although there was no statistically significant difference between the prevalence of inflammation and PSA elevation, PSA was found to be higher in the multifocal inflammation subgroup than in the focal inflammation patient group. Conclusion: The relationship between chronic prostatitis and PSA elevation remains a mystery. Although no statistical relationship was found between inflammation and PSA elevation in this study, the significant correlation between chronic prostatitis and VB3 positivity reinforces the possibility of this relationship. We believe that our results will form the basis for further studies to avoid unnecessary biopsies.

 Amaç: Prostat-spesifik antijen PSA prostat kanserini belirlemede kullanılan bir belirteçtir. Yüksek PSA değerleri saptandığında prostat kanseri olasılığı düşünülerek prostat biyopsisi uygulanmaktadır. PSA yüksekliği, prostat kanserine spesifik olmayıp benign prostat hiperplazisi BPH , idrar yolu enfeksiyonu ve kronik prostatit gibi durumlardan da kaynaklanabilmektedir. .Biyopsi yapılan hastaların yaklaşık 66sında prostat kanseri saptanmayıp, hastalar gereksiz biyopsiye ve biyopsi komplikasyonlarına maruz kalmaktadır. Bu biyopsilerin yaklaşık  40ında kronik prostatit saptanmaktadır.İki kadeh testi kronik prostatit tanısında kullanılan rektal tuşe öncesi ve sonrası idrarın incelenmesine dayanır. Biz bu çalışmamızda PSA değeri 2,5-10 ngml arasında olan ve prostat iğne biyopsisi uygulanmış hastalarda prostatit insidansını ve infalamasyonu öngörmesi açısından iki kadeh testinin etkinliğini ortaya çıkarmayı amaçladık. Materyal ve Yöntem: Kliniğimize başvuran yaşları 50 ile 78, PSA değerleri 2.5-10 ngml arasında olan 52 erkek hasta çalışmaya alındı. Tüm hastalara EPS iki kadeh testi incelemesi ve prostat biyopsisi uygulandı. EPS; prostat masajı sonrası üretraya gelen sıvının alınması ile elde edilen örneği; VB-3; masajdan sonra işenen yaklaşık 10 mllik idrarın alınması İle Sağlanan İdrarı Gösterir. EPS Ve VB3 Prostat İnfeksiyonunu Saptar. Mikroskop Altında 10 lökosit prostat inflamasyonu için anlamlı kabül edildi. Hastalar çıkan patoloji sonucuna göre Prostat kanseri, BPH ve Kronik prostatit şeklinde 3 gruba ayrıldı. Kronik prostatitli grup Nickelin tanımladığı histopatolojik kalsifikasyonuna göre sınıflandırıldı. Bulgular: Bu çalışmada kronik prostatit prevelansı 38 olarak bulundu. VB3 pozitifliği diğer gruplara göre kronik prostatit grubunda istatistiksel olarak anlamlı bulundu  p  0,028. İnflamasyon yaygınlığı ile PSA yüksekliği arasında istatistiksel olarak anlamlılık saptanmasa da PSA multifokal inflamasyonlu alt grupta fokal inflamasyonlu hasta grubuna göre daha yüksek bulunmuştur. Sonuç: Kronik prostatit ile PSA yüksekliği arasındaki ilişki halen gizemini korumaktadır. Bu çalışmada inflamasyon ile PSA yüksekliği arasında istatistiksel bir ilişki saptanmasa da kronik prostatit ile VB3 pozitifliği arasındaki anlamlı korelasyon bu ilişkinin olabileceği hususunu güçlendirmektedir. Bizim sonuçlarımızın gereksiz biyopsiden kaçınmak için yapılacak daha ileri çalışmalar için temel verileri oluşturacağına inanıyoruz.

Makale detayları

Investıgatıon of the Relatıonshıp of Two-Glass Test Wıth Prostate Bıopsy and the Presence and Grade of Asymptomatıc Prostate Inflammatıon In Men Wıth Serum Prostate-Specıfıc Antıgen Level Between 2.5-10 Ng/Ml

Yazarlar:

Alpaslan Yüksel | Ali Tekin | Yusuf Şenoğlu | Dursun Baba | Mehmet Gamsızkan

Yayıncı:

Duzce University

Ana Başlıklar:

Health Care Administration

Dergi:

Konuralp Medical Journal Vol.16 Issue 1, pp.54-59

Belge Tipi:

Makale

Yayın Tarihi:

3/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001313156

pISSN:

1309-3878

PSA elevation

Prostate cancer

Chronic prostatitis

Two glass testPSA yüksekliği

Prostat kanseri

Kronik prostatit

İki kadeh testi

Sayı

Makale detayları

Yazarlar: Alpaslan Yüksel | Ali Tekin | Yusuf Şenoğlu | Dursun Baba | Mehmet Gamsızkan

Yayıncı: Duzce University

Ana Başlıklar: Health Care Administration

Dergi: Konuralp Medical Journal Vol.16 Issue 1, pp.54-59

Belge Tipi: Makale

Yayın Tarihi: 3/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001313156

pISSN: 1309-3878

Sayı

Yazarlar:

Alpaslan Yüksel | Ali Tekin | Yusuf Şenoğlu | Dursun Baba | Mehmet Gamsızkan

Yayıncı:

Duzce University

Ana Başlıklar:

Health Care Administration

Dergi:

Konuralp Medical Journal Vol.16 Issue 1, pp.54-59

Belge Tipi:

Makale

Yayın Tarihi:

3/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001313156

pISSN:

1309-3878